Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0055 | 0.0716 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0061 | 0.0883 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0189 | 0.4605 | 0.4367 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0061 | 0.0883 | 0.0429 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0061 | 0.0883 | 0.0429 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0061 | 0.0883 | 0.0429 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.0716 | 0.0231 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0083 | 0.1521 | 0.2071 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0061 | 0.0883 | 0.0429 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0189 | 0.4605 | 0.4323 |
Echinococcus granulosus | aminopeptidase N | 0.0164 | 0.3882 | 0.3561 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0083 | 0.1521 | 0.2933 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0116 | 0.2473 | 0.2079 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0375 | 1 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0164 | 0.3882 | 0.4656 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0099 | 0.0019 |
Brugia malayi | initiation factor 2-associated protein. | 0.0189 | 0.4605 | 0.5543 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Onchocerca volvulus | 0.0164 | 0.3882 | 0.8429 | |
Toxoplasma gondii | aminopeptidase N protein | 0.0362 | 0.9621 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1117 | 0.1028 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.0716 | 0.0623 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0061 | 0.0883 | 0.0883 |
Schistosoma mansoni | immunophilin | 0.0047 | 0.0497 | 0.0402 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.0716 | 0.0623 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0055 | 0.0716 | 0.0716 |
Onchocerca volvulus | 0.0061 | 0.0883 | 0.1918 | |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.055 | 0.055 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1117 | 0.1267 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0083 | 0.1521 | 0.4584 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0061 | 0.0883 | 0.0406 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0055 | 0.0716 | 0.0776 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0061 | 0.0883 | 0.0429 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0083 | 0.1521 | 0.2933 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0189 | 0.4605 | 0.4605 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0241 | 0.0194 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0061 | 0.0883 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2123 | 0.2123 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0068 | 0.1109 | 0.1011 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0068 | 0.1109 | 0.1011 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0362 | 0.9621 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0061 | 0.0883 | 0.0187 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0055 | 0.0716 | 0.0623 |
Trichomonas vaginalis | immunophilin, putative | 0.0055 | 0.0716 | 0.1088 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0083 | 0.1521 | 0.1437 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0068 | 0.1109 | 0.1011 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0055 | 0.0716 | 0.1088 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0116 | 0.2473 | 0.5 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0083 | 0.1521 | 0.1437 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0189 | 0.4605 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1117 | 0.2006 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1117 | 0.2006 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0061 | 0.0883 | 0.0406 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0116 | 0.2473 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0055 | 0.0716 | 0.1088 |
Entamoeba histolytica | aminopeptidase, putative | 0.0083 | 0.1521 | 0.2071 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.0716 | 0.0231 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0375 | 1 | 1 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0116 | 0.2473 | 1 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0055 | 0.0716 | 0.0231 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0083 | 0.1521 | 0.2071 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0116 | 0.2473 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 0.4367 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0061 | 0.0883 | 0.0429 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0061 | 0.0883 | 0.095 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0326 | 0.0194 |
Onchocerca volvulus | 0.0083 | 0.1521 | 0.3304 | |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0068 | 0.1109 | 0.1011 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Brugia malayi | hypothetical protein | 0.0314 | 0.8241 | 1 |
Giardia lamblia | Methionine aminopeptidase | 0.0189 | 0.4605 | 1 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0883 | 0.098 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0083 | 0.1521 | 0.2071 |
Echinococcus multilocularis | aminopeptidase N | 0.0164 | 0.3882 | 0.3561 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1485 | 0.1485 |
Loa Loa (eye worm) | aminopeptidase N | 0.0083 | 0.1521 | 0.1521 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0116 | 0.2473 | 0.2079 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0033 | 0.0083 | 0.0083 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0189 | 0.4605 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.0241 |
Brugia malayi | Peptidase family M1 containing protein | 0.0083 | 0.1521 | 0.1763 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0083 | 0.0083 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0189 | 0.4605 | 0.4551 |
Brugia malayi | hypothetical protein | 0.0083 | 0.1521 | 0.1763 |
Brugia malayi | TATA binding protein associated factor | 0.0061 | 0.0883 | 0.098 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1117 | 0.1028 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 0.2983 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0055 | 0.0716 | 0.0776 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0362 | 0.9621 | 1 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0116 | 0.2473 | 0.5 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0068 | 0.1109 | 0.0442 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0116 | 0.2473 | 0.1973 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0189 | 0.4605 | 0.4323 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0326 | 0.0708 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0061 | 0.0883 | 0.0792 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.055 | 0.055 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0083 | 0.1521 | 0.2071 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0061 | 0.0883 | 0.1471 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0099 | 0.0099 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0083 | 0.1521 | 0.2071 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0061 | 0.0883 | 0.0429 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0061 | 0.0883 | 0.0792 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Trypanosoma brucei | aminopeptidase, putative | 0.0061 | 0.0883 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0497 | 0.0497 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0142 | 0.3243 | 0.3243 |
Echinococcus multilocularis | fk506 binding protein | 0.0055 | 0.0716 | 0.0231 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0083 | 0.1521 | 0.1078 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0241 | 0.0524 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0055 | 0.0716 | 0.1088 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.055 | 0.0572 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1117 | 0.1117 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.055 | 0.0572 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0326 | 0.0194 |
Loa Loa (eye worm) | FKBP5 protein | 0.0055 | 0.0716 | 0.0716 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0375 | 1 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0362 | 0.9621 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0362 | 0.9621 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKb (functional) | = 5.45 | Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) | ChEMBL. | 12672251 |
pKb (functional) | = 6 | Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 6.82 | Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 5.45 | Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) | ChEMBL. | 12672251 |
pKb (functional) | = 6 | Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 6.82 | Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) | ChEMBL. | 12672251 |
Selectivity (functional) | = 0.2 | Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1A receptor in rat | ChEMBL. | 12672251 |
Selectivity (functional) | = 5 | Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1B receptor in rat | ChEMBL. | 12672251 |
Selectivity (functional) | = 23 | Selectivity given as ratio of pKb value against alpha1A receptor to pKb value against alpha1B receptor in rat | ChEMBL. | 12672251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.