Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Peptidase family M1 containing protein | 0.0061 | 0.0883 | 0.098 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0055 | 0.0716 | 0.0623 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0116 | 0.2473 | 0.5 |
Onchocerca volvulus | 0.0083 | 0.1521 | 0.3304 | |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0083 | 0.1521 | 0.1078 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0083 | 0.1521 | 0.2071 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0241 | 0.0524 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0061 | 0.0883 | 0.0429 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.055 | 0.0572 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.0716 | 0.0623 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0326 | 0.0194 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0189 | 0.4605 | 0.4605 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0142 | 0.3243 | 0.3243 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0099 | 0.0019 |
Onchocerca volvulus | 0.0164 | 0.3882 | 0.8429 | |
Entamoeba histolytica | aminopeptidase, putative | 0.0083 | 0.1521 | 0.2071 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 1 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.0716 | 0.0231 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0061 | 0.0883 | 0.1471 |
Brugia malayi | hypothetical protein | 0.0083 | 0.1521 | 0.1763 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0068 | 0.1109 | 0.1011 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.0716 | 0.0231 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0061 | 0.0883 | 0.0406 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0083 | 0.1521 | 0.2071 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0083 | 0.1521 | 0.4584 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0326 | 0.0194 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1117 | 0.1117 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1117 | 0.1028 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0083 | 0.1521 | 0.2933 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0061 | 0.0883 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2123 | 0.2123 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0061 | 0.0883 | 0.0792 |
Giardia lamblia | Methionine aminopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0083 | 0.1521 | 0.2071 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0116 | 0.2473 | 0.2079 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0497 | 0.0497 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0375 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.055 | 0.0572 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trypanosoma brucei | aminopeptidase, putative | 0.0061 | 0.0883 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0061 | 0.0883 | 0.0429 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0061 | 0.0883 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0055 | 0.0716 | 0.0716 |
Onchocerca volvulus | 0.0061 | 0.0883 | 0.1918 | |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0061 | 0.0883 | 0.0429 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0116 | 0.2473 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0362 | 0.9621 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0055 | 0.0716 | 0.1088 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.055 | 0.055 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0055 | 0.0716 | 0.0776 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0061 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.0241 |
Echinococcus granulosus | aminopeptidase N | 0.0164 | 0.3882 | 0.3561 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0061 | 0.0883 | 0.0429 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0241 | 0.0194 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0033 | 0.0083 | 0.0083 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0083 | 0.1521 | 0.2933 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0883 | 0.098 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0068 | 0.1109 | 0.0442 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0068 | 0.1109 | 0.1011 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Loa Loa (eye worm) | aminopeptidase N | 0.0083 | 0.1521 | 0.1521 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0055 | 0.0716 | 0.0776 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0189 | 0.4605 | 0.4367 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0189 | 0.4605 | 1 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0116 | 0.2473 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Brugia malayi | initiation factor 2-associated protein. | 0.0189 | 0.4605 | 0.5543 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0061 | 0.0883 | 0.0187 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0116 | 0.2473 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.055 | 0.055 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1117 | 0.2006 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0116 | 0.2473 | 0.2079 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0083 | 0.1521 | 0.1437 |
Trichomonas vaginalis | immunophilin, putative | 0.0055 | 0.0716 | 0.1088 |
Toxoplasma gondii | aminopeptidase N protein | 0.0362 | 0.9621 | 1 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0083 | 0.1521 | 0.1437 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0116 | 0.2473 | 0.5 |
Loa Loa (eye worm) | FKBP5 protein | 0.0055 | 0.0716 | 0.0716 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0055 | 0.0716 | 0.1088 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0189 | 0.4605 | 1 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 0.2983 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0055 | 0.0716 | 0.1088 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0083 | 0.1521 | 0.2071 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Brugia malayi | Peptidase family M1 containing protein | 0.0164 | 0.3882 | 0.4656 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0068 | 0.1109 | 0.1011 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0068 | 0.1109 | 0.1011 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0189 | 0.4605 | 0.4323 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0083 | 0.0083 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus multilocularis | fk506 binding protein | 0.0055 | 0.0716 | 0.0231 |
Brugia malayi | Peptidase family M1 containing protein | 0.0083 | 0.1521 | 0.1763 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0099 | 0.0099 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0055 | 0.0716 | 0.0231 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0189 | 0.4605 | 0.4551 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0116 | 0.2473 | 0.1973 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.0716 | 0.0623 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0326 | 0.0708 |
Echinococcus multilocularis | aminopeptidase N | 0.0164 | 0.3882 | 0.3561 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0083 | 0.1521 | 0.2071 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0061 | 0.0883 | 0.0792 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1117 | 0.1267 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0061 | 0.0883 | 0.0429 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 0.4367 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0055 | 0.0716 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0047 | 0.0497 | 0.0402 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0061 | 0.0883 | 0.0429 |
Brugia malayi | TATA binding protein associated factor | 0.0061 | 0.0883 | 0.098 |
Brugia malayi | hypothetical protein | 0.0314 | 0.8241 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0362 | 0.9621 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0362 | 0.9621 | 1 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0362 | 0.9621 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1117 | 0.1028 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0061 | 0.0883 | 0.0429 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0189 | 0.4605 | 0.4323 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1485 | 0.1485 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1117 | 0.2006 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0061 | 0.0883 | 0.0406 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKb (functional) | = 5.45 | Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) | ChEMBL. | 12672251 |
pKb (functional) | = 6 | Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 6.82 | Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 5.45 | Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) | ChEMBL. | 12672251 |
pKb (functional) | = 6 | Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 6.82 | Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) | ChEMBL. | 12672251 |
Selectivity (functional) | = 0.2 | Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1A receptor in rat | ChEMBL. | 12672251 |
Selectivity (functional) | = 5 | Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1B receptor in rat | ChEMBL. | 12672251 |
Selectivity (functional) | = 23 | Selectivity given as ratio of pKb value against alpha1A receptor to pKb value against alpha1B receptor in rat | ChEMBL. | 12672251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.