Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0033 | 0.2591 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2591 | 0.2591 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0033 | 0.2591 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.002 | 0.0038 | 0.5 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.002 | 0.0038 | 0.5 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0033 | 0.2591 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1585 | 0.1585 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.002 | 0.0038 | 0.5 |
Leishmania major | endonuclease G, putative | 0.002 | 0.0038 | 0.5 |
Onchocerca volvulus | 0.0071 | 1 | 1 | |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0071 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0028 | 0.1585 | 0.6061 |
Trypanosoma cruzi | endonuclease G, putative | 0.002 | 0.0038 | 0.5 |
Echinococcus granulosus | ectonucleotide | 0.0028 | 0.1585 | 0.6061 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2591 | 0.2591 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0033 | 0.2591 | 0.2563 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.002 | 0.0038 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.002 | 0.0038 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2591 | 0.2591 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.002 | 0.0038 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Echinococcus multilocularis | ectonucleotide | 0.0028 | 0.1585 | 0.6061 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0033 | 0.2591 | 0.2563 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0028 | 0.1585 | 0.6061 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.002 | 0.0038 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0033 | 0.2591 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.002 | 0.0038 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | > 10 p.p.m. | In vitro flea activity using a membrane feeding assay wherein adult fleas ingest drug-treated bovine blood | ChEMBL. | 12467636 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.