Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxysteroid (11-beta) dehydrogenase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable oxidoreductase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Mycobacterium ulcerans | short chain dehydrogenase | Get druggable targets OG5_132866 | All targets in OG5_132866 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxysteroid (11-beta) dehydrogenase 1 | 292 aa | 250 aa | 24.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.324 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.1577 | 0.4611 | 0.4611 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1541 | 0.4495 | 1 |
Onchocerca volvulus | 0.324 | 1 | 1 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.324 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.324 | 1 | 1 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0695 | 0.1751 | 0.1751 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.324 | 1 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0154 | 0 | 0.5 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0385 | 0.0748 | 0.0748 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0154 | 0 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.324 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.324 | 1 | 1 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0385 | 0.0748 | 0.0748 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.324 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1577 | 0.4611 | 0.4611 |
Brugia malayi | hypothetical protein | 0.1541 | 0.4495 | 0.4495 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0385 | 0.0748 | 0.0748 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1577 | 0.4611 | 0.4611 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1541 | 0.4495 | 0.4495 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.324 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1541 | 0.4495 | 0.4495 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.324 | 1 | 1 |
Giardia lamblia | CDC8 | 0.0154 | 0 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.324 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.324 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0695 | 0.1751 | 0.1751 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0154 | 0 | 0.5 |
Chlamydia trachomatis | thymidylate kinase | 0.0154 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.324 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.324 | 1 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0385 | 0.0748 | 0.0748 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.