Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0189 | 0.4605 | 0.4367 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.0055 | 0.0716 | 0.0776 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Loa Loa (eye worm) | aminopeptidase N | 0.0083 | 0.1521 | 0.1521 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0068 | 0.1109 | 0.1011 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0116 | 0.2473 | 1 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0189 | 0.4605 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1117 | 0.2006 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.055 | 0.055 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0116 | 0.2473 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0061 | 0.0883 | 0.0187 |
Brugia malayi | initiation factor 2-associated protein. | 0.0189 | 0.4605 | 0.5543 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Toxoplasma gondii | aminopeptidase N protein | 0.0362 | 0.9621 | 1 |
Trichomonas vaginalis | immunophilin, putative | 0.0055 | 0.0716 | 0.1088 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0083 | 0.1521 | 0.1437 |
Echinococcus multilocularis | leucine aminopeptidase protein | 0.0116 | 0.2473 | 0.2079 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0116 | 0.2473 | 0.5 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0083 | 0.1521 | 0.1437 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0055 | 0.0716 | 0.1088 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0083 | 0.1521 | 0.2071 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 0.2983 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0189 | 0.4605 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0055 | 0.0716 | 0.1088 |
Loa Loa (eye worm) | FKBP5 protein | 0.0055 | 0.0716 | 0.0716 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0083 | 0.0083 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0068 | 0.1109 | 0.1011 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0189 | 0.4605 | 0.4323 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0068 | 0.1109 | 0.1011 |
Brugia malayi | Peptidase family M1 containing protein | 0.0164 | 0.3882 | 0.4656 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0099 | 0.0099 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Brugia malayi | Peptidase family M1 containing protein | 0.0083 | 0.1521 | 0.1763 |
Echinococcus multilocularis | fk506 binding protein | 0.0055 | 0.0716 | 0.0231 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.0716 | 0.0623 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0116 | 0.2473 | 0.1973 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.0055 | 0.0716 | 0.0231 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0189 | 0.4605 | 0.4551 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0083 | 0.1521 | 0.2071 |
Echinococcus multilocularis | aminopeptidase N | 0.0164 | 0.3882 | 0.3561 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.0326 | 0.0708 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.1117 | 0.1267 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0061 | 0.0883 | 0.0792 |
Brugia malayi | TATA binding protein associated factor | 0.0061 | 0.0883 | 0.098 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0061 | 0.0883 | 0.0429 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.0055 | 0.0716 | 0.5 |
Schistosoma mansoni | immunophilin | 0.0047 | 0.0497 | 0.0402 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0061 | 0.0883 | 0.0429 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 0.4367 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0362 | 0.9621 | 1 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0362 | 0.9621 | 1 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0362 | 0.9621 | 1 |
Brugia malayi | hypothetical protein | 0.0314 | 0.8241 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0061 | 0.0883 | 0.0429 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1117 | 0.1028 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0061 | 0.0883 | 0.0406 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.1117 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1485 | 0.1485 |
Echinococcus granulosus | methionyl aminopeptidase 2 | 0.0189 | 0.4605 | 0.4323 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0083 | 0.1521 | 0.1078 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0116 | 0.2473 | 0.5 |
Onchocerca volvulus | 0.0083 | 0.1521 | 0.3304 | |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0189 | 0.4605 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0061 | 0.0883 | 0.098 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.0055 | 0.0716 | 0.0623 |
Loa Loa (eye worm) | initiation factor 2-associated protein | 0.0189 | 0.4605 | 0.4605 |
Schistosoma mansoni | immunophilin | 0.0055 | 0.0716 | 0.0623 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0326 | 0.0194 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0061 | 0.0883 | 0.0429 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.055 | 0.0572 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0039 | 0.0241 | 0.0524 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0083 | 0.1521 | 0.2071 |
Entamoeba histolytica | aminopeptidase, putative | 0.0083 | 0.1521 | 0.2071 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0099 | 0.0019 |
Onchocerca volvulus | 0.0164 | 0.3882 | 0.8429 | |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0142 | 0.3243 | 0.3243 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.0716 | 0.0231 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 1 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0068 | 0.1109 | 0.1011 |
Brugia malayi | hypothetical protein | 0.0083 | 0.1521 | 0.1763 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0061 | 0.0883 | 0.1471 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0375 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0083 | 0.1521 | 0.2071 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0083 | 0.1521 | 0.4584 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.0055 | 0.0716 | 0.0231 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0061 | 0.0883 | 0.0406 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.1117 | 0.1028 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0189 | 0.4605 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.0326 | 0.0194 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.1117 | 0.1117 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0061 | 0.0883 | 0.0792 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.2123 | 0.2123 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0061 | 0.0883 | 0.0187 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0083 | 0.1521 | 0.2933 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0083 | 0.1521 | 0.2071 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Giardia lamblia | Methionine aminopeptidase | 0.0189 | 0.4605 | 1 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.055 | 0.0572 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.1117 | 0.0652 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0375 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0497 | 0.0497 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Echinococcus granulosus | leucine aminopeptidase protein | 0.0116 | 0.2473 | 0.2079 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trypanosoma brucei | aminopeptidase, putative | 0.0061 | 0.0883 | 0.0429 |
Onchocerca volvulus | 0.0033 | 0.0083 | 0.0181 | |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0061 | 0.0883 | 0.0429 |
Onchocerca volvulus | 0.0061 | 0.0883 | 0.1918 | |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.0055 | 0.0716 | 0.0716 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0061 | 0.0883 | 0.095 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0061 | 0.0883 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0883 | 0.0883 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0116 | 0.2473 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.055 | 0.055 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.0055 | 0.0716 | 0.1088 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0362 | 0.9621 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0083 | 0.1521 | 0.2071 |
Brugia malayi | chromobox protein homolog 3 | 0.0039 | 0.0241 | 0.0194 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0061 | 0.0883 | 0.0429 |
Echinococcus granulosus | aminopeptidase N | 0.0164 | 0.3882 | 0.3561 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0241 | 0.0241 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.0055 | 0.0716 | 0.0776 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0061 | 0.0883 | 0.0883 |
Brugia malayi | hypothetical protein | 0.0061 | 0.0883 | 0.098 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0068 | 0.1109 | 0.0442 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0083 | 0.1521 | 0.1078 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0083 | 0.1521 | 0.2933 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0033 | 0.0083 | 0.0083 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKb (functional) | = 5.13 | Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 5.36 | Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 5.77 | Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) | ChEMBL. | 12672251 |
pKb (functional) | = 5.13 | Inhibition of (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 5.36 | Inhibition of (-)-noradrenaline-induced contraction of rat prostatic vas deferens (alpha1A receptor) | ChEMBL. | 12672251 |
pKb (functional) | = 5.77 | Inhibition of (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor ) | ChEMBL. | 12672251 |
Selectivity (functional) | = 0.2 | Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1B receptor in rat | ChEMBL. | 12672251 |
Selectivity (functional) | = 0.4 | Selectivity given as ratio of pKb value against alpha1A receptor to pKb value against alpha1B receptor in rat | ChEMBL. | 12672251 |
Selectivity (functional) | = 0.6 | Selectivity given as ratio of pKb value against alpha1D receptor to pKb value against alpha1A receptor in rat | ChEMBL. | 12672251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.