Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0143 | 0.5002 | 0.5002 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0143 | 0.5002 | 0.4799 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0066 | 0.0942 | 0.1883 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0942 | 0.0574 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Onchocerca volvulus | 0.0066 | 0.0942 | 0.1883 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0066 | 0.0942 | 0.0942 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0942 | 0.0574 |
Schistosoma mansoni | hypothetical protein | 0.0143 | 0.5002 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Onchocerca volvulus | 0.0143 | 0.5002 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0942 | 0.0574 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0066 | 0.0942 | 0.1883 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Onchocerca volvulus | 0.0066 | 0.0942 | 0.1883 | |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0066 | 0.0942 | 0.1883 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0066 | 0.0942 | 0.1883 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0066 | 0.0942 | 0.0574 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 33 % | Inhibition of TGFbeta-induced ALK5 in human HaCaT cells assessed as p3TP-luciferase activity at 0.1 uM | ChEMBL. | 18262787 |
Activity (binding) | = 33 % | Inhibition of TGFbeta-induced ALK5 in human HaCaT cells assessed as p3TP-luciferase activity at 0.1 uM | ChEMBL. | 18262787 |
Activity (binding) | = 64 % | Inhibition of TGFbeta-induced ALK5 in human HaCaT cells assessed as SBE-luciferase activity at 0.1 uM | ChEMBL. | 18262787 |
Activity (binding) | = 64 % | Inhibition of TGFbeta-induced ALK5 in human HaCaT cells assessed as SBE-luciferase activity at 0.1 uM | ChEMBL. | 18262787 |
Activity (binding) | = 68 % | Inhibition of TGFbeta-induced ALK5 in human HaCaT cells assessed as ARE-luciferase activity at 0.1 uM | ChEMBL. | 18262787 |
Activity (binding) | = 68 % | Inhibition of TGFbeta-induced ALK5 in human HaCaT cells assessed as ARE-luciferase activity at 0.1 uM | ChEMBL. | 18262787 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.