Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0401 | 0.4201 | 0.0603 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0401 | 0.4201 | 0.4201 |
Plasmodium vivax | hypothetical protein, conserved | 0.0116 | 0.0167 | 0.5 |
Trypanosoma cruzi | glycosyl hydrolase, putative | 0.0146 | 0.059 | 0.5 |
Brugia malayi | hypothetical protein | 0.0302 | 0.2788 | 0.6637 |
Brugia malayi | Trehalase family protein | 0.0302 | 0.2788 | 0.6637 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2788 | 0.2788 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0401 | 0.4201 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0401 | 0.4201 | 0.0603 |
Mycobacterium tuberculosis | Conserved protein | 0.0146 | 0.059 | 0.5 |
Loa Loa (eye worm) | trehalase | 0.0302 | 0.2788 | 0.2788 |
Schistosoma mansoni | amine GPCR | 0.0728 | 0.8825 | 1 |
Brugia malayi | Trehalase family protein | 0.0302 | 0.2788 | 0.6637 |
Onchocerca volvulus | 0.0302 | 0.2788 | 1 | |
Leishmania major | glycosyl hydrolase, putative | 0.0146 | 0.059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2788 | 0.2788 |
Onchocerca volvulus | Trehalase homolog | 0.0302 | 0.2788 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2788 | 0.2788 |
Loa Loa (eye worm) | trehalase | 0.0302 | 0.2788 | 0.2788 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2788 | 0.2788 |
Trichomonas vaginalis | trehalase, putative | 0.0302 | 0.2788 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2788 | 0.2788 |
Onchocerca volvulus | 0.0302 | 0.2788 | 1 | |
Trypanosoma brucei | glycosyl hydrolase, putative | 0.0146 | 0.059 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0401 | 0.4201 | 1 |
Mycobacterium leprae | Possible hydrolase | 0.0146 | 0.059 | 0.5 |
Mycobacterium ulcerans | glycosyl hydrolase | 0.0146 | 0.059 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0401 | 0.4201 | 1 |
Loa Loa (eye worm) | TRE-2 protein | 0.0302 | 0.2788 | 0.2788 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1311 | 0.1311 |
Onchocerca volvulus | 0.0302 | 0.2788 | 1 | |
Loa Loa (eye worm) | TRE-1 protein | 0.0302 | 0.2788 | 0.2788 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.3904 | 0.3904 |
Brugia malayi | Trehalase family protein | 0.0302 | 0.2788 | 0.6637 |
Loa Loa (eye worm) | trehalase | 0.0302 | 0.2788 | 0.2788 |
Onchocerca volvulus | 0.0302 | 0.2788 | 1 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0401 | 0.4201 | 1 |
Brugia malayi | Trehalase family protein | 0.0302 | 0.2788 | 0.6637 |
Treponema pallidum | hypothetical protein | 0.0104 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0116 | 0.0167 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0302 | 0.2788 | 0.5 |
Onchocerca volvulus | 0.0302 | 0.2788 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 7.03 | Partition coefficient (logP) | ChEMBL. | 6492079 |
pI50 (functional) | = 2.96 mM | Juvenile hormone mimetic activity in Aedes aegypti (yellow-fever mosquito) | ChEMBL. | 6492079 |
pI50 (functional) | = 0.81 uM pupa-1 | Juvenile hormone mimetic activity in Tenebrio molitor (yellow mealworm) | ChEMBL. | 6492079 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.