Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | opioid receptor, mu 1 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 2 | Starlite/ChEMBL | References |
Homo sapiens | solute carrier family 6 (neurotransmitter transporter), member 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 2 | 617 aa | 638 aa | 32.5 % |
Brugia malayi | Sodium:neurotransmitter symporter family protein | solute carrier family 6 (neurotransmitter transporter), member 4 | 630 aa | 574 aa | 31.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0104 | 0.4839 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Schistosoma mansoni | glycogen phosphorylase | 0.0045 | 0.0932 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.3686 | 0.3686 |
Schistosoma mansoni | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0045 | 0.0932 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0182 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0182 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0182 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0104 | 0.4839 | 0.4839 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0104 | 0.4839 | 0.4839 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 1 | 1 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0182 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.4626 | 0.4626 |
Onchocerca volvulus | 0.0101 | 0.4626 | 0.4626 | |
Schistosoma mansoni | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0104 | 0.4839 | 1 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.4626 | 0.4626 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0182 | 1 | 0.5 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.4626 | 0.4626 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0045 | 0.0932 | 0.5 |
Plasmodium vivax | amine transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0182 | 1 | 1 |
Onchocerca volvulus | 0.0101 | 0.4626 | 0.4626 | |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0104 | 0.4839 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.4626 | 0.4626 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4626 | 0.4626 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.4626 | 0.4626 |
Echinococcus granulosus | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0104 | 0.4839 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0031 | 0 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0104 | 0.4839 | 0.4839 |
Giardia lamblia | Glycogen phosphorylase | 0.0104 | 0.4839 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0104 | 0.4839 | 0.5 |
Plasmodium falciparum | amino acid transporter, putative | 0.0031 | 0 | 0.5 |
Plasmodium falciparum | transporter, putative | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Brugia malayi | carbohydrate phosphorylase | 0.0104 | 0.4839 | 0.4839 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0182 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 181 nM | Inhibition of SERT (unknown origin) mediated 5-hydroxytryptamine uptake | ChEMBL. | 18242987 |
IC50 (binding) | = 181 nM | Inhibition of SERT (unknown origin) mediated 5-hydroxytryptamine uptake | ChEMBL. | 18242987 |
IC50 (binding) | = 1010 nM | Inhibition of NET (unknown origin) mediated norepinephrine uptake | ChEMBL. | 18242987 |
IC50 (binding) | = 1010 nM | Inhibition of NET (unknown origin) mediated norepinephrine uptake | ChEMBL. | 18242987 |
IC50 (binding) | > 10000 nM | Binding affinity to mu opioid receptor (unknown origin) | ChEMBL. | 18242987 |
IC50 (binding) | > 10000 nM | Binding affinity to mu opioid receptor (unknown origin) | ChEMBL. | 18242987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.