Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | ADAM17 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 1 (interstitial collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | ADAM17 peptidase (M12 family) | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Schistosoma japonicum | ko:K06059 a disintegrin and metalloproteinase domain 17, putative | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus multilocularis | adam 17 protease | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | Get druggable targets OG5_132656 | All targets in OG5_132656 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | disintegrin and metalloproteinase | ADAM17 | 112 aa | 99 aa | 42.4 % |
Echinococcus multilocularis | disintegrin and metalloproteinase | ADAM17 | 112 aa | 99 aa | 42.4 % |
Trypanosoma congolense | hypothetical protein, conserved | ADAM17 | 112 aa | 100 aa | 29.0 % |
Plasmodium yoelii | A/G-specific adenine glycosylase, putative | ADAM17 | 112 aa | 109 aa | 24.8 % |
Brugia malayi | Matrixin family protein | matrix metallopeptidase 1 (interstitial collagenase) | 403 aa | 401 aa | 27.7 % |
Onchocerca volvulus | Putative glutaminase 3 | ADAM17 | 112 aa | 105 aa | 45.7 % |
Onchocerca volvulus | ADAM17 | 112 aa | 98 aa | 41.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0152 | 0 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0263 | 0.2747 | 0.0466 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0294 | 0.3511 | 0.147 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0294 | 0.3511 | 0.147 |
Echinococcus multilocularis | adam 17 protease | 0.0557 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.3511 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0152 | 0 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0557 | 1 | 1 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0263 | 0.2747 | 0.0466 |
Loa Loa (eye worm) | matrixin family protein | 0.0165 | 0.0337 | 0.0961 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0263 | 0.2747 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.3 nM | Inhibition of pig TACE | ChEMBL. | 18061445 |
IC50 (binding) | = 1.3 nM | Inhibition of pig TACE | ChEMBL. | 18061445 |
IC50 (functional) | = 66 nM | Inhibition of LPS-stimulated TNFalpha release in human whole blood | ChEMBL. | 18061445 |
IC50 (functional) | = 66 nM | Inhibition of LPS-stimulated TNFalpha release in human whole blood | ChEMBL. | 18061445 |
Ki (binding) | = 1700 nM | Binding affinity to MMP2 (unknown origin) | ChEMBL. | 18061445 |
Ki (binding) | = 1700 nM | Binding affinity to MMP2 (unknown origin) | ChEMBL. | 18061445 |
Ki (binding) | > 2128 nM | Binding affinity to MMP9 (unknown origin) | ChEMBL. | 18061445 |
Ki (binding) | > 2128 nM | Binding affinity to MMP9 (unknown origin) | ChEMBL. | 18061445 |
Ki (binding) | > 4948 nM | Binding affinity to MMP1 (unknown origin) | ChEMBL. | 18061445 |
Ki (binding) | > 4948 nM | Binding affinity to MMP1 (unknown origin) | ChEMBL. | 18061445 |
Papp (ADMET) | = 0.2 10^-6 cm/s | Apparent permeability from apical to basolateral side of human Caco2 cell membrane | ChEMBL. | 18061445 |
Papp (ADMET) | = 0.2 10^-6 cm/s | Apparent permeability from apical to basolateral side of human Caco2 cell membrane | ChEMBL. | 18061445 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18061445 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.