Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0287 | 0.264 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0665 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0665 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0665 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0665 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0 | 0.5 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0665 | 1 | 1 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0665 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0665 | 1 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0665 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0665 | 1 | 0.5 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0665 | 1 | 0.5 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0665 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0665 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0665 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0665 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0287 | 0.264 | 0.5 |
Echinococcus granulosus | glycogen phosphorylase | 0.0665 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0665 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.3 uM | Inhibition of p38alpha (unknown origin) by fluorescence polarization assay | ChEMBL. | 17981461 |
IC50 (binding) | = 2.3 uM | Inhibition of p38alpha (unknown origin) by fluorescence polarization assay | ChEMBL. | 17981461 |
Ki (binding) | = 0.36 uM | Inhibition of p38alpha (unknown origin) by fluorescence polarization assay | ChEMBL. | 17981461 |
Ki (binding) | = 0.36 uM | Inhibition of p38alpha (unknown origin) by fluorescence polarization assay | ChEMBL. | 17981461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.