Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Homo sapiens | phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | Phenylethanolamine N-methyltransferase | 283 aa | 245 aa | 26.5 % |
Brugia malayi | NNMT/PNMT/TEMT family protein | Phenylethanolamine N-methyltransferase | 283 aa | 254 aa | 26.0 % |
Brugia malayi | NNMT/PNMT/TEMT family protein | phenylethanolamine N-methyltransferase | 282 aa | 257 aa | 26.5 % |
Onchocerca volvulus | Putative Werner syndrome ATP-dependent helicase homolog 1 | Phenylethanolamine N-methyltransferase | 283 aa | 254 aa | 27.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.2953 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1417 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.1569 | 0.1027 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0259 | 0.2953 | 0.2953 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.017 | 0.141 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0497 | 0.0497 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.2953 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.2953 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0259 | 0.2953 | 0.2953 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0179 | 0.1569 | 0.1027 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0667 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0667 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0089 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.2953 | 1 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1417 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.2953 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0259 | 0.2953 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.1417 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0117 | 0.0497 | 0.0497 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.7 uM | Affinity for bovine Phenylethanolamine N-Methyltransferase (PNMT) | ChEMBL. | 10479290 |
Ki (binding) | = 1.7 uM | Inhibitory constant against bovine phenylethanolamine N-methyltransferase | ChEMBL. | 11412985 |
Ki (binding) | = 1.7 uM | Affinity for bovine Phenylethanolamine N-Methyltransferase (PNMT) | ChEMBL. | 10479290 |
Ki (binding) | = 1.7 uM | Inhibitory constant against bovine phenylethanolamine N-methyltransferase | ChEMBL. | 11412985 |
Ki (binding) | = 3.5 uM | Inhibitory constant against human phenylethanolamine N-methyltransferase overexpressed in E. coli | ChEMBL. | 11412985 |
Ki (binding) | = 3.5 uM | Inhibitory constant against human phenylethanolamine N-methyltransferase overexpressed in E. coli | ChEMBL. | 11412985 |
Ki (binding) | = 47 uM | Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor | ChEMBL. | 10479290 |
Ki (binding) | = 47 uM | Compound was tested in vitro for its affinity towards rat Alpha-2 adrenergic receptor | ChEMBL. | 10479290 |
Ratio (binding) | = 2.1 | Ki ratio of human versus bovine phenylethanolamine N-methyltransferase | ChEMBL. | 11412985 |
Ratio (binding) | = 28 | Ratio for binding affinity towards alpha2 adenoceptor to PNMT | ChEMBL. | 10479290 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.