Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | lipase | 0.0911 | 0.6256 | 0.6256 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0911 | 0.6256 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0164 | 0 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0911 | 0.6256 | 1 |
Plasmodium vivax | glutamyl-tRNA(Gln) amidotransferase subunit A, putative | 0.0164 | 0 | 0.5 |
Plasmodium falciparum | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0164 | 0 | 0.5 |
Onchocerca volvulus | 0.0911 | 0.6256 | 0.5 | |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0164 | 0 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0911 | 0.6256 | 0.5 |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0911 | 0.6256 | 0.6256 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1359 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0911 | 0.6256 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1359 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0292 | 0.107 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0911 | 0.6256 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0164 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0292 | 0.107 | 1 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0911 | 0.6256 | 0.6256 |
Trypanosoma brucei | lipase domain protein, putative | 0.0911 | 0.6256 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0164 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.1359 | 1 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0164 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.1359 | 1 | 1 |
Brugia malayi | Lipase family protein | 0.0911 | 0.6256 | 0.6256 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0911 | 0.6256 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1359 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.1359 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.1359 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (functional) | < 5 | Compound was evaluated for its antagonist affinity at 10 (microM) on guinea-pig trachea rings against LTD4 receptor | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.