Detailed information for compound 53648

Basic information

Technical information
  • TDR Targets ID: 53648
  • Name: N-(2-oxopyrrolidin-3-yl)formamide
  • MW: 128.129 | Formula: C5H8N2O2
  • H donors: 2 H acceptors: 2 LogP: -0.35 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CNC1CCNC1=O
  • InChi: 1S/C5H8N2O2/c8-3-7-4-1-2-6-5(4)9/h3-4H,1-2H2,(H,6,9)(H,7,8)
  • InChiKey: XZQFGMJAIGQKHP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-oxo-3-pyrrolidinyl)formamide
  • N-(2-oxopyrrolidin-3-yl)methanamide
  • N-(2-ketopyrrolidin-3-yl)formamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cysteine peptidase A (CPA) 0.012 0.0732 0.1707
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0298 0.4243 1
Brugia malayi Papain family cysteine protease containing protein 0.012 0.0732 0.1066
Toxoplasma gondii cathepsin B 0.0112 0.057 0.1279
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0298 0.4243 0.4243
Echinococcus multilocularis cysteine protease 0.012 0.0732 0.1557
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0431 0.6873 0.6873
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0431 0.6873 0.6873
Loa Loa (eye worm) hypothetical protein 0.0298 0.4243 0.6173
Brugia malayi Kringle domain containing protein 0.0088 0.0085 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.012 0.0732 0.0732
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0135 0.1022 0.2253
Loa Loa (eye worm) hypothetical protein 0.0088 0.0085 0.0124
Echinococcus multilocularis cysteine protease 0.012 0.0732 0.1557
Entamoeba histolytica cysteine proteinase, putative 0.012 0.0732 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Onchocerca volvulus 0.012 0.0732 0.1066
Loa Loa (eye worm) hypothetical protein 0.028 0.3879 0.5645
Brugia malayi Trypsin family protein 0.0431 0.6873 1
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0732 0.1726
Entamoeba histolytica cysteine protease, putative 0.012 0.0732 1
Loa Loa (eye worm) hypothetical protein 0.0431 0.6873 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.012 0.0732 0.1066
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Echinococcus multilocularis cathepsin b 0.0298 0.4243 1
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.028 0.3879 1
Giardia lamblia Cathepsin B precursor 0.0112 0.057 0.5
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.4243 0.4243
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.028 0.3879 0.3879
Brugia malayi Cathepsin L-like precursor 0.012 0.0732 0.1066
Onchocerca volvulus 0.0088 0.0085 0.0124
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0112 0.057 0.1344
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.012 0.0732 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Toxoplasma gondii prolyl endopeptidase 0.028 0.3879 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Loa Loa (eye worm) cysteine protease 0.012 0.0732 0.1066
Plasmodium vivax vivapain-2 0.012 0.0732 1
Onchocerca volvulus 0.012 0.0732 0.1066
Echinococcus multilocularis cathepsin l cysteine peptidase 0.012 0.0732 0.1557
Onchocerca volvulus Cathepsin F homolog 0.012 0.0732 0.1066
Loa Loa (eye worm) hypothetical protein 0.0431 0.6873 1
Brugia malayi Cathepsin L-like precursor 0.012 0.0732 0.1066
Giardia lamblia Cathepsin B precursor 0.0112 0.057 0.5
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0111 0.055 0.1297
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0085 0.02
Onchocerca volvulus 0.0431 0.6873 1
Echinococcus granulosus tissue type plasminogen activator 0.0088 0.0085 0.02
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Brugia malayi prolyl oligopeptidase family protein 0.028 0.3879 0.5645
Onchocerca volvulus 0.012 0.0732 0.1066
Trypanosoma cruzi prolyl endopeptidase 0.028 0.3879 0.9144
Trypanosoma cruzi oligopeptidase b 0.0111 0.055 0.1297
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.012 0.0732 0.1066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Echinococcus multilocularis cathepsin L cysteine protease 0.012 0.0732 0.1557
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.028 0.3879 0.3879
Loa Loa (eye worm) hypothetical protein 0.0091 0.0148 0.0216
Entamoeba histolytica cysteine proteinase, putative 0.012 0.0732 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Loa Loa (eye worm) hypothetical protein 0.012 0.0732 0.1066
Echinococcus granulosus prolyl endopeptidase 0.028 0.3879 0.9144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Echinococcus granulosus cathepsin l cysteine peptidase 0.012 0.0732 0.1726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Toxoplasma gondii cathepsin CPL 0.012 0.0732 0.1707
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.025 0.33 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Echinococcus granulosus microsomal glutathione S transferase 3 0.0135 0.1022 0.2408
Schistosoma mansoni hypothetical protein 0.0088 0.0085 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Echinococcus multilocularis cathepsin L cysteine protease 0.012 0.0732 0.1557
Loa Loa (eye worm) fibroinase 0.012 0.0732 0.1066
Loa Loa (eye worm) cathepsin B 0.0112 0.057 0.083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.4243 0.4243
Giardia lamblia Cathepsin B precursor 0.0112 0.057 0.5
Plasmodium falciparum cysteine proteinase falcipain 2b 0.012 0.0732 1
Onchocerca volvulus Cathepsin L homolog 0.012 0.0732 0.1066
Onchocerca volvulus Prolyl endopeptidase homolog 0.028 0.3879 0.5645
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0091 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.012 0.0732 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0112 0.057 0.1279
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0112 0.057 0.057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trypanosoma cruzi oligopeptidase b 0.0111 0.055 0.1297
Brugia malayi Cathepsin L-like precursor 0.012 0.0732 0.1066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Brugia malayi Cathepsin L-like precursor 0.012 0.0732 0.1066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Brugia malayi Protein kinase domain containing protein 0.0088 0.0085 0.0124
Loa Loa (eye worm) hypothetical protein 0.0091 0.0148 0.0216
Brugia malayi Cathepsin L-like precursor 0.012 0.0732 0.1066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0732 0.1726
Onchocerca volvulus Cathepsin L homolog 0.012 0.0732 0.1066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Leishmania major oligopeptidase b 0.0111 0.055 0.1227
Brugia malayi Cathepsin L-like precursor 0.012 0.0732 0.1066
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0111 0.055 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.012 0.0732 0.1557
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0091 0.0148 0.0152
Toxoplasma gondii MAPEG family protein 0.0135 0.1022 0.2469
Onchocerca volvulus 0.012 0.0732 0.1066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Onchocerca volvulus 0.0384 0.5933 0.8633
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0298 0.4243 0.4243
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0111 0.055 0.1297
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0112 0.057 0.0059
Echinococcus granulosus cathepsin b 0.0298 0.4243 1
Onchocerca volvulus 0.012 0.0732 0.1066
Trypanosoma cruzi cruzipain precursor, putative 0.012 0.0732 0.1726
Loa Loa (eye worm) ctsf protein 0.012 0.0732 0.1066
Plasmodium falciparum cysteine proteinase falcipain 3 0.012 0.0732 1
Onchocerca volvulus 0.012 0.0732 0.1066
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0111 0.055 0.1227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Plasmodium vivax vivapain-2 0.012 0.0732 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0148 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0091 0.0148 0.0349
Trypanosoma brucei prolyl endopeptidase 0.028 0.3879 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.012 0.0732 0.1726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Echinococcus granulosus cathepsin l1 0.012 0.0732 0.1726
Loa Loa (eye worm) TK/ROR protein kinase 0.0088 0.0085 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0732 0.1726
Brugia malayi cathepsin B-like cysteine proteinase 0.0298 0.4243 0.6173
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0112 0.057 0.7784
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.012 0.0732 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Brugia malayi Serine carboxypeptidase S28 family protein 0.0091 0.0148 0.0216
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0111 0.055 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.012 0.0732 0.0547
Echinococcus multilocularis cathepsin b 0.0298 0.4243 1
Trypanosoma cruzi cysteine peptidase, putative 0.012 0.0732 0.1726
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.012 0.0732 1
Onchocerca volvulus 0.012 0.0732 0.1066
Plasmodium falciparum cysteine proteinase falcipain 2a 0.012 0.0732 1
Schistosoma mansoni microsomal glutathione s-transferase 0.0135 0.1022 0.1022
Schistosoma mansoni cathepsin F (C01 family) 0.012 0.0732 0.0732
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Echinococcus multilocularis prolyl endopeptidase 0.028 0.3879 0.9126
Leishmania major cathepsin L-like protease 0.012 0.0732 0.1707
Echinococcus granulosus cathepsin b 0.0298 0.4243 1

Activities

Activity type Activity value Assay description Source Reference
AA (functional) = 0 Amnesia-reversal activity evaluated in scopolamine-induced amnesia model of mice at a dose of 1 mg/kg ChEMBL. 8496921
AA (functional) = 9 Amnesia-reversal activity evaluated in ECS-induced amnesia model of mice at a dose of 10 mg/kg ChEMBL. 8496921
AA (functional) = 53 Amnesia-reversal activity evaluated in ECS-induced amnesia model of mice at a dose of 1 mg/kg ChEMBL. 8496921
AA (functional) = 0 Amnesia-reversal activity evaluated in scopolamine-induced amnesia model of mice at a dose of 1 mg/kg ChEMBL. 8496921
AA (functional) = 9 Amnesia-reversal activity evaluated in ECS-induced amnesia model of mice at a dose of 10 mg/kg ChEMBL. 8496921
AA (functional) = 53 Amnesia-reversal activity evaluated in ECS-induced amnesia model of mice at a dose of 1 mg/kg ChEMBL. 8496921

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.