Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | flavodoxin domain containing protein | 0.0555 | 0.6456 | 0.8717 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0626 | 0.7406 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0626 | 0.7406 | 1 |
Trypanosoma brucei | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0239 | 0.2246 | 0.3033 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0626 | 0.7406 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.031 | 0.3196 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0239 | 0.2246 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0239 | 0.2246 | 0.3033 |
Echinococcus granulosus | methionine synthase reductase | 0.0386 | 0.421 | 0.5684 |
Giardia lamblia | Hypothetical protein | 0.0555 | 0.6456 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0626 | 0.7406 | 0.7406 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0386 | 0.421 | 0.5684 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.031 | 0.3196 | 1 |
Brugia malayi | flavodoxin family protein | 0.0626 | 0.7406 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0626 | 0.7406 | 1 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0555 | 0.6456 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0071 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable monooxygenase | 0.0071 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0626 | 0.7406 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0315 | 0.326 | 0.4402 |
Plasmodium vivax | hypothetical protein, conserved | 0.0239 | 0.2246 | 0.3033 |
Leishmania major | p450 reductase, putative | 0.0626 | 0.7406 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0626 | 0.7406 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0626 | 0.7406 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0071 | 0 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0626 | 0.7406 | 1 |
Treponema pallidum | flavodoxin | 0.0239 | 0.2246 | 1 |
Leishmania major | cytochrome P450 reductase, putative | 0.0555 | 0.6456 | 0.8717 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0239 | 0.2246 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0239 | 0.2246 | 0.5 |
Mycobacterium tuberculosis | Possible oxygenase | 0.0071 | 0 | 0.5 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0239 | 0.2246 | 0.5 |
Mycobacterium tuberculosis | Hypothetical oxidoreductase | 0.0071 | 0 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0626 | 0.7406 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0626 | 0.7406 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0626 | 0.7406 | 1 |
Brugia malayi | flavodoxin family protein | 0.0239 | 0.2246 | 0.3033 |
Trypanosoma cruzi | p450 reductase, putative | 0.0626 | 0.7406 | 1 |
Trypanosoma cruzi | NADPH--cytochrome P450 reductase, putative | 0.0239 | 0.2246 | 0.3033 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0626 | 0.7406 | 1 |
Schistosoma mansoni | diflavin oxidoreductase | 0.031 | 0.3196 | 0.4316 |
Trypanosoma cruzi | Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative | 0.0239 | 0.2246 | 0.3033 |
Plasmodium falciparum | S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative | 0.0239 | 0.2246 | 0.3033 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0239 | 0.2246 | 0.5 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0555 | 0.6456 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0386 | 0.421 | 0.5684 |
Onchocerca volvulus | 0.0071 | 0 | 0.5 | |
Chlamydia trachomatis | sulfite reductase | 0.0386 | 0.421 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0626 | 0.7406 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0626 | 0.7406 | 1 |
Loa Loa (eye worm) | flavodoxin family protein | 0.0239 | 0.2246 | 0.3033 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0386 | 0.421 | 0.5684 |
Loa Loa (eye worm) | hypothetical protein | 0.0626 | 0.7406 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0626 | 0.7406 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0626 | 0.7406 | 0.7406 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0239 | 0.2246 | 0.5 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0626 | 0.7406 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0386 | 0.421 | 0.421 |
Plasmodium falciparum | NADPH--cytochrome P450 reductase, putative | 0.0239 | 0.2246 | 0.3033 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0626 | 0.7406 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.