TDR Targets

Basic information

Technical information

TDR Targets ID: 551196
Name: (E)-heptadec-15-enoic acid
MW: 268.435 | Formula: C17H32O2
H donors: 1 H acceptors: 2 LogP: 6.83 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: C/C=C/CCCCCCCCCCCCCC(=O)O
InChi: 1S/C17H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(18)19/h2-3H,4-16H2,1H3,(H,18,19)/b3-2+
InChiKey: QCIGIZBRIXIGRF-NSCUHMNNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(E)-15-heptadecenoic acid
E-15-Heptadecenoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Echinococcus multilocularis	geminin	0.0385	0.3919	0.3919
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.012	0.0928	1
Entamoeba histolytica	cysteine proteinase, putative	0.0069	0.0354	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Schistosoma mansoni	cathepsin F (C01 family)	0.0047	0.0113	0.0158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Plasmodium vivax	thioredoxin reductase, putative	0.0047	0.0111	0.3126
Echinococcus granulosus	cathepsin b	0.0145	0.1211	0.168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.008	0.0482	0.0669
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0354	0.2924
Echinococcus granulosus	GPCR family 2	0.008	0.0482	0.0669
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0056	0.0208	0.3989
Onchocerca volvulus		0.0069	0.0354	0.108
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0354	0.2924
Loa Loa (eye worm)	TAR-binding protein	0.0323	0.3215	1
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0354	0.1102
Onchocerca volvulus	Cathepsin L homolog	0.0069	0.0354	0.108
Loa Loa (eye worm)	hypothetical protein	0.0173	0.153	0.4574
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Trypanosoma brucei	trypanothione reductase	0.0047	0.0111	0.3126
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.008	0.0482	0.0669
Schistosoma mansoni	tar DNA-binding protein	0.0323	0.3215	0.4498
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0696	0.1886
Onchocerca volvulus	Cathepsin L homolog	0.0069	0.0354	0.108
Onchocerca volvulus		0.0069	0.0354	0.108
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Onchocerca volvulus		0.0069	0.0354	0.108
Loa Loa (eye worm)	hypothetical protein	0.008	0.0482	0.1196
Schistosoma mansoni	cellular tumor antigen P53	0.0099	0.0696	0.0974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0069	0.0354	1
Entamoeba histolytica	cysteine protease, putative	0.0069	0.0354	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0069	0.0354	0.0496
Plasmodium falciparum	thioredoxin reductase	0.0047	0.0111	0.3126
Loa Loa (eye worm)	fibroinase	0.0069	0.0354	0.0784
Brugia malayi	cathepsin B-like cysteine proteinase	0.0145	0.1211	0.3768
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.2013	0.6128
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0056	0.0208	0.1716
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.008	0.0482	0.15
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.1211	0.1695
Plasmodium vivax	vivapain-2	0.0069	0.0354	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0069	0.0354	0.0784
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0069	0.0354	0.0784
Echinococcus multilocularis	cysteine protease	0.0069	0.0354	0.0354
Loa Loa (eye worm)	cysteine protease	0.0069	0.0354	0.0784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0354	0.1102
Echinococcus multilocularis	cathepsin b	0.0145	0.1211	0.1211
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Trichomonas vaginalis	set domain proteins, putative	0.0246	0.2349	1
Echinococcus granulosus	tumor protein p63	0.0677	0.7212	1
Brugia malayi	RNA binding protein	0.0323	0.3215	1
Echinococcus granulosus	cathepsin b	0.0145	0.1211	0.168
Giardia lamblia	Cathepsin B precursor	0.0056	0.0208	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0069	0.0354	1
Loa Loa (eye worm)	ctsf protein	0.0069	0.0354	0.0784
Leishmania major	cysteine peptidase A (CPA)	0.0069	0.0354	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.012	0.0928	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0113	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0354	0.1102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Schistosoma mansoni	hypothetical protein	0.0173	0.153	0.2141
Brugia malayi	Papain family cysteine protease containing protein	0.0069	0.0354	0.1102
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Plasmodium vivax	glutathione reductase, putative	0.0047	0.0111	0.3126
Trypanosoma cruzi	trypanothione reductase, putative	0.0047	0.0111	0.0914
Brugia malayi	Thioredoxin reductase	0.0047	0.0111	0.0344
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Echinococcus granulosus	thioredoxin glutathione reductase	0.0047	0.0111	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0113	0.0006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0047	0.0111	0.0111
Echinococcus granulosus	geminin	0.0385	0.3919	0.5435
Onchocerca volvulus		0.0246	0.2349	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.012	0.0928	1
Echinococcus multilocularis	tar DNA binding protein	0.0323	0.3215	0.3215
Mycobacterium tuberculosis	Probable dehydrogenase	0.0108	0.0792	0.8342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0069	0.0354	0.1508
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.1211	0.1695
Onchocerca volvulus		0.0069	0.0354	0.108
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0069	0.0354	0.0354
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Giardia lamblia	Cathepsin B precursor	0.0056	0.0208	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0253	0.2434	0.7571
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.7147	0.7147
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0253	0.2434	0.7571
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0069	0.0354	0.0491
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0323	0.3215	1
Schistosoma mansoni	tar DNA-binding protein	0.0323	0.3215	0.4498
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0354	0.1102
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0108	0.0792	0.8342
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.008	0.0482	0.0482
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Schistosoma mansoni	hypothetical protein	0.0385	0.3919	0.5484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Schistosoma mansoni	hypothetical protein	0.008	0.0482	0.0675
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Schistosoma mansoni	tar DNA-binding protein	0.0323	0.3215	0.4498
Echinococcus granulosus	cathepsin l1	0.0069	0.0354	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0253	0.2434	0.7484
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Trypanosoma cruzi	cruzipain precursor, putative	0.0069	0.0354	0.2924
Toxoplasma gondii	cathepsin CPL	0.0069	0.0354	1
Brugia malayi	RNA recognition motif domain containing protein	0.0323	0.3215	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0113	0.0006
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0069	0.0354	0.0354
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0069	0.0354	0.1508
Plasmodium vivax	vivapain-2	0.0069	0.0354	1
Mycobacterium tuberculosis	Probable reductase	0.0108	0.0792	0.8342
Brugia malayi	cathepsin L-like precursor	0.0047	0.0113	0.0351
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0354	0.1102
Schistosoma mansoni	hypothetical protein	0.008	0.0482	0.0675
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Giardia lamblia	Cathepsin B precursor	0.0056	0.0208	0.5
Echinococcus multilocularis	cysteine protease	0.0069	0.0354	0.0354
Echinococcus granulosus	cathepsin l1	0.0047	0.0113	0.0156
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Echinococcus multilocularis	tumor protein p63	0.0677	0.7212	0.7212
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0113	0.048
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0108	0.0792	0.8342
Onchocerca volvulus		0.0069	0.0354	0.108
Schistosoma mansoni	hypothetical protein	0.0385	0.3919	0.5484
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Echinococcus multilocularis	cathepsin b	0.0145	0.1211	0.1211
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0354	0.2924
Brugia malayi	TAR-binding protein	0.0323	0.3215	1
Brugia malayi	Cathepsin L-like precursor	0.0069	0.0354	0.1102
Onchocerca volvulus		0.0069	0.0354	0.108
Schistosoma mansoni	hypothetical protein	0.008	0.0482	0.0675
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0108	0.0792	0.8342
Toxoplasma gondii	cathepsin B	0.0056	0.0208	0.3989
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0145	0.1211	0.1695
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0113	0.0351
Schistosoma mansoni	tar DNA-binding protein	0.0323	0.3215	0.4498
Brugia malayi	glutathione reductase	0.0047	0.0111	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0354	0.0784
Plasmodium falciparum	glutathione reductase	0.0047	0.0111	0.3126
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0069	0.0354	0.1508
Echinococcus multilocularis	cathepsin L cysteine protease	0.0069	0.0354	0.0354
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.012	0.0928	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0069	0.0354	0.0496
Entamoeba histolytica	cysteine proteinase, putative	0.0069	0.0354	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0069	0.0354	0.0491
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.7147	1
Schistosoma mansoni	hypothetical protein	0.008	0.0482	0.0675
Brugia malayi	latrophilin 2 splice variant baaae	0.0173	0.153	0.4761
Brugia malayi	Latrophilin receptor protein 2	0.008	0.0482	0.15
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0253	0.2434	0.7484
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0047	0.0113	0.0351
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.7147	0.991
Loa Loa (eye worm)	hypothetical protein	0.0145	0.1211	0.3546
Echinococcus granulosus	tar DNA binding protein	0.0323	0.3215	0.4457
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0145	0.1211	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0108	0.0792	0.8342
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0069	0.0354	1
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0113	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0056	0.0208	0.0885
Loa Loa (eye worm)	cathepsin B	0.0056	0.0208	0.0313
Brugia malayi	Cathepsin L-like precursor	0.0047	0.0113	0.0351
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0113	0.048
Schistosoma mansoni	tar DNA-binding protein	0.0323	0.3215	0.4498
Onchocerca volvulus	Cathepsin F homolog	0.0069	0.0354	0.108
Onchocerca volvulus		0.0099	0.0696	0.2608
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0056	0.0208	0.0291
Loa Loa (eye worm)	RNA binding protein	0.0323	0.3215	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Onchocerca volvulus		0.0069	0.0354	0.108
Brugia malayi	Pre-SET motif family protein	0.0216	0.2013	0.6262
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0069	0.0354	0.1508
Leishmania major	cathepsin L-like protease	0.0069	0.0354	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0056	0.0208	0.5868
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0069	0.0354	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0069	0.0354	0.2924
Loa Loa (eye worm)	latrophilin receptor protein 2	0.008	0.0482	0.1196
Echinococcus multilocularis	cathepsin L cysteine protease	0.0069	0.0354	0.0354
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.008	0.0482	0.0482
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0145	0.1211	0.1695
Echinococcus multilocularis	GPCR, family 2	0.008	0.0482	0.0482
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0047	0.0113	0.093

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 5363220

Bibliographic References

No literature references available for this target.

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Detailed information for compound 551196