Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | beta galactosidase | 0.0126 | 0.063 | 0.063 |
Echinococcus granulosus | beta galactosidase | 0.0126 | 0.063 | 0.063 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0952 | 1 | 0.5 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0952 | 1 | 1 |
Echinococcus multilocularis | caspase | 0.0096 | 0.0292 | 0.0292 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0252 | 0.2064 | 0.5 |
Echinococcus granulosus | sentrin specific protease 7 | 0.0143 | 0.0826 | 0.0826 |
Echinococcus granulosus | caspase | 0.0096 | 0.0292 | 0.0292 |
Loa Loa (eye worm) | hypothetical protein | 0.047 | 0.4533 | 0.7652 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0575 | 0.573 | 0.5 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0575 | 0.573 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.0131 | 0.0684 | 0.0684 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0096 | 0.0292 | 0.0292 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0252 | 0.2064 | 0.5 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0143 | 0.0826 | 0.0981 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0143 | 0.0826 | 0.5 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0096 | 0.0292 | 0.0292 |
Echinococcus multilocularis | sentrin specific protease 7 | 0.0143 | 0.0826 | 0.0826 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0575 | 0.573 | 1 |
Schistosoma mansoni | beta-galactosidase | 0.0126 | 0.063 | 0.0621 |
Echinococcus multilocularis | expressed conserved protein | 0.0131 | 0.0684 | 0.0684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.