Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0189 | 0.5341 | 0.5341 |
Brugia malayi | Bromodomain containing protein | 0.0059 | 0.0314 | 0.0314 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0122 | 0.2757 | 0.2757 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 0.2757 | 0.3251 |
Brugia malayi | Pre-SET motif family protein | 0.0203 | 0.5882 | 0.5882 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0439 | 0.0439 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0155 | 0.4004 | 0.4004 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0439 | 0.0518 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0082 | 0.1198 | 0.1198 |
Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.0051 | 0 | 0.5 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0148 | 0.3741 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0189 | 0.5341 | 0.6297 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0189 | 0.5341 | 0.6297 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.018 | 0.4987 | 0.4987 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0314 | 0.0534 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0439 | 0.0518 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4004 | 0.6807 |
Schistosoma mansoni | lipoxygenase | 0.0054 | 0.0133 | 0.0157 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0439 | 0.0747 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0439 | 0.0439 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0439 | 0.0439 |
Echinococcus granulosus | muscleblind protein | 0.0155 | 0.4004 | 0.4004 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0303 | 0.9691 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0439 | 0.0518 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0189 | 0.5341 | 0.5341 |
Echinococcus granulosus | geminin | 0.0166 | 0.4428 | 0.4428 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0059 | 0.0314 | 0.0534 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0059 | 0.0314 | 0.0314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0439 | 0.0518 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.4428 | 0.5221 |
Plasmodium vivax | hypothetical protein, conserved | 0.0059 | 0.0314 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0303 | 0.9691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.4797 | 0.8156 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0054 | 0.0133 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0059 | 0.0314 | 0.0371 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0439 | 0.0439 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0148 | 0.3741 | 0.2491 |
Echinococcus granulosus | peregrin | 0.0059 | 0.0314 | 0.0314 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0439 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.4004 | 0.6807 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.314 | 0.5339 |
Brugia malayi | Muscleblind-like protein | 0.0155 | 0.4004 | 0.4004 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0051 | 0 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.4428 | 0.5221 |
Brugia malayi | jmjC domain containing protein | 0.0189 | 0.5341 | 0.5341 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0059 | 0.0314 | 0.0371 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0148 | 0.3741 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0059 | 0.0314 | 1 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0439 | 0.0439 |
Brugia malayi | Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog | 0.0175 | 0.4797 | 0.4797 |
Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.0051 | 0 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0059 | 0.0314 | 0.0314 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0439 | 0.0747 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0311 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0439 | 0.0747 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Onchocerca volvulus | 0.0232 | 0.6963 | 1 | |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.018 | 0.4987 | 0.8479 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0122 | 0.2757 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0271 | 0.8481 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0121 | 0.2717 | 0.4619 |
Trichomonas vaginalis | set domain proteins, putative | 0.0232 | 0.6963 | 0.4627 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0122 | 0.2757 | 0.2757 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0189 | 0.5341 | 0.9081 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0082 | 0.1198 | 0.1198 |
Echinococcus multilocularis | peregrin | 0.0059 | 0.0314 | 0.0314 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0122 | 0.2757 | 1 |
Echinococcus multilocularis | geminin | 0.0166 | 0.4428 | 0.4428 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0054 | 0.0133 | 0.0133 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0122 | 0.2757 | 0.3251 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0059 | 0.0314 | 0.0314 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0059 | 0.0314 | 0.114 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0203 | 0.5882 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0155 | 0.4004 | 0.4004 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0059 | 0.0314 | 0.114 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.6705 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0303 | 0.9691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4987 | 0.8479 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 27.306 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 30.8956 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 54.941 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 54.941 uM | PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 68.5896 uM | PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.