Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.4176 | 1 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0074 | 0 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.4176 | 1 | 1 |
Giardia lamblia | CDC8 | 0.0074 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4176 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0074 | 0 | 0.5 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.1758 | 0.4105 | 0.4105 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.4176 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.4176 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.4176 | 1 | 1 |
Onchocerca volvulus | 0.4176 | 1 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4176 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.1987 | 0.4663 | 0.4663 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.4176 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.4176 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.1987 | 0.4663 | 0.4663 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.1758 | 0.4105 | 0.4105 |
Echinococcus granulosus | thymidylate synthase | 0.4176 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1987 | 0.4663 | 1 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0074 | 0 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.4176 | 1 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.1758 | 0.4105 | 0.4105 |
Mycobacterium ulcerans | thymidylate synthase | 0.4176 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1987 | 0.4663 | 0.4663 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.4176 | 1 | 1 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0074 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.607 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.529 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.302 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.258 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.198 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
IC50 (functional) | = 296 nM | Cytotoxicity against human HL60 cells after 48 hrs by trypan blue exclusion method | ChEMBL. | 8864242 |
IC50 (functional) | = 0.2 uM | Compound was evaluated in vitro for antitumor activity against A549 (lung) human tumor cell lines. | ChEMBL. | No reference |
IC50 (functional) | = 0.3 uM | Compound was evaluated in vitro for antitumor activity against SW480 (colon) human tumor cell lines. | ChEMBL. | No reference |
IC50 (functional) | = 0.45 uM | Compound was evaluated in vitro for antitumor activity against MB-231 (breast) human tumor cell lines. | ChEMBL. | No reference |
IC50 (functional) | = 0.55 uM | Compound was evaluated in vitro for antitumor activity against A375 (melanoma) human tumor cell lines. | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8864242 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.