Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | methylthioadenosine phosphorylase, putative | purine nucleoside phosphorylase | 289 aa | 255 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.035 | 1 | 1 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.035 | 1 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.035 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3295 | 0.3295 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | endoplasmic reticulum mannosyl oligosaccharide | 0.0197 | 0.3295 | 0.3295 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.035 | 1 | 1 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0154 | 0.1395 | 0.5 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.035 | 1 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0154 | 0.1395 | 0.5 |
Echinococcus granulosus | mannosyl oligosaccharide 12 alpha mannosidase | 0.0197 | 0.3295 | 0.3295 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus multilocularis | transfer RNA-Trp | 0.0197 | 0.3295 | 0.3295 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0197 | 0.3295 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.035 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus granulosus | endoplasmic reticulum mannosyl oligosaccharide | 0.0197 | 0.3295 | 0.3295 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Loa Loa (eye worm) | mannosidase | 0.0197 | 0.3295 | 0.3295 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Echinococcus multilocularis | mannosyl oligosaccharide 1,2 alpha mannosidase | 0.0197 | 0.3295 | 0.3295 |
Brugia malayi | Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform 1 | 0.0197 | 0.3295 | 0.2207 |
Trichomonas vaginalis | endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.3295 | 0.3295 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.2104 | 0.2104 |
Onchocerca volvulus | 0.0235 | 0.4967 | 1 | |
Schistosoma mansoni | mannosyl-oligosaccharide alpha-12-mannosidase | 0.0197 | 0.3295 | 0.2207 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0154 | 0.1395 | 0.1395 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0154 | 0.1395 | 0.5 |
Trichomonas vaginalis | mannosyl-oligosaccharide alpha-1,2-mannosidase, putative | 0.0197 | 0.3295 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.4 uM | Compound was tested for the inhibitory activity against purine nucleoside phosphorylase (PNP) | ChEMBL. | 1578487 |
IC50 (binding) | = 5.4 uM | Compound was tested for the inhibitory activity against purine nucleoside phosphorylase (PNP) | ChEMBL. | 1578487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.