Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.1099 | 0.6349 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1099 | 0.3417 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1099 | 0.0918 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0016 | 0.02 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1099 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2833 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.1312 | 0.4225 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1757 | 0.5913 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1099 | 0.8087 |
Plasmodium falciparum | M18 aspartyl aminopeptidase | 0.0072 | 0.2833 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1312 | 0.4225 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1099 | 0.3417 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0016 | 0.02 | 0.5 |
Brugia malayi | Aspartyl aminopeptidase | 0.0072 | 0.2833 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1099 | 0.3417 |
Loa Loa (eye worm) | aspartyl aminopeptidase | 0.0072 | 0.2833 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1099 | 0.3417 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0036 | 0.1117 | 0.0936 |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.1617 | 0.5382 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.1099 | 0.0918 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0036 | 0.1117 | 0.0046 |
Trypanosoma brucei | trypanothione reductase | 0.0046 | 0.1617 | 0.5382 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1099 | 0.3881 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1035 | 0.3171 |
Trypanosoma cruzi | aspartyl aminopeptidase, putative | 0.0072 | 0.2833 | 1 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0034 | 0.1035 | 0.3171 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1099 | 0.0918 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.1312 | 0.4225 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0016 | 0.02 | 0.0704 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1757 | 0.5913 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1099 | 0.3881 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0118 | 0.4948 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.1757 | 0.3792 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1312 | 0.4225 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.1617 | 0.5382 |
Onchocerca volvulus | 0.0035 | 0.1099 | 0.5 | |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0072 | 0.2833 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1099 | 0.8087 |
Trypanosoma cruzi | metallo-peptidase, Clan MH, Family M20 | 0.0072 | 0.2833 | 1 |
Plasmodium vivax | M18 aspartyl aminopeptidase, putative | 0.0072 | 0.2833 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.1757 | 0.5913 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1035 | 0.3171 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.1312 | 0.4225 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1312 | 0.4225 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.1617 | 0.5382 |
Echinococcus granulosus | aspartyl aminopeptidase | 0.0072 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0106 | 0.4396 | 0.4282 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1099 | 0.146 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.1617 | 0.5382 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0034 | 0.1035 | 0.3171 |
Mycobacterium leprae | PROBABLE AMINOPEPTIDASE PEPC | 0.0072 | 0.2833 | 0.4505 |
Treponema pallidum | NADH oxidase | 0.0016 | 0.02 | 0.5 |
Brugia malayi | Inositol-1 | 0.004 | 0.1312 | 0.4632 |
Entamoeba histolytica | aminopeptidase, putative | 0.0072 | 0.2833 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.1312 | 0.7851 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.1312 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0046 | 0.1617 | 0.5382 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1099 | 0.3417 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.1757 | 0.5913 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1099 | 0.8087 |
Mycobacterium tuberculosis | Probable reductase | 0.0106 | 0.4396 | 0.4282 |
Onchocerca volvulus | 0.0035 | 0.1099 | 0.5 | |
Leishmania major | aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20 | 0.0072 | 0.2833 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1099 | 0.3417 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1099 | 0.3417 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0034 | 0.1035 | 0.3171 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.1312 | 0.1805 |
Brugia malayi | glutathione reductase | 0.0046 | 0.1617 | 0.5707 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.1617 | 0.5382 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0072 | 0.2833 | 1 |
Leishmania major | trypanothione reductase | 0.0046 | 0.1617 | 0.5382 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1099 | 0.3417 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1099 | 0.3881 |
Entamoeba histolytica | aspartyl aminopeptidase, putative | 0.0072 | 0.2833 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0106 | 0.4396 | 0.4282 |
Onchocerca volvulus | 0.0035 | 0.1099 | 0.5 | |
Loa Loa (eye worm) | glutathione reductase | 0.0046 | 0.1617 | 0.2985 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0072 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0106 | 0.4396 | 0.4282 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1099 | 0.3417 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1099 | 0.3417 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0072 | 0.2833 | 0.4272 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.1099 | 0.0918 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.1099 | 0.0918 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.1312 | 0.4225 |
Trichomonas vaginalis | Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase | 0.0072 | 0.2833 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1757 | 0.2526 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1099 | 0.8087 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.1617 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.1312 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.1312 | 0.4225 |
Echinococcus multilocularis | aspartyl aminopeptidase | 0.0072 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.1099 | 0.0918 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0118 | 0.4948 | 0.4845 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.1099 | 0.0918 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1757 | 0.2526 |
Schistosoma mansoni | aspartyl aminopeptidase (M18 family) | 0.0072 | 0.2833 | 0.4272 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.1617 | 0.1446 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1099 | 0.8087 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1099 | 0.146 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.1617 | 0.5382 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.1099 | 0.0918 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0106 | 0.4396 | 0.8565 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.1757 | 0.6201 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.1099 | 0.0918 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1099 | 0.3417 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.1312 | 0.4225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.1757 | 0.2526 |
Trichomonas vaginalis | hypothetical protein | 0.0034 | 0.1035 | 0.3171 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.1099 | 0.3417 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0046 | 0.1617 | 0.2985 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2833 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0106 | 0.4396 | 0.4282 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1099 | 0.3881 |
Trypanosoma brucei | aspartyl aminopeptidase, putative | 0.0072 | 0.2833 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1099 | 0.3417 |
Mycobacterium tuberculosis | Probable aminopeptidase PepC | 0.0072 | 0.2833 | 0.2687 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0106 | 0.4396 | 0.4282 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.1617 | 0.5707 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0118 | 0.4948 | 0.4845 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.1312 | 0.1228 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0118 | 0.4948 | 0.4845 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0034 | 0.1035 | 0.3171 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.1312 | 0.1805 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.