TDR Targets

Basic information

Technical information

TDR Targets ID: 567186
Name: (3E)-3-[(2-arsonophenyl)hydrazono]-5-hydroxy- 4-oxo-naphthalene-2,7-disulfonic acid
MW: 548.333 | Formula: C16H13AsN2O11S2
H donors: 6 H acceptors: 11 LogP: 0.44 Rotable bonds: 5
Rule of 5 violations (Lipinski): 4
SMILES: Oc1cc(cc2c1C(=O)C(=NNc1ccccc1[As](=O)(O)O)C(=C2)S(=O)(=O)O)S(=O)(=O)O
InChi: 1S/C16H13AsN2O11S2/c20-12-7-9(31(25,26)27)5-8-6-13(32(28,29)30)15(16(21)14(8)12)19-18-11-4-2-1-3-10(11)17(22,23)24/h1-7,18,20H,(H2,22,23,24)(H,25,26,27)(H,28,29,30)/b19-15-
InChiKey: OTAYPGXXYDXKDK-CYVLTUHYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3E)-3-[(2-arsonophenyl)hydrazono]-5-hydroxy-4-oxonaphthalene-2,7-disulfonic acid
(3E)-3-[(2-arsonophenyl)hydrazinylidene]-5-hydroxy-4-oxo-naphthalene-2,7-disulfonic acid
(3E)-3-[(2-arsonophenyl)hydrazono]-5-hydroxy-4-keto-naphthalene-2,7-disulfonic acid
(3E)-3-[(2-arsonophenyl)hydrazinylidene]-5-hydroxy-4-oxonaphthalene-2,7-disulfonic acid
arsenazo I

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Aspartyl aminopeptidase	0.0072	0.2833	1
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.1035	0.3171
Onchocerca volvulus		0.0035	0.1099	0.5
Echinococcus multilocularis	inositol monophosphatase 1	0.004	0.1312	0.4225
Loa Loa (eye worm)	glutathione reductase	0.0046	0.1617	0.2985
Trichomonas vaginalis	hypothetical protein	0.0034	0.1035	0.3171
Mycobacterium ulcerans	lipase LipD	0.0035	0.1099	0.8087
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.1099	0.0918
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1757	0.5913
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0034	0.1035	0.3171
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0072	0.2833	0.4272
Onchocerca volvulus		0.0035	0.1099	0.5
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0106	0.4396	0.4282
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1099	0.0918
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.1099	0.3417
Plasmodium falciparum	thioredoxin reductase	0.0046	0.1617	0.5382
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0118	0.4948	0.4845
Mycobacterium tuberculosis	Probable reductase	0.0106	0.4396	0.4282
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.1099	0.3417
Echinococcus granulosus	aspartyl aminopeptidase	0.0072	0.2833	1
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.1617	0.2985
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.1617	0.5382
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.1035	0.3171
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1757	0.2526
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1312	0.4225
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0118	0.4948	0.4845
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0036	0.1117	0.0936
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1099	0.3417
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0036	0.1117	0.0046
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0118	0.4948	1
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.004	0.1312	1
Mycobacterium ulcerans	beta-lactamase	0.0035	0.1099	0.8087
Plasmodium falciparum	glutathione reductase	0.0046	0.1617	0.5382
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0106	0.4396	0.4282
Treponema pallidum	NADH oxidase	0.0016	0.02	0.5
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.1617	0.5382
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2833	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1757	0.2526
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.02	0.0704
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.1099	0.8087
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0072	0.2833	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1099	0.146
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1757	0.3792
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.004	0.1312	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1099	0.3417
Toxoplasma gondii	ABC1 family protein	0.0035	0.1099	0.6349
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.1099	0.0918
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0106	0.4396	0.4282
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1757	0.5913
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.1035	0.3171
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0016	0.02	0.5
Brugia malayi	beta-lactamase family protein	0.0035	0.1099	0.3881
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.1099	0.3417
Plasmodium vivax	M18 aspartyl aminopeptidase, putative	0.0072	0.2833	1
Brugia malayi	beta-lactamase family protein	0.0035	0.1099	0.3881
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.1617	0.5382
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1312	0.4225
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.1099	0.146
Entamoeba histolytica	aspartyl aminopeptidase, putative	0.0072	0.2833	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2833	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.1312	0.4225
Brugia malayi	glutathione reductase	0.0046	0.1617	0.5707
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.1617	0.5382
Brugia malayi	beta-lactamase	0.0035	0.1099	0.3881
Schistosoma mansoni	aspartyl aminopeptidase (M18 family)	0.0072	0.2833	0.4272
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0034	0.1035	0.3171
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.1099	0.3881
Mycobacterium leprae	PROBABLE AMINOPEPTIDASE PEPC	0.0072	0.2833	0.4505
Onchocerca volvulus		0.0035	0.1099	0.5
Entamoeba histolytica	aminopeptidase, putative	0.0072	0.2833	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.004	0.1312	0.4225
Brugia malayi	Inositol-1	0.004	0.1312	0.4632
Leishmania major	aspartyl aminopeptidase, putative,metallo-peptidase, Clan MH, Family M20	0.0072	0.2833	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0118	0.4948	0.4845
Echinococcus granulosus	inositol monophosphatase 1	0.004	0.1312	0.4225
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0072	0.2833	1
Trypanosoma cruzi	metallo-peptidase, Clan MH, Family M20	0.0072	0.2833	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1757	0.5913
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1312	0.4225
Schistosoma mansoni	inositol monophosphatase	0.004	0.1312	0.1805
Toxoplasma gondii	thioredoxin reductase	0.0046	0.1617	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1757	0.6201
Schistosoma mansoni	inositol monophosphatase	0.004	0.1312	0.1805
Loa Loa (eye worm)	aspartyl aminopeptidase	0.0072	0.2833	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.1099	0.0918
Trichomonas vaginalis	esterase, putative	0.0035	0.1099	0.3417
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0034	0.1035	0.3171
Leishmania major	hypothetical protein, conserved	0.0035	0.1099	0.3417
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0106	0.4396	0.8565
Trypanosoma brucei	aspartyl aminopeptidase, putative	0.0072	0.2833	1
Echinococcus multilocularis	aspartyl aminopeptidase	0.0072	0.2833	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.1099	0.3417
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.1099	0.8087
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1099	0.0918
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.1099	0.3417
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.004	0.1312	0.7851
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0072	0.2833	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1757	0.5913
Mycobacterium tuberculosis	Probable aminopeptidase PepC	0.0072	0.2833	0.2687
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.004	0.1312	0.4225
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.1099	0.3417
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.1099	0.0918
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0016	0.02	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1757	0.2526
Trypanosoma brucei	trypanothione reductase	0.0046	0.1617	0.5382
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.1617	0.1446
Mycobacterium ulcerans	hypothetical protein	0.0035	0.1099	0.8087
Plasmodium falciparum	M18 aspartyl aminopeptidase	0.0072	0.2833	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0106	0.4396	0.4282
Loa Loa (eye worm)	inositol-1	0.004	0.1312	0.1228
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1099	0.3417
Trichomonas vaginalis	inositol monophosphatase, putative	0.004	0.1312	0.4225
Trypanosoma cruzi	aspartyl aminopeptidase, putative	0.0072	0.2833	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.1617	0.5382
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1099	0.3417
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.1099	0.3417
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0106	0.4396	0.4282
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.1099	0.0918
Trichomonas vaginalis	Clan MH, family M18, aspartyl aminopeptidase-like metallopeptidase	0.0072	0.2833	1
Brugia malayi	Thioredoxin reductase	0.0046	0.1617	0.5707
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.1099	0.0918
Mycobacterium tuberculosis	Conserved protein	0.0035	0.1099	0.0918
Leishmania major	trypanothione reductase	0.0046	0.1617	0.5382
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.1099	0.0918

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 6911855

Bibliographic References

No literature references available for this target.

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Detailed information for compound 567186