Detailed information for compound 567551

Basic information

Technical information
  • TDR Targets ID: 567551
  • Name: 1-nitroso-3,6-disulfonate
  • MW: 379.274 | Formula: C10H7NNa2O8S2
  • H donors: 1 H acceptors: 8 LogP: 0.07 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=Nc1c2ccc(cc2cc(c1O)S(=O)(=O)[O-])S(=O)(=O)[O-].[NaH+].[NaH+]
  • InChi: 1S/C10H7NO8S2.2Na/c12-10-8(21(17,18)19)4-5-3-6(20(14,15)16)1-2-7(5)9(10)11-13;;/h1-4,12H,(H,14,15,16)(H,17,18,19);;/q;2*+1/p-2
  • InChiKey: DMKMTGULLYISBH-UHFFFAOYSA-L  


Substructure search Similarity search

Network

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Synonyms

  • 1-Nitroso-2-naphthol-3,6-disulfonic acid disodium salt
  • 140212-78-8
  • 2,7-NAPHTHALENEDISULFONIC ACID, 3-HYDROXY-4-NITROSO-, DISODIUM SALT
  • 2-Hydroxy-3-nitroso-2,7-naphthalenedisulfonic acid disodium salt
  • 3-Hydroxy-4-nitroso-2,7-naphthalenedisulfonic acid disodium salt
  • 525-05-3
  • 73950_FLUKA
  • AI3-22012
  • Disodium 1-nitroso-2-naphthol-3,6-disulfonate
  • disodium 3-hydroxy-4-nitroso-naphthalene-2,7-disulfonate
  • disodium 3-hydroxy-4-nitrosonaphthalene-2,7-disulfonate
  • Disodium 3-hydroxy-4-nitrosonaphthalene-2,7-disulphonate
  • EINECS 208-369-1
  • Nitroso R
  • Nitroso-R salt
  • NSC 5044
  • ST5307847

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0147 0.4779 0.4398
Plasmodium vivax glutathione reductase, putative 0.0046 0.068 0.9904
Onchocerca volvulus 0.0147 0.4779 0.2999
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.3547 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0046 0.0686 0.1247
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2542 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0233 0.0424
Giardia lamblia Kinase, PLK 0.0092 0.2542 0.5
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0276 1 1
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0098 0.2794 0.2794
Echinococcus multilocularis CREB binding protein 0.0067 0.1543 0.2804
Schistosoma mansoni hypothetical protein 0.0165 0.5504 0.5504
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.0686 0.0035
Brugia malayi hypothetical protein 0.0147 0.4779 0.4655
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.2542 0.462
Onchocerca volvulus 0.0276 1 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.068 0.9904
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Loa Loa (eye worm) CBP-B 0.0068 0.1578 0.0964
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.068 0.1235
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0046 0.0686 0.0035
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.068 0.1916
Schistosoma mansoni tyrosinase precursor 0.0276 1 1
Brugia malayi Methionine aminopeptidase protein type I 0.0046 0.0686 0.0464
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0276 1 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.3072 0.866
Schistosoma mansoni kinase 0.0047 0.0708 0.0708
Loa Loa (eye worm) tyrosinase 1 0.0276 1 1
Mycobacterium ulcerans methionine aminopeptidase 0.0029 0 0.5
Brugia malayi Thioredoxin reductase 0.0046 0.068 0.0457
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.3547 1
Schistosoma mansoni tyrosinase precursor 0.0276 1 1
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0046 0.0686 0.0035
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.3072 0.866
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.068 0.9904
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0046 0.0686 0.0035
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.2542 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0046 0.0686 0.086
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0046 0.0686 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.3072 0.866
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0046 0.0686 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.2542 0.1999
Brugia malayi TAZ zinc finger family protein 0.0098 0.2794 0.2622
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.3547 1
Treponema pallidum methionine aminopeptidase (map) 0.0029 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0276 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0233 0.0233
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.3072 0.866
Trypanosoma brucei methionine aminopeptidase, putative 0.0046 0.0686 0.0035
Echinococcus granulosus CREB binding protein 0.0061 0.1268 0.1964
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.0686 0.0035
Echinococcus granulosus CREB binding protein 0.0098 0.2794 0.486
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0233 0.0233
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0029 0 0.5
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0276 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Schistosoma mansoni CREB-binding protein 2 0.0098 0.2794 0.2794
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.3072 0.866
Onchocerca volvulus 0.0276 1 1
Onchocerca volvulus 0.0276 1 1
Loa Loa (eye worm) hypothetical protein 0.0276 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.2542 0.2542
Loa Loa (eye worm) methionine aminopeptidase type I 0.0046 0.0686 0.0007
Brugia malayi Common central domain of tyrosinase family protein 0.0276 1 1
Plasmodium falciparum glutathione reductase 0.0046 0.068 0.9904
Loa Loa (eye worm) ShTK domain-containing protein 0.0276 1 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.2542 0.4382
Loa Loa (eye worm) ShTK domain-containing protein 0.0276 1 1
Trypanosoma brucei polo-like protein kinase 0.0092 0.2542 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.2542 0.2364
Loa Loa (eye worm) hypothetical protein 0.0046 0.0682 0.0002
Brugia malayi glutathione reductase 0.0046 0.068 0.0457
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.3072 0.866
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0276 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.3547 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.2542 1
Echinococcus multilocularis geminin 0.0165 0.5504 1
Chlamydia trachomatis methionine aminopeptidase 0.0029 0 0.5
Toxoplasma gondii methionine aminopeptidase 0.0046 0.0686 1
Schistosoma mansoni hypothetical protein 0.0165 0.5504 0.5504
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.3072 0.866
Onchocerca volvulus 0.0276 1 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.068 0.0847
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.2542 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0092 0.2542 1
Echinococcus granulosus geminin 0.0165 0.5504 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.068 0.9904
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0029 0 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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