Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0046 | 0.0686 | 0.0035 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.2542 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0046 | 0.0686 | 0.086 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0046 | 0.0686 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0105 | 0.3072 | 0.866 |
Schistosoma mansoni | kinase | 0.0047 | 0.0708 | 0.0708 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0105 | 0.3072 | 0.866 |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0029 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0276 | 1 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0046 | 0.068 | 0.0457 |
Schistosoma mansoni | tyrosinase precursor | 0.0276 | 1 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0117 | 0.3547 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0105 | 0.3072 | 0.866 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0046 | 0.0686 | 0.0035 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0046 | 0.068 | 0.9904 |
Loa Loa (eye worm) | CBP-B | 0.0068 | 0.1578 | 0.0964 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0046 | 0.0686 | 0.0035 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0046 | 0.068 | 0.1235 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0046 | 0.068 | 0.1916 |
Schistosoma mansoni | tyrosinase precursor | 0.0276 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0276 | 1 | 1 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0046 | 0.0686 | 0.0464 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0117 | 0.3547 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0046 | 0.068 | 0.9904 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Onchocerca volvulus | 0.0147 | 0.4779 | 0.2999 | |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.4779 | 0.4398 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.2542 | 0.5 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0046 | 0.0686 | 0.1247 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.2542 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0233 | 0.0424 |
Schistosoma mansoni | CREB-binding protein 1 (SmCBP1) | 0.0098 | 0.2794 | 0.2794 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0276 | 1 | 1 |
Echinococcus multilocularis | CREB binding protein | 0.0067 | 0.1543 | 0.2804 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5504 | 0.5504 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0092 | 0.2542 | 0.462 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0046 | 0.0686 | 0.0035 |
Brugia malayi | hypothetical protein | 0.0147 | 0.4779 | 0.4655 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Plasmodium falciparum | thioredoxin reductase | 0.0046 | 0.068 | 0.9904 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0046 | 0.0686 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5504 | 0.5504 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0105 | 0.3072 | 0.866 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0046 | 0.068 | 0.0847 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.2542 | 1 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0029 | 0 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0046 | 0.068 | 0.9904 |
Echinococcus granulosus | geminin | 0.0165 | 0.5504 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0682 | 0.0002 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0092 | 0.2542 | 0.2364 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.2542 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0105 | 0.3072 | 0.866 |
Brugia malayi | glutathione reductase | 0.0046 | 0.068 | 0.0457 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0117 | 0.3547 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0276 | 1 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.2542 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5504 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0105 | 0.3072 | 0.866 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.2542 | 0.2542 |
Onchocerca volvulus | 0.0276 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0046 | 0.0686 | 0.0007 |
Plasmodium falciparum | glutathione reductase | 0.0046 | 0.068 | 0.9904 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0276 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0092 | 0.2542 | 0.4382 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0276 | 1 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0092 | 0.2542 | 0.1999 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0046 | 0.0686 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0117 | 0.3547 | 1 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0029 | 0 | 0.5 |
Brugia malayi | TAZ zinc finger family protein | 0.0098 | 0.2794 | 0.2622 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0105 | 0.3072 | 0.866 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0233 | 0.0233 |
Echinococcus granulosus | CREB binding protein | 0.0061 | 0.1268 | 0.1964 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0046 | 0.0686 | 0.0035 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0046 | 0.0686 | 0.0035 |
Echinococcus granulosus | CREB binding protein | 0.0098 | 0.2794 | 0.486 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0233 | 0.0233 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0276 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.2542 | 1 |
Schistosoma mansoni | CREB-binding protein 2 | 0.0098 | 0.2794 | 0.2794 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0029 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.