Detailed information for compound 569257

Basic information

Technical information
  • TDR Targets ID: 569257
  • Name: 1-(5-tetradecoxy-2-furyl)ethanone
  • MW: 322.482 | Formula: C20H34O3
  • H donors: 0 H acceptors: 1 LogP: 7.98 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCCCCCCCOc1ccc(o1)C(=O)C
  • InChi: 1S/C20H34O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-22-20-16-15-19(23-20)18(2)21/h15-16H,3-14,17H2,1-2H3
  • InChiKey: MMOTUYBUAZJWRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(5-tetradecoxyfuran-2-yl)ethanone
  • 1-(5-myristyloxy-2-furyl)ethanone
  • RMI 15731
  • 54857-96-4
  • RMI-15731
  • 1-(5-(Tetradecyloxy)-2-furanyl)ethanone
  • NSC 317936
  • Rmi 15,731
  • NSC317936
  • AIDS-195561
  • AIDS195561

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Trypanosoma cruzi major cysteine proteinase, putative 0.0111 0.4741 0.7656
Schistosoma mansoni hypothetical protein 0.0017 0.0234 0.037
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.4334 0.5131
Loa Loa (eye worm) cysteine protease 0.0037 0.1191 0.1191
Brugia malayi Cathepsin L-like precursor 0.0037 0.1191 0.1191
Onchocerca volvulus 0.0037 0.1191 0.103
Schistosoma mansoni troponin I 0.0116 0.4976 0.788
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0603 0.0603
Onchocerca volvulus Cathepsin L homolog 0.0037 0.1191 0.103
Brugia malayi Cathepsin L-like precursor 0.0025 0.0603 0.0603
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Echinococcus multilocularis cysteine protease 0.0037 0.1191 0.1198
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0234 0.0234
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.1191 0.2154
Schistosoma mansoni hypothetical protein 0.0017 0.0234 0.037
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.1191 0.1198
Plasmodium vivax vivapain-2 0.0037 0.1191 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0234 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.4334 0.4334
Loa Loa (eye worm) hypothetical protein 0.0037 0.1187 0.1187
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.1191 0.2154
Leishmania major cathepsin L-like protease 0.0142 0.6192 1
Echinococcus multilocularis troponin i 0.0116 0.4976 0.5935
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.1191 0.1198
Loa Loa (eye worm) hypothetical protein 0.0069 0.2712 0.2712
Echinococcus granulosus oncosphere protein Tso22e 0.0144 0.6315 0.761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.1191 0.2154
Plasmodium vivax unspecified product 0.0019 0.0328 0.2757
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.4334 0.6532
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Schistosoma mansoni hypothetical protein 0.0017 0.0234 0.037
Schistosoma mansoni hypothetical protein 0.0037 0.1187 0.188
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.4334 0.4334
Plasmodium vivax vivapain-2 0.0037 0.1191 1
Onchocerca volvulus 0.0037 0.1191 0.103
Giardia lamblia Kinase, PLK 0.0103 0.4334 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.1187 0.1187
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0328 0.0328
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.1191 0.1191
Loa Loa (eye worm) hypothetical protein 0.0221 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.2009 0.2009
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.4334 0.5131
Trypanosoma brucei polo-like protein kinase 0.0103 0.4334 0.6831
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0069 0.2712 0.3693
Loa Loa (eye worm) hypothetical protein 0.0116 0.4976 0.4976
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Brugia malayi Cathepsin L-like precursor 0.0037 0.1191 0.1191
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.1191 0.2154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Toxoplasma gondii cathepsin CPL 0.0037 0.1191 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Schistosoma mansoni troponin t invertebrate 0.0144 0.6315 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0184 0.8224 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.1191 1
Brugia malayi cathepsin L-like precursor 0.0025 0.0603 0.0603
Loa Loa (eye worm) troponin T 0.0069 0.2712 0.2712
Echinococcus granulosus troponin i 0.0116 0.4976 0.5935
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.1191 0.1191
Brugia malayi Troponin family protein 0.0116 0.4976 0.4976
Schistosoma mansoni kinase 0.0052 0.1913 0.303
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0603 0.0955
Plasmodium vivax vivapain-1 0.0019 0.0328 0.2757
Onchocerca volvulus 0.0037 0.1191 0.103
Brugia malayi hypothetical protein 0.0069 0.2712 0.2712
Brugia malayi Cathepsin L-like precursor 0.0037 0.1191 0.1191
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0328 0.052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Echinococcus granulosus cysteine protease 0.0019 0.0328 0.0119
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.1191 0.1191
Onchocerca volvulus Troponin I homolog 0.0116 0.4976 0.7657
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.1191 0.1198
Echinococcus multilocularis oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 0.0144 0.6315 0.761
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0328 0.053
Brugia malayi Cathepsin L-like precursor 0.0037 0.1191 0.1191
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.4334 0.6999
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Onchocerca volvulus 0.0037 0.1191 0.103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Echinococcus granulosus cathepsin l1 0.0025 0.0603 0.0462
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.1191 1
Onchocerca volvulus Troponin T, skeletal muscle homolog 0.0144 0.6315 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.4334 0.6999
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0603 0.0603
Loa Loa (eye worm) hypothetical protein 0.0025 0.0603 0.0603
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.4334 0.6863
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Trypanosoma cruzi cysteine protease, putative 0.0019 0.0328 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.1191 1
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0328 0.0119
Brugia malayi Troponin T 0.0069 0.2712 0.2712
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.4334 0.6284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Schistosoma mansoni hypothetical protein 0.0017 0.0234 0.037
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Leishmania major cathepsin L-like protease 0.0142 0.6192 1
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0328 0.053
Echinococcus multilocularis cysteine protease 0.0037 0.1191 0.1198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.4334 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.1191 0.1886
Loa Loa (eye worm) fibroinase 0.0037 0.1191 0.1191
Brugia malayi Cathepsin L-like precursor 0.0037 0.1191 0.1191
Loa Loa (eye worm) hypothetical protein 0.0025 0.0603 0.0603
Brugia malayi Troponin I 0.0116 0.4976 0.4976
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Loa Loa (eye worm) hypothetical protein 0.0037 0.1191 0.1191
Entamoeba histolytica cysteine protease, putative 0.0037 0.1191 0.2154
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.1191 0.1198
Trypanosoma cruzi cruzipain precursor, putative 0.0142 0.6192 1
Loa Loa (eye worm) troponin 0.0069 0.2712 0.2712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0328 0.052
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0328 0.0328
Echinococcus granulosus cathepsin l1 0.0037 0.1191 0.1198
Plasmodium vivax vivapain-3 0.0019 0.0328 0.2757
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Onchocerca volvulus Cathepsin L homolog 0.0037 0.1191 0.103
Brugia malayi Cathepsin L-like precursor 0.0025 0.0603 0.0603
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1848 0.3795
Brugia malayi Troponin T 0.0069 0.2712 0.2712
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Echinococcus granulosus cathepsin L 0.0019 0.0328 0.0119
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0184 0.8224 1
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0603 0.0685
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Loa Loa (eye worm) ctsf protein 0.0037 0.1191 0.1191
Onchocerca volvulus Cathepsin F homolog 0.0037 0.1191 0.103
Loa Loa (eye worm) hypothetical protein 0.0017 0.0234 0.0234
Onchocerca volvulus 0.0037 0.1191 0.103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.6192 1
Brugia malayi Troponin T 0.0069 0.2712 0.2712
Schistosoma mansoni troponin I 0.0116 0.4976 0.788
Loa Loa (eye worm) troponin I 0.0116 0.4976 0.4976
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.0328 0.053
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Schistosoma mansoni hypothetical protein 0.0116 0.4976 0.788
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.1191 0.1924
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0603 0.0685
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0328 0.052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.4334 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.1191 0.2154
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.1191 0.1198
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0328 0.053
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0129 0.5603 0.905
Loa Loa (eye worm) hypothetical protein 0.0116 0.4976 0.4976
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0142 0.6192 1
Onchocerca volvulus 0.0037 0.1191 0.103
Schistosoma mansoni troponin I 0.0116 0.4976 0.788
Schistosoma mansoni troponin I 0.0116 0.4976 0.788
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.1191 0.2154
Leishmania major cathepsin L-like protease 0.0142 0.6192 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.2009 0.2009
Onchocerca volvulus 0.0037 0.1191 0.103
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.1191 0.1198
Echinococcus multilocularis cathepsin L 0.0019 0.0328 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.1848 0.3795
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0234 0.0234
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.1191 0.1886
Brugia malayi Cathepsin L-like precursor 0.0037 0.1191 0.1191
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0603 0.0685
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.6192 1
Trypanosoma cruzi cysteine peptidase, putative 0.0142 0.6192 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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