Detailed view for OVOC4756

Basic information

TDR Targets ID: 987412
Onchocerca volvulus, Troponin T, skeletal muscle homolog
Source Database / ID:  Wormbase Parasite  

pI: 10.1701 | Length (AA): 61 | MW (Da): 7018 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00992  

Gene Ontology

Mouse over links to read term descriptions.
GO:0006937   regulation of muscle contraction  
GO:0005861   troponin complex  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1176 1481 4u1d (C) 20 362 7.00 0 0.02 0.157726 -0.66
1178 1411 4tql (A) 19 238 18.00 0 0.32 0.289379 -1.54
1240 1446 3na7 (A) 6 191 24.00 0.92 0.73 0.389124 -0.72
1254 1326 5xis (A) 111 184 29.00 0 0.02 0.546449 -3.69
1257 1331 5wst (A) 866 928 48.00 0.11 0.17 0.348654 -1.47

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129858)

Species Accession Gene Product
Brugia malayi Bm1_53905   Troponin T
Brugia malayi Bm1_05160   Troponin T
Brugia malayi Bm1_09610   Troponin T
Brugia malayi Bm1_38610   hypothetical protein
Caenorhabditis elegans CELE_F53A9.10   Protein TNT-2, isoform B
Caenorhabditis elegans CELE_C14F5.3   Protein TNT-3, isoform C
Caenorhabditis elegans CELE_T22E5.5   Protein MUP-2
Caenorhabditis elegans CELE_T08B1.2   Protein TNT-4, isoform B
Drosophila melanogaster Dmel_CG7107   upheld
Echinococcus granulosus EgrG_000962000   oncosphere protein Tso22e
Echinococcus multilocularis EmuJ_000962000   oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22
Homo sapiens ENSG00000118194   troponin T type 2 (cardiac)
Homo sapiens ENSG00000130595   troponin T type 3 (skeletal, fast)
Loa Loa (eye worm) LOAG_06631   troponin
Loa Loa (eye worm) LOAG_09626   hypothetical protein
Loa Loa (eye worm) LOAG_10094   troponin T
Mus musculus ENSMUSG00000061723   troponin T3, skeletal, fast
Mus musculus ENSMUSG00000026414   troponin T2, cardiac
Onchocerca volvulus OVOC4756   Troponin T, skeletal muscle homolog
Onchocerca volvulus OVOC8062   Troponin T, skeletal muscle homolog
Schistosoma japonicum Sjp_0303490   Troponin T, skeletal muscle, putative
Schistosoma mansoni Smp_179810   troponin t invertebrate
Schmidtea mediterranea mk4.000275.04   Troponin T, skeletal muscle

Essentiality

OVOC4756 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T22E5.5 Caenorhabditis elegans slow growth wormbase
CELE_T22E5.5 Caenorhabditis elegans sterile wormbase
CELE_F53A9.10 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens troponin T type 2 (cardiac) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0136 0.3132 0.6936
0.0135 0.6456 1
0.0145 0.6352 1
0.0145 0.6352 1
0.0142 0.6416 1
0.0151 0.3164 0.7253
0.0136 0.6456 1
0.016 0.2926 0.2867
0.0144 0.2648 0.2641
0.0137 0.6456 1
0.015 0.3161 0.7268
0.0143 0.4435 0.5389
0.0134 0.6456 1
0.0136 0.2883 0.2883
0.0132 0.295 0.6162
0.0129 0.6456 1
0.0151 0.8933 1
0.016 0.6226 1
0.0128 0.3321 0.4782
0.016 0.3149 0.4194
0.0131 0.4133 1
0.016 0.2992 0.5227
0.0137 0.2781 0.3928
0.0138 0.4272 1
0.014 0.6456 1
0.0145 0.6352 1
0.0142 0.6433 0.7952
0.0133 0.3137 0.6915
0.0146 0.6269 1
0.0132 0.6456 1
0.0154 0.271 0.3433
0.0136 0.2882 0.2882
0.0155 0.2859 0.4439
0.0146 0.4493 0.514
0.0141 0.3132 0.7241
0.0133 0.6456 1
0.016 0.5214 1
0.0136 0.2646 0.3438
0.016 0.321 0.4255
0.016 0.4214 1
0.016 0.5826 0.7877
0.0143 0.4363 0.538
0.0138 0.4272 1
0.0144 0.4493 1
0.0145 0.6352 1
0.0135 0.553 0.553
0.0137 1 1
0.0138 1 1
0.0144 0.6451 1
0.016 0.3138 0.7241
0.0151 0.6456 1
0.0131 0.6456 1
0.0145 0.6352 1
0.014 0.3129 0.7221
0.013 0.3138 0.6302
0.0145 0.6352 1
0.0147 0.3076 0.4194
0.016 0.3129 0.426
0.0145 0.3118 0.9775
0.0154 0.6286 1
0.016 0.4313 0.4287
0.0128 0.4493 0.4966
0.0154 0.2603 0.3564
0.0144 0.6315 1
0.0131 0.3456 1
0.0142 0.6425 1
0.0129 0.6456 1
0.0135 0.6226 1
0.0135 0.6456 1
0.0136 0.4022 1
0.0135 0.6456 1
0.0146 0.3491 0.4233
0.016 0.2707 0.5382
0.016 0.6456 1
0.0141 0.2585 0.3514
0.0134 0.3562 1
0.0129 0.4582 1
0.0115 0.3149 0.4194
0.0129 0.4293 1
0.0145 0.6376 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier OVOC4756 (Onchocerca volvulus), Troponin T, skeletal muscle homolog
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