Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide | 0.014 | 0.0833 | 0.0824 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0366 | 0.3118 | 1 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0358 | 0.3035 | 0.3027 |
Echinococcus granulosus | neuropeptide s receptor | 0.0449 | 0.3957 | 0.3951 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.0833 | 0.0824 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1096 | 0.1087 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.01 | 0.0428 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.014 | 0.0833 | 0.0824 |
Echinococcus granulosus | geminin | 0.0165 | 0.1085 | 0.1075 |
Echinococcus multilocularis | Endonuclease G | 0.01 | 0.0428 | 0.0418 |
Onchocerca volvulus | 0.0366 | 0.3118 | 1 | |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1096 | 0.1096 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.001 | 0.001 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1085 | 0.1085 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1096 | 0.1096 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0366 | 0.3118 | 1 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0366 | 0.3118 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.001 | 0.001 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0166 | 0.1096 | 0.1087 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0788 | 0.7374 | 0.7371 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0128 | 0.0714 | 0.0704 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0128 | 0.0714 | 0.0704 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0113 | 0.0562 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.1048 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1096 | 0.1087 |
Schistosoma mansoni | hypothetical protein | 0.0358 | 0.3035 | 0.3035 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Schistosoma mansoni | lipoxygenase | 0.008 | 0.0232 | 0.0232 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0449 | 0.3957 | 0.3951 |
Echinococcus granulosus | ectonucleotide | 0.014 | 0.0833 | 0.0824 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.1048 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0128 | 0.0714 | 0.0704 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.1048 | 1 | 1 |
Schistosoma mansoni | endonuclease related | 0.01 | 0.0428 | 0.0428 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1085 | 0.1085 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0366 | 0.3118 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0449 | 0.3957 | 0.3951 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0366 | 0.3118 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 0.0562 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.1096 | 0.1087 |
Brugia malayi | Protein kinase domain containing protein | 0.0071 | 0.0137 | 0.0127 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0366 | 0.3118 | 1 |
Onchocerca volvulus | 0.0358 | 0.3035 | 0.9586 | |
Schistosoma mansoni | tyrosine kinase | 0.0058 | 0.001 | 0.001 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0366 | 0.3118 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0128 | 0.0714 | 0.0704 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1096 | 0.1096 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Echinococcus granulosus | Endonuclease G | 0.01 | 0.0428 | 0.0418 |
Brugia malayi | endonuclease G, mitochondrial precursor | 0.01 | 0.0428 | 0.0418 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0128 | 0.0714 | 0.0704 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.058 | 0.058 |
Brugia malayi | Thrombospondin type 1 domain containing protein | 0.0358 | 0.3035 | 0.3027 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0113 | 0.0562 | 1 |
Echinococcus multilocularis | geminin | 0.0165 | 0.1085 | 0.1075 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0366 | 0.3118 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0366 | 0.3118 | 0.3111 |
Echinococcus multilocularis | insulin receptor | 0.0128 | 0.0714 | 0.0704 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.1048 | 1 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0166 | 0.1096 | 0.1096 |
Leishmania major | hypothetical protein, conserved | 0.0113 | 0.0562 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.014 | 0.0833 | 0.0824 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0253 | 0.1979 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0127 | 0.0117 |
Brugia malayi | Low molecular weight phosphotyrosine protein phosphatase containing protein | 0.0366 | 0.3118 | 0.3111 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0366 | 0.3118 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0449 | 0.3957 | 0.3951 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.058 | 0.057 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0366 | 0.3118 | 0.5 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.058 | 0.057 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.0714 | 0.0714 |
Schistosoma mansoni | tyrosine kinase | 0.0128 | 0.0714 | 0.0714 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0166 | 0.1096 | 0.1087 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.