Detailed information for compound 574899

Basic information

Technical information
  • TDR Targets ID: 574899
  • Name: 9-[(2R,4S,5S)-4-chloro-5-(chloromethyl)tetrah ydrofuran-2-yl]purin-6-amine
  • MW: 288.133 | Formula: C10H11Cl2N5O
  • H donors: 1 H acceptors: 3 LogP: 1.07 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClC[C@@H]1O[C@H](C[C@@H]1Cl)n1cnc2c1ncnc2N
  • InChi: 1S/C10H11Cl2N5O/c11-2-6-5(12)1-7(18-6)17-4-16-8-9(13)14-3-15-10(8)17/h3-7H,1-2H2,(H2,13,14,15)/t5-,6-,7+/m0/s1
  • InChiKey: PJGDEDUVJWPDNT-LYFYHCNISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[(2R,4S,5S)-4-chloro-5-(chloromethyl)-2-tetrahydrofuranyl]-6-purinamine
  • 9-[(2R,4S,5S)-4-chloro-5-(chloromethyl)oxolan-2-yl]purin-6-amine
  • [9-[(2R,4S,5S)-4-chloro-5-(chloromethyl)tetrahydrofuran-2-yl]purin-6-yl]amine
  • DTA 35
  • 63162-55-0
  • 9H-Purin-6-amine, 9-(4-chloro-5-(chloromethyl)tetrahydro-2-furanyl)-, (2R-(2alpha,4alpha,5alpha))-
  • Dta-35
  • 9-(3',5'-Dichloro-2',3',5'-trideoxy-beta-D-threo-pentafuranosyl)adenine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0062 0.0291
Brugia malayi Cytochrome P450 family protein 0.0026 0.0063 0.0552
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0062 0.0062
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.1143 0.5385
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0241 0.211
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0062 0.0062
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0062 0.0062
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0062 0.0291
Leishmania major GTP-binding protein, putative 0.0021 0.0022 0.0195
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0264 0.5572
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0062 0.0062
Leishmania major cytochrome p450-like protein 0.0026 0.0063 0.0552
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0676 0.5912
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0062 0.0062
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0062 0.0291
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0053 0.0264 0.231
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0063 0.0552
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis GPCR, family 2 0.005 0.0241 0.0241
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0078 0.0683
Echinococcus granulosus GPCR family 2 0.005 0.0241 0.0241
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0299 0.2123 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0062 0.0062
Schistosoma mansoni biogenic amine receptor 0.0026 0.0062 0.0291
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0062 0.0062
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0379 0.2727 0.2681
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Onchocerca volvulus 0.0169 0.1143 1
Brugia malayi Cytochrome P450 family protein 0.0055 0.0281 0.2461
Echinococcus multilocularis musashi 0.0032 0.0105 0.0105
Schistosoma mansoni intermediate filament proteins 0.0032 0.0105 0.0496
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0062 0.0062
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.1143 1
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0062 0.0291
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0105 0.092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0055 0.0478
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0053 0.0264 0.231
Brugia malayi RNA, U transporter 1 0.008 0.0468 0.4092
Echinococcus granulosus g protein coupled receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0183 0.3857
Schistosoma mansoni hypothetical protein 0.0026 0.0062 0.0291
Brugia malayi RE15519p 0.0026 0.0062 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni neuropeptide receptor 0.0026 0.0062 0.0291
Brugia malayi intermediate filament protein 0.0032 0.0105 0.092
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0062 0.0062
Echinococcus granulosus intermediate filament protein 0.0032 0.0105 0.0105
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0195
Plasmodium falciparum importin beta, putative 0.0028 0.0078 0.0498
Onchocerca volvulus 0.0032 0.0105 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0183 0.3857
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0105 0.0496
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.2123 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0062 0.0291
Brugia malayi G protein-coupled receptor 0.0026 0.0062 0.0541
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0062 0.0062
Schistosoma mansoni biogenic amine receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0062 0.0062
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0062 0.0062
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis geminin 0.0166 0.112 0.112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0183 0.3857
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0038 0.0804
Loa Loa (eye worm) phosphatidylinositol 3 0.0053 0.0264 0.1244
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0022 0.0032 0.0278
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0169 0.1143 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0133 0.2812
Loa Loa (eye worm) thymidylate synthase 0.0169 0.1143 0.5385
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0062 0.0062
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus granulosus sex peptide receptor 0.0026 0.0062 0.0062
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0062 0.0291
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0053 0.0264 0.231
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0062 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1708
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1708
Schistosoma mansoni opsin-like receptor 0.0026 0.0062 0.0291
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0169 0.1143 1
Brugia malayi neuropeptide F receptor 0.0026 0.0062 0.0541
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0053 0.0264 0.1244
Echinococcus granulosus tumor protein p63 0.034 0.2431 0.2431
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0062 0.0541
Echinococcus granulosus importin subunit beta 1 0.0028 0.0078 0.0078
Schistosoma mansoni adenoreceptor 0.0026 0.0062 0.0291
Brugia malayi AKH receptor 0.0026 0.0062 0.0541
Echinococcus granulosus lamin 0.0032 0.0105 0.0105
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0102 0.2148
Brugia malayi thymidylate synthase 0.0169 0.1143 1
Schistosoma mansoni amine GPCR 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni hypothetical protein 0.005 0.0241 0.1136
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0062 0.0291
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0062 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0062 0.0291
Echinococcus granulosus serotonin receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0062 0.0291
Plasmodium vivax importin-beta 2, putative 0.0028 0.0078 0.0498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0125 0.2631
Schistosoma mansoni hypothetical protein 0.005 0.0241 0.1136
Brugia malayi Serotonin receptor 0.0026 0.0062 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0206 0.4346
Schistosoma mansoni hypothetical protein 0.0026 0.0062 0.0291
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.1342 1 1
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0062 0.0291
Schistosoma mansoni hypothetical protein 0.005 0.0241 0.1136
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0053 0.0264 0.0264
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0241 0.0241
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0062 0.0291
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.105 0.9188
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0281 0.1325
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0062 0.0291
Mycobacterium ulcerans thymidylate synthase 0.0169 0.1143 0.1087
Brugia malayi Latrophilin receptor protein 2 0.005 0.0241 0.211
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0062 0.0062
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0169 0.1143 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0062 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0062 0.0062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.105 0.4948
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0062 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0062 0.0541
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0379 0.2727 1
Schistosoma mansoni opsin-like receptor 0.0026 0.0062 0.0291
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0062 0.0291
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.008 0.0474 0.4146
Schistosoma mansoni amine GPCR 0.0026 0.0062 0.0291
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0062 0.0062
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0063 0.0552
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0062 0.0062
Schistosoma mansoni opsin-like receptor 0.0026 0.0062 0.0291
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0062 0.0541
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0022 0.0195
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0062 0.0291
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0169 0.1143 0.0703
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Brugia malayi neuropeptide F receptor 0.0026 0.0062 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Schistosoma mansoni hypothetical protein 0.0166 0.112 0.5274
Echinococcus multilocularis snurportin 1 0.0299 0.2123 0.2123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus granulosus fmrfamide receptor 0.0026 0.0062 0.0062
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0242 0.114
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0062 0.0062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0062 0.0291
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0062 0.0541
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0062 0.0062
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0042 0.0183 0.1602
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0169 0.1143 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.033 0.1555
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0053 0.0264 0.231
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0062 0.0062
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0062 0.0291
Schistosoma mansoni amine GPCR 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni hypothetical protein 0.0166 0.112 0.5274
Echinococcus granulosus g protein coupled receptor 0.0026 0.0062 0.0062
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0062 0.0541
Schistosoma mansoni neuropeptide receptor 0.0026 0.0062 0.0291
Echinococcus granulosus lamin dm0 0.0032 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0062 0.0291
Echinococcus granulosus geminin 0.0166 0.112 0.112
Schistosoma mansoni tar DNA-binding protein 0.0061 0.033 0.1555
Echinococcus multilocularis serotonin receptor 0.0026 0.0062 0.0062
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0241 0.0241
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0062 0.0062
Echinococcus multilocularis tumor protein p63 0.034 0.2431 0.2431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1715
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0053 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis lamin dm0 0.0032 0.0105 0.0105
Brugia malayi RNA binding protein 0.0061 0.033 0.2887
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0053 0.0264 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.033 0.1555
Brugia malayi Cytochrome P450 family protein 0.0026 0.0063 0.0552
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Brugia malayi Melatonin receptor type 1A 0.0026 0.0062 0.0541
Brugia malayi Dopamine receptor protein 2 0.0026 0.0062 0.0541
Brugia malayi Dopamine receptor 0.0026 0.0062 0.0541
Schistosoma mansoni ran 0.0021 0.0022 0.0105
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0104 0.2198
Schistosoma mansoni histamine h1 receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0063 0.0297
Schistosoma mansoni tar DNA-binding protein 0.0061 0.033 0.1555
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0062 0.0291
Brugia malayi Serotonin receptor 0.0026 0.0062 0.0541
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0102 0.2148
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0062 0.0062
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0062 0.0062
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0169 0.1143 1
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0105 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0104 0.2198
Echinococcus multilocularis thymidylate synthase 0.0169 0.1143 0.1143
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0053 0.0264 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0063 0.0297
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0032 0.0105 0.0496
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0062 0.0062
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0053 0.0264 0.231
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0053 0.0264 0.231
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0062 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0195
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0038 0.0333
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis serotonin receptor 0.0026 0.0062 0.0062
Schistosoma mansoni hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0062 0.0291
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1708
Echinococcus multilocularis somatostatin receptor 0.0026 0.0062 0.0062
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Schistosoma mansoni importin beta-1 0.0028 0.0078 0.0368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Entamoeba histolytica hypothetical protein 0.0023 0.0038 0.0655
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis sex peptide receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0474 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0241 0.0241
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0241 0.0241
Brugia malayi sulfakinin receptor protein 0.0026 0.0062 0.0541
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.105 0.9188
Echinococcus granulosus g protein coupled receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0264 0.5572
Schistosoma mansoni tar DNA-binding protein 0.0061 0.033 0.1555
Brugia malayi larval opioid receptor 0.0026 0.0062 0.0541
Toxoplasma gondii target of rapamycin (TOR), putative 0.0039 0.0162 0.1249
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0078 0.0078
Schistosoma mansoni lamin 0.0032 0.0105 0.0496
Trichomonas vaginalis ran, putative 0.0021 0.0022 0.047
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0062 0.0062
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0183 0.3857
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0062 0.0062
Echinococcus granulosus somatostatin receptor 0.0026 0.0062 0.0062
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0062 0.0541
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0078 0.0683
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1715
Loa Loa (eye worm) hypothetical protein 0.005 0.0241 0.1136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0038 0.0804
Loa Loa (eye worm) hypothetical protein 0.0031 0.0101 0.0475
Brugia malayi Importin beta-1 subunit 0.0028 0.0078 0.0683
Trypanosoma cruzi target of rapamycin kinase 3 0.0042 0.0183 0.1602
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0183 0.3857
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0062 0.0062
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0241 0.1136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni tar DNA-binding protein 0.0061 0.033 0.1555
Onchocerca volvulus 0.005 0.0242 0.1666
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0062 0.0062
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0062 0.0062
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0062 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Echinococcus granulosus thymidylate synthase 0.0169 0.1143 0.1143
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0157 0.105 0.4948
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0062 0.0062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0104 0.2198
Echinococcus granulosus orexin receptor type 2 0.0026 0.0062 0.0062
Echinococcus granulosus neuropeptide receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis tar DNA binding protein 0.0061 0.033 0.033
Brugia malayi TAR-binding protein 0.0061 0.033 0.2887
Leishmania major importin beta-1 subunit, putative 0.0023 0.0038 0.0333
Schistosoma mansoni hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Brugia malayi GnHR receptor homolog 0.0026 0.0062 0.0541
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0379 0.2727 0.2365
Schistosoma mansoni amine GPCR 0.0026 0.0062 0.0291
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0062 0.0291
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0062 0.0062
Echinococcus granulosus tar DNA binding protein 0.0061 0.033 0.033
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0063 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Mycobacterium ulcerans thymidine phosphorylase 0.1342 1 1
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0264 0.5572
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0078 0.0498
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0062 0.0062
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0038 0.0804
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0062 0.0291
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0062 0.0541
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Brugia malayi Dopamine receptor protein 1 0.0026 0.0062 0.0541
Schistosoma mansoni biogenic amine receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni amine GPCR 0.0026 0.0062 0.0291
Giardia lamblia GTOR 0.0053 0.0264 1
Brugia malayi G-protein coupled receptor 0.0026 0.0062 0.0541
Loa Loa (eye worm) hypothetical protein 0.0028 0.0078 0.0368
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Brugia malayi hypothetical protein 0.008 0.0474 0.4146
Loa Loa (eye worm) RNA binding protein 0.0061 0.033 0.1555
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0063 0.0297
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Schistosoma mansoni neuropeptide receptor 0.0026 0.0062 0.0291
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1715
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.3424
Brugia malayi putative neuropeptide receptor 0.0026 0.0062 0.0541
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.033 0.2887
Loa Loa (eye worm) hypothetical protein 0.0107 0.0676 0.3184
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0062 0.0062
Brugia malayi G-protein coupled receptor 0.0026 0.0062 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0062 0.0062
Schistosoma mansoni myosin xvIII 0.0026 0.0062 0.0291
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0062 0.0062
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Onchocerca volvulus 0.0032 0.0105 0.0401
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0081 0.1715
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Echinococcus multilocularis lamin 0.0032 0.0105 0.0105
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Schistosoma mansoni lamin 0.0032 0.0105 0.0496
Echinococcus granulosus snurportin 1 0.0299 0.2123 0.2123
Echinococcus granulosus hypothetical protein 0.0026 0.0062 0.0062
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0062 0.0062
Echinococcus granulosus allatostatin A receptor 0.0026 0.0062 0.0062
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0062 0.0291
Schistosoma mansoni hypothetical protein 0.005 0.0241 0.1136
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0022 0.0105
Schistosoma mansoni neuropeptide receptor 0.0026 0.0062 0.0291
Loa Loa (eye worm) TAR-binding protein 0.0061 0.033 0.1555
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0062 0.0062
Schistosoma mansoni ran 0.0021 0.0022 0.0105
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0062 0.0541
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0042 0.0183 0.1602
Echinococcus granulosus neuropeptide receptor 0.0026 0.0062 0.0062
Brugia malayi ORL1-like opioid receptor 0.0026 0.0062 0.0541
Echinococcus multilocularis thymidine phosphorylase 0.1342 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0062 0.0291
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0053 0.0264 0.231
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0022 0.0022
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.005 0.0242 0.114
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.0291
Brugia malayi hypothetical protein 0.0026 0.0062 0.0541
Schistosoma mansoni hypothetical protein 0.0107 0.0676 0.3184

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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