Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Homo sapiens | purine nucleoside phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium bile acid cotransporter | 0.7171 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.7171 | 1 | 1 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0308 | 0 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.2908 | 0.3788 | 0.3788 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0308 | 0 | 0.5 |
Onchocerca volvulus | 0.7171 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.7171 | 1 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.7171 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.7171 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.7171 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.7171 | 1 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0308 | 0 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.4263 | 0.5763 | 0.5763 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.7171 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0308 | 0 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0308 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K6 (binding) | = 0.013 s-1 | Rate constant of compound was determined for interaction with human purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
K6 (binding) | = 0.013 s-1 | Rate constant of compound was determined for interaction with human purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
K6 (binding) | = 0.019 s-1 | Rate constant of compound was determined for interaction with bovine purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
K6 (binding) | = 0.019 s-1 | Rate constant of compound was determined for interaction with bovine purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
Ki (binding) | = 60 pM | Inhibitory activity of compound against bovine purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
Ki (binding) | = 60 pM | Inhibitory activity of compound against bovine purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
Ki (binding) | = 96 pM | Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
Ki (binding) | = 96 pM | Inhibitory activity of compound against human purine nucleoside phosphorylase(PNP) | ChEMBL. | 12502369 |
Ki (binding) | = 3.7 uM | Inhibitory activity of compound against perine-specific inosine-adenosine-guanosine nucleoside hydrolase (IAG-NH) from trypanosoma brucei | ChEMBL. | 12502369 |
Ki (binding) | = 4.8 uM | Inhibitory activity of compound against inosine-uridine nucleoside hydrolase (IU-NH) from crithidia fasciculata | ChEMBL. | 12502369 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.