Detailed information for compound 576280

Basic information

Technical information
  • TDR Targets ID: 576280
  • Name: 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-tri chloro-3-methyl-butanoyl)amino]-N-(1-thiazol- 2-ylethyl)pentanamide
  • MW: 546.166 | Formula: C17H23Cl6N3O2S
  • H donors: 1 H acceptors: 3 LogP: 5.65 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C(N(C(=O)CC(C(Cl)(Cl)Cl)C)C)CC(C(Cl)(Cl)Cl)C)NC(c1nccs1)C
  • InChi: 1S/C17H23Cl6N3O2S/c1-9(16(18,19)20)7-12(14(28)25-11(3)15-24-5-6-29-15)26(4)13(27)8-10(2)17(21,22)23/h5-6,9-12H,7-8H2,1-4H3,(H,25,28)
  • InChiKey: BFVRAKVNXYQMID-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-trichloro-3-methyl-1-oxobutyl)amino]-N-[1-(2-thiazolyl)ethyl]pentanamide
  • 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-trichloro-3-methyl-butanoyl)amino]-N-[1-(1,3-thiazol-2-yl)ethyl]pentanamide
  • 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-trichloro-3-methyl-butanoyl)amino]-N-(1-thiazol-2-ylethyl)valeramide
  • 5,5,5-trichloro-4-methyl-2-[methyl-(4,4,4-trichloro-3-methylbutanoyl)amino]-N-[1-(1,3-thiazol-2-yl)ethyl]pentanamide
  • dysidenin
  • 67528-34-1
  • 65647-65-6
  • Dysidenine
  • Pentanamide, 5,5,5-trichloro-4-methyl-2-(methyl(4,4,4-trichloro-3-methyl-1-oxobutyl)amino)-N-(1-(2-thiazolyl)ethyl)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0189 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0281 0.0318
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Mycobacterium ulcerans glutaminase 0.0275 0.319 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.0281 0.0265
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Onchocerca volvulus 0.0055 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0281 0.0265
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0302 0.3546 0.4227
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi cathepsin B-like cysteine proteinase 0.0302 0.3546 1
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus granulosus neuropeptide receptor 0.0055 0.0281 0.0318
Echinococcus granulosus somatostatin receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0048 0.0189 0.049
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus neuropeptide s receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.0281 0.075
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0051 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Schistosoma mansoni polycystin 1-related 0.0048 0.0189 0.0198
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0281 0.0265
Brugia malayi G protein-coupled receptor 0.0055 0.0281 0.075
Schistosoma mansoni biogenic amine receptor 0.0055 0.0281 0.0309
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0302 0.3546 0.4227
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni opsin-like receptor 0.0055 0.0281 0.0309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Onchocerca volvulus 0.0055 0.0281 1
Brugia malayi G-protein coupled receptor 0.0055 0.0281 0.075
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.0281 0.0309
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni neuropeptide receptor 0.0055 0.0281 0.0309
Echinococcus granulosus muscleblind protein 0.0296 0.3467 0.4138
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi GnHR receptor homolog 0.0055 0.0281 0.075
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0374 0.0358
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0281 0.0265
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0133 0.132 0.1306
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0281 0.0265
Schistosoma mansoni inositol monophosphatase 0.0037 0.0051 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Plasmodium falciparum LCCL domain-containing protein 0.0048 0.0189 1
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0281 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni lipoxygenase 0.0048 0.0189 0.0198
Echinococcus multilocularis Polycystic kidney disease protein 0.0048 0.0189 0.0173
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis cathepsin b 0.0302 0.3546 0.3536
Schistosoma mansoni amine GPCR 0.0055 0.0281 0.0309
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.0281 0.0318
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0374 0.0429
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.0281 0.0265
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0302 0.3546 0.4227
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.0281 0.075
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Schistosoma mansoni histamine h1 receptor 0.0055 0.0281 0.0309
Schistosoma mansoni biogenic amine receptor 0.0055 0.0281 0.0309
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.0281 0.0318
Trichomonas vaginalis glutaminase, putative 0.0275 0.319 1
Loa Loa (eye worm) doublecortin family protein 0.0048 0.0189 0.049
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.0281 0.0265
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0281 0.0265
Brugia malayi putative neuropeptide receptor 0.0055 0.0281 0.075
Brugia malayi ORL1-like opioid receptor 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi Melatonin receptor type 1A 0.0055 0.0281 0.075
Schistosoma mansoni adenoreceptor 0.0055 0.0281 0.0309
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus granulosus neuropeptide receptor 0.0055 0.0281 0.0318
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.0281 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.0281 0.0318
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.0281 0.075
Schistosoma mansoni hypothetical protein 0.0055 0.0281 0.0309
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0281 0.0309
Onchocerca volvulus 0.0055 0.0281 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi Muscleblind-like protein 0.0296 0.3467 0.9776
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.0281 0.0309
Giardia lamblia Cathepsin B precursor 0.01 0.0876 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.01 0.0876 0.2627
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.0281 0.0318
Echinococcus granulosus cathepsin b 0.0302 0.3546 0.4232
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0374 0.1014
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.0281 0.075
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0281 0.075
Schistosoma mansoni inositol monophosphatase 0.0037 0.0051 0.0033
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0281 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni neuropeptide receptor 0.0055 0.0281 0.0309
Brugia malayi AKH receptor 0.0055 0.0281 0.075
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0281 0.0265
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0281 0.0318
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8357 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.0281 0.075
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0281 0.0318
Plasmodium vivax multidomain scavenger receptor, putative 0.0048 0.0189 1
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8357 0.8354
Echinococcus granulosus RUN 0.0048 0.0189 0.0207
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0281 0.0318
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus granulosus g protein coupled receptor 0.0055 0.0281 0.0318
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.0281 0.0265
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus multilocularis allatostatin A receptor 0.0055 0.0281 0.0265
Echinococcus multilocularis serotonin receptor 0.0055 0.0281 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Brugia malayi Dopamine receptor 0.0055 0.0281 0.075
Onchocerca volvulus 0.0055 0.0281 1
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.0281 0.0309
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.0281 0.0265
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0296 0.3467 0.9776
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.0281 0.0318
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0208 0.0221
Schistosoma mansoni lipoxygenase 0.0133 0.132 0.1555
Echinococcus granulosus lipoxygenase domain containing protein 0.0048 0.0189 0.0207
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0281 0.0309
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.0281 0.0265
Trypanosoma brucei cysteine peptidase C (CPC) 0.01 0.0876 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0024 0.0008
Schistosoma mansoni myosin xvIII 0.0055 0.0281 0.0309
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.0281 0.0318
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni hypothetical protein 0.0055 0.0281 0.0309
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0051 0.0406
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.0281 0.075
Brugia malayi G-protein coupled receptor 0.0055 0.0281 0.075
Echinococcus granulosus g protein coupled receptor 0.0055 0.0281 0.0318
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.0281 0.075
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.0281 0.0265
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.0281 0.0265
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.0281 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi RhoGAP domain containing protein 0.0074 0.0537 0.1476
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.0281 0.075
Schistosoma mansoni neuropeptide receptor 0.0055 0.0281 0.0309
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.0281 0.0318
Toxoplasma gondii cathepsin B 0.01 0.0876 1
Echinococcus multilocularis Rac GTPase activating protein 1 0.0074 0.0537 0.0522
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni hypothetical protein 0.0055 0.0281 0.0309
Brugia malayi follicle stimulating hormone receptor 0.0055 0.0281 0.075
Brugia malayi RE15519p 0.0055 0.0281 0.075
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.0281 0.0318
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0048 0.0189 0.049
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.01 0.0876 0.2436
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0302 0.3546 1
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0281 0.0265
Echinococcus granulosus Rac GTPase activating protein 1 0.0074 0.0537 0.0625
Brugia malayi Serotonin receptor 0.0055 0.0281 0.075
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.0281 0.0318
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.0281 0.0309
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.0281 0.0265
Onchocerca volvulus 0.0055 0.0281 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.0281 0.0309
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0281 0.0265
Echinococcus multilocularis RUN 0.0048 0.0189 0.0173
Loa Loa (eye worm) cathepsin B 0.01 0.0876 0.2436
Brugia malayi larval opioid receptor 0.0055 0.0281 0.075
Echinococcus multilocularis cathepsin b 0.0302 0.3546 0.3536
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0189 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0051 0.0406
Echinococcus granulosus Polycystic kidney disease protein 0.0048 0.0189 0.0207
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) inositol-1 0.0037 0.0051 0.0099
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.0281 0.0318
Brugia malayi Serotonin receptor 0.0055 0.0281 0.075
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni rac gtpase activating protein 0.0074 0.0537 0.0616
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.0281 1
Schistosoma mansoni hypothetical protein 0.0048 0.0189 0.0198
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0281 0.0309
Schistosoma mansoni amine GPCR 0.0055 0.0281 0.0309
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0374 0.1029
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni amine GPCR 0.0055 0.0281 0.0309
Echinococcus granulosus serotonin receptor 0.0055 0.0281 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Echinococcus granulosus orexin receptor type 2 0.0055 0.0281 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0208 0.023
Schistosoma mansoni hypothetical protein 0.0055 0.0281 0.0309
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.0281 0.0309
Brugia malayi neuropeptide F receptor 0.0055 0.0281 0.075
Brugia malayi Doublecortin family protein 0.0048 0.0189 0.049
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.0281 0.0265
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.0281 0.0318
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.0281 0.0318
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.0281 0.0309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0208 0.0543
Echinococcus multilocularis somatostatin receptor 0.0055 0.0281 0.0265
Echinococcus granulosus cathepsin b 0.0302 0.3546 0.4232
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0051 0.0099
Onchocerca volvulus 0.0055 0.0281 1
Onchocerca volvulus 0.0055 0.0281 1
Brugia malayi neuropeptide F receptor 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis sex peptide receptor 0.0055 0.0281 0.0265
Echinococcus multilocularis neuropeptide receptor 0.0055 0.0281 0.0265
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.0281 0.0318
Loa Loa (eye worm) glutaminase 0.0275 0.319 0.8992
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.0281 0.075
Loa Loa (eye worm) hypothetical protein 0.0302 0.3546 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis orexin receptor type 2 0.0055 0.0281 0.0265
Schistosoma mansoni hypothetical protein 0.0062 0.0374 0.042
Loa Loa (eye worm) hypothetical protein 0.0074 0.0537 0.1476
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) glutaminase 2 0.0275 0.319 0.8992
Schistosoma mansoni rab6-interacting 0.0048 0.0189 0.0198
Brugia malayi Inositol-1 0.0037 0.0051 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Brugia malayi hypothetical protein 0.0035 0.0024 0.0022
Echinococcus granulosus sex peptide receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0281 0.075
Echinococcus multilocularis fmrfamide receptor 0.0055 0.0281 0.0265
Onchocerca volvulus 0.0055 0.0281 1
Brugia malayi hypothetical protein 0.0048 0.0189 0.049
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.0281 0.0318
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.0281 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis muscleblind protein 1 0.0296 0.3467 0.3457
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.0281 0.0309
Echinococcus multilocularis serotonin receptor 0.0055 0.0281 0.0265
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0051 0.5
Onchocerca volvulus 0.0055 0.0281 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.0281 0.0318
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni biogenic amine receptor 0.0055 0.0281 0.0309
Schistosoma mansoni glutaminase 0.0275 0.319 0.38
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Onchocerca volvulus 0.0055 0.0281 1
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8357 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0302 0.3546 0.4227
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0208 0.0221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Schistosoma mansoni amine GPCR 0.0055 0.0281 0.0309
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0281 0.0309
Echinococcus granulosus g protein coupled receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0064 0.0404 0.1097
Brugia malayi glutaminase DH11.1 0.0275 0.319 0.8992
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Giardia lamblia Cathepsin B precursor 0.01 0.0876 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0208 0.0192
Echinococcus multilocularis muscleblind protein 0.0296 0.3467 0.3457
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Brugia malayi RhoGAP domain containing protein 0.0064 0.0404 0.1097
Schistosoma mansoni loxhd1 0.0048 0.0189 0.0198
Echinococcus granulosus fmrfamide receptor 0.0055 0.0281 0.0318
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.0281 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Schistosoma mansoni amine GPCR 0.0055 0.0281 0.0309
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.0281 0.075
Echinococcus granulosus hypothetical protein 0.0055 0.0281 0.0318
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0208 0.0543
Echinococcus multilocularis lipoxygenase domain containing protein 0.0048 0.0189 0.0173
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.0281 0.0265
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.0281 0.075
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.0281 0.0318
Schistosoma mansoni opsin-like receptor 0.0055 0.0281 0.0309
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.0281 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.0281 0.0265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0208 0.023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0024 0.0009
Giardia lamblia Cathepsin B precursor 0.01 0.0876 1
Echinococcus granulosus allatostatin A receptor 0.0055 0.0281 0.0318
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.0281 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0208 0.0221
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0281 0.0265
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0133 0.132 0.1563
Brugia malayi Dopamine receptor protein 1 0.0055 0.0281 0.075
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.01 0.0876 0.1023
Brugia malayi hypothetical protein 0.0048 0.0189 0.049
Brugia malayi sulfakinin receptor protein 0.0055 0.0281 0.075
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.0281 0.0318
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0051 0.0406
Onchocerca volvulus 0.0055 0.0281 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.0281 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.0281 0.075
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.0281 0.0309
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0051 0.0099
Brugia malayi DnaJ domain containing protein 0.0062 0.0374 0.1014
Loa Loa (eye worm) hypothetical protein 0.0296 0.3467 0.9776
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.0281 0.0309
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.0281 0.0265
Brugia malayi hypothetical protein 0.0055 0.0281 0.075
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0208 0.0192
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.0281 0.075
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0051 0.0035
Brugia malayi Dopamine receptor protein 2 0.0055 0.0281 0.075
Schistosoma mansoni opsin-like receptor 0.0055 0.0281 0.0309
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.0281 0.0309
Loa Loa (eye worm) hypothetical protein 0.0055 0.0281 0.075
Echinococcus granulosus g-protein coupled receptor 0.0055 0.0281 0.0318
Schistosoma mansoni rab6-interacting 0.0048 0.0189 0.0198
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.0281 0.075
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.01 0.0876 1
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.0281 0.075
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.0281 0.075
Echinococcus multilocularis g protein coupled receptor 0.0055 0.0281 0.0265
Schistosoma mansoni neuropeptide receptor 0.0055 0.0281 0.0309
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0051 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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