TDR Targets

Basic information

Technical information

TDR Targets ID: 579071
Name: 620-34-8
MW: 278.307 | Formula: C13H18N4O3
H donors: 2 H acceptors: 3 LogP: -0.35 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: C1N2CN3CN1CN(C2)C3.OC(=O)c1ccccc1O
InChi: 1S/C7H6O3.C6H12N4/c8-6-4-2-1-3-5(6)7(9)10;1-7-2-9-4-8(1)5-10(3-7)6-9/h1-4,8H,(H,9,10);1-6H2
InChiKey: DXPBGQWPULFACQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

EINECS 210-637-8
Methenamine salicylate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0036	0.0825	0.5
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0825	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0825	0.0948
Schistosoma mansoni	hypothetical protein	0.0072	0.2531	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.2531	0.616
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2512	0.9896
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1589	0.4854
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0825	0.0948
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0825	0.5
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0825	0.0691
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0825	1
Brugia malayi	TAR-binding protein	0.0072	0.2512	0.6114
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0825	0.5
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0825	0.5
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0825	0.0948
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1589	0.4905
Loa Loa (eye worm)	RNA binding protein	0.0072	0.2512	0.5598
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0105	0.4108	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0825	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0825	0.0948
Brugia malayi	beta-lactamase	0.0036	0.0825	0.2009
Toxoplasma gondii	ABC1 family protein	0.0036	0.0825	1
Brugia malayi	RNA binding protein	0.0072	0.2512	0.6114
Mycobacterium ulcerans	lipase LipD	0.0036	0.0825	0.5
Loa Loa (eye worm)	hypothetical protein	0.0105	0.4108	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0825	0.0691
Loa Loa (eye worm)	hypothetical protein	0.0033	0.07	0.0602
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.1589	0.4905
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0825	1
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0825	0.5
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1589	0.4905
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0105	0.4108	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0825	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0825	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2531	0.565
Brugia malayi	beta-lactamase family protein	0.0036	0.0825	0.2009
Leishmania major	hypothetical protein, conserved	0.0036	0.0825	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0825	0.2009
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.07	0.0602
Loa Loa (eye worm)	TAR-binding protein	0.0072	0.2512	0.5598
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.07	0.1704
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0825	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.1589	0.3053
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0072	0.2512	0.5598
Onchocerca volvulus		0.0036	0.0825	0.5
Onchocerca volvulus		0.0036	0.0825	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0825	0.5
Brugia malayi	beta-lactamase family protein	0.0036	0.0825	0.2009
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0825	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0825	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0105	0.4108	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.1589	0.3867
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.1589	0.4905
Brugia malayi	RNA recognition motif domain containing protein	0.0072	0.2512	0.6114
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2512	0.9896
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0825	0.0948
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0482	0.5
Trichomonas vaginalis	esterase, putative	0.0036	0.0825	0.5
Echinococcus multilocularis	tar DNA binding protein	0.0072	0.2512	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0825	0.5
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0825	0.0948
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2512	0.9896
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1589	0.4854
Brugia malayi	hypothetical protein	0.0029	0.0482	0.1172
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0825	0.0948
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.1589	0.4854
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0825	0.0684
Echinococcus granulosus	tar DNA binding protein	0.0072	0.2512	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0825	0.0684
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2512	0.9896
Schistosoma mansoni	tar DNA-binding protein	0.0072	0.2512	0.9896
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0825	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0482	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.07	0.1704

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 71548

Bibliographic References

No literature references available for this target.

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Detailed information for compound 579071