TDR Targets

Basic information

Technical information

TDR Targets ID: 579438
Name: 2-(5-isobutyl-1-naphthyl)acetic acid
MW: 242.313 | Formula: C16H18O2
H donors: 1 H acceptors: 2 LogP: 4.23 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(Cc1cccc2c1cccc2CC(=O)O)C
InChi: 1S/C16H18O2/c1-11(2)9-12-5-3-8-15-13(10-16(17)18)6-4-7-14(12)15/h3-8,11H,9-10H2,1-2H3,(H,17,18)
InChiKey: MJPDFVFWDUWGPQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[5-(2-methylpropyl)naphthalen-1-yl]ethanoic acid
2-[5-(2-methylpropyl)naphthalen-1-yl]acetic acid
5-isobutylnaphthalene-1-acetic acid
72221-66-0
1-Naphthaleneacetic acid, 5-(2-methylpropyl)-
5-(2-Methylpropyl)-1-naphthaleneacetic acid
5-Isobutyl-1-naphthaleneacetic acid
Acide isobutyl-5 naphthyl-1 acetique [French]
BRN 2274600

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	NNMT/PNMT/TEMT family protein	0.0267	0.6326	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0255	0.0403
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0018	0.0198	0.5386
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0021	0.0255	0.0255
Brugia malayi	jmjC domain containing protein	0.0097	0.2138	0.338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0294	0.6999	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0475	0.0475
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Schistosoma mansoni	hypothetical protein	0.0416	1	1
Loa Loa (eye worm)	hypothetical protein	0.0267	0.6326	1
Brugia malayi	amine oxidase, flavin-containing family protein	0.0021	0.0255	0.0403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0313	0.6369
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0956	0.1511
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Echinococcus granulosus	peregrin	0.003	0.0475	0.0475
Echinococcus multilocularis	cpg binding protein	0.0031	0.0505	0.0505
Brugia malayi	jmjC domain containing protein	0.0038	0.067	0.1059
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0313	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.1272	0.1272
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0294	0.6999	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0313	0.2625
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0273	0.6488	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.067	0.067
Schistosoma mansoni	cpg binding protein	0.0031	0.0505	0.0505
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0464	0.0734
Leishmania major	UDP-galactopyranose mutase	0.0021	0.0255	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0128	0.0202
Echinococcus granulosus	geminin	0.0167	0.3862	0.3862
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0956	0.1511
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0018	0.0198	0.4987
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0018	0.0198	0.5386
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.1765	0.279
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.1765	0.1765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.028	0.7623
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0198	0.0313
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0023	0.0313	0.5
Plasmodium falciparum	phd finger protein, putative	0.003	0.0475	1
Brugia malayi	PHD-finger family protein	0.0011	0.0024	0.0038
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0128	0.0128
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0018	0.0199	0.541
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0021	0.0255	0.5088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.1254	0.1982
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0128	0.0202
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Loa Loa (eye worm)	hypothetical protein	0.003	0.0475	0.0751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0029	0.0796
Brugia malayi	SWIRM domain containing protein	0.0021	0.0255	0.0403
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0464	0.0734
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0198	0.0313
Echinococcus multilocularis	peregrin	0.003	0.0475	0.0475
Schistosoma mansoni	cpg binding protein	0.0029	0.0464	0.0464
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0475	0.0751
Loa Loa (eye worm)	NNMT/PNMT/TEMT family protein	0.0267	0.6326	1
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0198	0.5386
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0018	0.0198	0.4987
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0018	0.0198	0.4987
Schistosoma mansoni	hypothetical protein	0.0016	0.0128	0.0128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Echinococcus multilocularis	dnaJ subfamily B	0.0416	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0475	0.0475
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0572	0.0905
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0018	0.0199	0.0076
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.1765	0.1765
Onchocerca volvulus		0.0082	0.1765	1
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0367	0.0367
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0629	0.0629
Onchocerca volvulus		0.0029	0.0464	0.1386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.1765	0.1765
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Schistosoma mansoni	cpg binding protein	0.0031	0.0505	0.0505
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.1646	0.1646
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0475	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0367	1
Echinococcus granulosus	cpg binding protein	0.0031	0.0505	0.0505
Trichomonas vaginalis	conserved hypothetical protein	0.0012	0.0029	0.0796
Echinococcus granulosus	GPCR family 2	0.0016	0.0128	0.0128
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0367	0.3131
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0255	0.0403
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0255	0.5088
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0313	0.6369
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0956	0.1511
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0021	0.0255	0.0255
Brugia malayi	hypothetical protein	0.0021	0.0255	0.0403
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0021	0.0255	0.695
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.067	0.067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Brugia malayi	F/Y-rich N-terminus family protein	0.0019	0.0203	0.0321
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0023	0.0313	1
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0367	0.0367
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0018	0.0198	0.5386
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0018	0.0198	0.4987
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.2138	0.2138
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0021	0.0255	0.5088
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0475	0.4133
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0956	0.1511
Plasmodium falciparum	protoporphyrinogen oxidase	0.0021	0.0255	0.5088
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0029	0.0046
Brugia malayi	Bromodomain containing protein	0.003	0.0475	0.0751
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0018	0.0198	0.0198
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0367	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0018	0.0198	0.5386
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0018	0.0198	0.0198
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0018	0.0198	0.0198
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0367	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0255	0.0403
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0128	0.0128
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0313	0.2625
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0022	0.0299	0.25
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.067	0.067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0022	0.028	0.0442
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0313	0.8385
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0255	0.0403
Schistosoma mansoni	hypothetical protein	0.0034	0.0572	0.0572
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0128	0.0128
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0367	0.058
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0018	0.0198	0.4987
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0021	0.0255	0.695
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0018	0.0198	0.0198
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0023	0.0313	0.0085
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0762	0.0762
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0024	0.0038
Giardia lamblia	PHD finger protein 15	0.003	0.0475	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0475	0.4133
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0267	0.6326	1
Echinococcus multilocularis		0.0021	0.0255	0.0255
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0021	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1765	0.279
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0018	0.0198	0.0198
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0128	0.0128
Onchocerca volvulus	Alhambra homolog	0.003	0.0475	0.1458
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0017	0.0162	0.0162
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0018	0.0198	0.0198
Schistosoma mansoni	hypothetical protein	0.0167	0.3862	0.3862
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0128	0.0202
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0255	0.0403
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0572	0.0905
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Entamoeba histolytica	hypothetical protein	0.0023	0.0313	0.8514
Schistosoma mansoni	amine oxidase	0.0021	0.0255	0.0255
Trypanosoma cruzi	target of rapamycin kinase 3	0.0018	0.0198	0.5386
Schistosoma mansoni	amine oxidase	0.0021	0.0255	0.0255
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.067	0.1059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Mycobacterium leprae	conserved hypothetical protein	0.0023	0.0313	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0997	0.1577
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0018	0.0198	0.0313
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0475	0.0475
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0313	0.0092
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0011	0.0021	0.0021
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0128	0.0202
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0021	0.0255	0.5088
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0021	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0255	0.0403
Schistosoma mansoni	hypothetical protein	0.0167	0.3862	0.3862
Loa Loa (eye worm)	phosphatidylinositol 3	0.0018	0.0198	0.0313
Entamoeba histolytica	hypothetical protein	0.0025	0.0367	1
Schistosoma mansoni	hypothetical protein	0.003	0.0475	0.0475
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Schistosoma mansoni	hypothetical protein	0.0016	0.0128	0.0128
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0128	0.0128
Schistosoma mansoni	hypothetical protein	0.0016	0.0128	0.0128
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0018	0.0198	0.1561
Toxoplasma gondii	histone lysine-specific demethylase	0.0021	0.0255	0.2093
Schistosoma mansoni	hypothetical protein	0.0016	0.0128	0.0128
Echinococcus multilocularis	geminin	0.0167	0.3862	0.3862
Plasmodium vivax	hypothetical protein, conserved	0.0021	0.0255	0.5088
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0023	0.0313	0.5
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0011	0.0021	0.0021
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0023	0.0313	0.0085
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0018	0.0198	0.5386
Brugia malayi	PHD-finger family protein	0.003	0.0475	0.0751
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0762	0.0762
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0021	0.0255	0.0255
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0021	0.0255	0.5088
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0018	0.0198	0.5386
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1109	1
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0021	0.0255	0.0255
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.2138	0.2138

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 174983

Bibliographic References

No literature references available for this target.

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Detailed information for compound 579438