Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | 0.0078 | 0.1036 | 0.2504 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0175 | 0.4139 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0058 | 0.039 | 0.0942 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0058 | 0.039 | 0.0942 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0337 | 0.0079 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0106 | 0.1954 | 0.174 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0058 | 0.039 | 0.0942 |
Echinococcus granulosus | carboxylesterase 5A | 0.0106 | 0.1954 | 0.4721 |
Brugia malayi | Carboxylesterase family protein | 0.0106 | 0.1954 | 0.3246 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0175 | 0.4139 | 1 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0058 | 0.039 | 0.0942 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0102 | 0.1797 | 0.2918 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0058 | 0.039 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0175 | 0.4139 | 0.7779 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.039 | 0.0134 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0106 | 0.1954 | 0.4721 |
Brugia malayi | tRNA modification GTPase TrmE family protein | 0.0084 | 0.1219 | 0.172 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0175 | 0.4139 | 0.3983 |
Loa Loa (eye worm) | carboxylesterase | 0.0106 | 0.1954 | 0.174 |
Echinococcus granulosus | acetylcholinesterase | 0.0106 | 0.1954 | 0.4721 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.039 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1954 | 0.174 |
Echinococcus multilocularis | acetylcholinesterase | 0.0106 | 0.1954 | 0.4721 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0058 | 0.039 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0208 | 0.521 | 0.5082 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0208 | 0.521 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0058 | 0.039 | 0.0942 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0175 | 0.4139 | 1 |
Schistosoma mansoni | integrin alpha | 0.0102 | 0.1797 | 0.434 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0058 | 0.039 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0175 | 0.4139 | 1 |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0058 | 0.039 | 0.5 |
Echinococcus multilocularis | gtp binding protein (I) alpha 1subunit | 0.0058 | 0.039 | 0.0942 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1954 | 0.174 |
Echinococcus multilocularis | integrin beta 2 | 0.0154 | 0.3481 | 0.841 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0157 | 0.356 | 0.3388 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1219 | 0.0985 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.1097 | 0.0859 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.1219 | 0.0985 |
Brugia malayi | Carboxylesterase family protein | 0.0106 | 0.1954 | 0.3246 |
Schistosoma mansoni | integrin beta subunit | 0.0122 | 0.2468 | 0.5962 |
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0058 | 0.039 | 0.0942 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0058 | 0.039 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein alpha chain | 0.0058 | 0.039 | 0.0134 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0058 | 0.039 | 0.0942 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0058 | 0.039 | 0.0942 |
Echinococcus granulosus | acetylcholinesterase | 0.0106 | 0.1954 | 0.4721 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0077 | 0.1003 | 0.1273 |
Echinococcus granulosus | integrin alpha 3 | 0.0078 | 0.1036 | 0.2504 |
Loa Loa (eye worm) | heterotrimeric G protein alpha subunit | 0.0058 | 0.039 | 0.0134 |
Echinococcus multilocularis | acetylcholinesterase | 0.0106 | 0.1954 | 0.4721 |
Echinococcus granulosus | gtp binding protein I alpha 1subunit | 0.0058 | 0.039 | 0.0942 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0058 | 0.039 | 0.0942 |
Echinococcus granulosus | integrin beta 2 | 0.0154 | 0.3481 | 0.841 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0106 | 0.1954 | 0.4721 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.039 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.1003 | 0.0763 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.