Detailed information for compound 580203

Basic information

Technical information
  • TDR Targets ID: 580203
  • Name: N'-[[5-(hydroxymethyl)-2-methyl-3-oxo-4-pyrid ylidene]methyl]pyridine-4-carbohydrazide
  • MW: 286.286 | Formula: C14H14N4O3
  • H donors: 3 H acceptors: 4 LogP: -0.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1=CN=C(C(=O)C1=CNNC(=O)c1ccncc1)C
  • InChi: 1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,17,19H,8H2,1H3,(H,18,21)
  • InChiKey: HOYFGBFEIXEDEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[[5-(hydroxymethyl)-2-methyl-3-oxo-4-pyridylidene]methyl]-4-pyridinecarbohydrazide
  • N'-[[5-(hydroxymethyl)-2-methyl-3-oxo-pyridin-4-ylidene]methyl]pyridine-4-carbohydrazide
  • N'-[(3-keto-2-methyl-5-methylol-4-pyridylidene)methyl]isonicotinohydrazide
  • N'-[[5-(hydroxymethyl)-2-methyl-3-oxopyridin-4-ylidene]methyl]pyridine-4-carbohydrazide
  • pyridoxal isonicotinoyl hydrazone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.2478 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0129 0.0382 1
Schistosoma mansoni hypothetical protein 0.0337 0.1234 1
Entamoeba histolytica hypothetical protein 0.0129 0.0382 1
Entamoeba histolytica hypothetical membrane-spanning protein 0.0129 0.0382 1
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0129 0.0382 1
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0129 0.0382 0.1209
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0129 0.0382 0.0382
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0517 0.0517
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.3161 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0129 0.0382 1
Schistosoma mansoni hypothetical protein 0.0337 0.1234 1
Schistosoma mansoni alpha-glucosidase 0.014 0.0425 0.3442
Echinococcus multilocularis tumor protein p63 0.0352 0.1295 0.4098
Plasmodium vivax sphingomyelin synthase 1, putative 0.0129 0.0382 0.5
Entamoeba histolytica hypothetical protein 0.0129 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0382 0.0382
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0517 0.1636
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0129 0.0382 0.5
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0064 0.0516
Loa Loa (eye worm) hypothetical protein 0.0052 0.0064 0.0064
Trichomonas vaginalis hypothetical protein 0.0129 0.0382 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0517 0.1636
Brugia malayi Sphingomyelin synthase-related 1 0.0129 0.0382 0.0382
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0129 0.0382 1
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0129 0.0382 0.5
Loa Loa (eye worm) hypothetical protein 0.0129 0.0382 0.0382
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0129 0.0382 0.5
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0129 0.0382 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0382 0.0382
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0129 0.0382 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0129 0.0382 0.0382
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0129 0.0382 1
Entamoeba histolytica hypothetical protein 0.0129 0.0382 1
Echinococcus multilocularis geminin 0.0337 0.1234 0.3903
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0129 0.0382 0.0382
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0129 0.0382 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0129 0.0382 1
Onchocerca volvulus 0.0094 0.0237 1
Schistosoma mansoni spingomyelin synthetase-related 0.0129 0.0382 0.3097
Schistosoma mansoni alpha-glucosidase 0.014 0.0425 0.3442
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0129 0.0382 1
Echinococcus granulosus tumor protein p63 0.0352 0.1295 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0129 0.0382 1
Toxoplasma gondii hypothetical protein 0.0129 0.0382 1
Echinococcus granulosus sphingomyelin synthase protein 1 0.0129 0.0382 0.295
Loa Loa (eye worm) hypothetical protein 0.0129 0.0382 0.0382
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0517 0.0517
Trypanosoma brucei inositol phosphorylceramide synthase 0.0129 0.0382 1
Entamoeba histolytica hypothetical protein 0.0129 0.0382 1
Echinococcus granulosus geminin 0.0337 0.1234 0.9525
Entamoeba histolytica hypothetical protein 0.0129 0.0382 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0517 0.3993
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0129 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0129 0.0382 0.0382
Plasmodium vivax sphingomyelin synthase 2, putative 0.0129 0.0382 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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