Detailed view for TVAG_032140

Basic information

TDR Targets ID: 903119
Trichomonas vaginalis, sphingomyelin synthetase, putative
Source Database / ID: 

pI: 8.3204 | Length (AA): 275 | MW (Da): 31461 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF14360   PAP2 superfamily C-terminal

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134360)

Species Accession Gene Product
Homo sapiens ENSG00000164023   sphingomyelin synthase 2
Mus musculus ENSMUSG00000050931   sphingomyelin synthase 2
Trypanosoma brucei gambiense Tbg972.9.5360   phosphatidylcholine:ceramide cholinephosphotransferase 2, putative
Trypanosoma brucei gambiense Tbg972.9.5370   phosphatidylcholine:ceramide cholinephosphotransferase 2, putative
Trypanosoma brucei gambiense Tbg972.9.5320   phosphatidylcholine:ceramide cholinephosphotransferase 2, putative
Trypanosoma brucei Tb927.9.9410   inositol phosphorylceramide synthase
Theileria parva TP04_0631   hypothetical protein
Trichomonas vaginalis TVAG_123040   sphingomyelin synthetase, putative
Trichomonas vaginalis TVAG_032140   sphingomyelin synthetase, putative

Essentiality

TVAG_032140 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1030 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1030 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1030 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb09.211.1030 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens sphingomyelin synthase 2 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0289 0.2523 0
0.1018 0.757 0.8465
0.1019 1 1
0.072 0.8002 1
0.072 0.8002 1
0.0793 1 1
0.1018 0.757 0.8465
0.1018 0.757 0.8465
0.1058 1 1
0.1018 0.757 0.8465
0.0799 0.905 1
0.1018 0.757 0.8465
0.0238 0.2921 0.4985
0.1019 1 1
0.1018 0.757 0.8465
0.0289 1 1
0.1018 0.757 0.8465
0.1018 0.757 0.8465
0.1046 1 1
0.0277 0.7706 0
0.0791 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_032140 (Trichomonas vaginalis), sphingomyelin synthetase, putative
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