Detailed information for compound 581173

Basic information

Technical information
  • TDR Targets ID: 581173
  • Name: N-(3,3-diphenylpropyl)pyridin-4-amine
  • MW: 288.386 | Formula: C20H20N2
  • H donors: 1 H acceptors: 1 LogP: 4.6 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C(c1ccccc1)CCNc1ccncc1
  • InChi: 1S/C20H20N2/c1-3-7-17(8-4-1)20(18-9-5-2-6-10-18)13-16-22-19-11-14-21-15-12-19/h1-12,14-15,20H,13,16H2,(H,21,22)
  • InChiKey: KMZHYAUKFHLFNY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,3-diphenylpropyl)-4-pyridinamine
  • 3,3-diphenylpropyl(4-pyridyl)amine
  • milverine
  • N-[3,3-di(phenyl)propyl]pyridin-4-amine
  • N-[3,3-di(phenyl)propyl]-4-pyridinamine
  • 3,3-di(phenyl)propyl-(4-pyridyl)amine
  • 75437-14-8
  • 4-((3,3-Diphenylpropyl)amino)pyridine
  • Milverina [Spanish]
  • Milverine [INN]
  • Milverinum [Latin]
  • Pyridine, 4-((3,3-diphenylpropyl)amino)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.1025 0.3922
Mycobacterium tuberculosis Conserved protein 0.0026 0.0107 0.0409
Schistosoma mansoni hypothetical protein 0.0068 0.0638 0.0757
Echinococcus multilocularis geminin 0.0684 0.8432 0.8432
Echinococcus granulosus geminin 0.0684 0.8432 1
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0224 0.2612 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0224 0.2612 1
Schistosoma mansoni hypothetical protein 0.0041 0.0297 0.0353
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0317 0.0375
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0407 0.1557
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.1363 0.5216
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0107 0.0409
Loa Loa (eye worm) IMP dehydrogenase 1 0.0224 0.2612 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.018 0.0213
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.161 0.191
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0107 0.0409
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0107 0.0409
Leishmania major inosine-5-monophosphate dehydrogenase 0.0224 0.2612 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0392 0.0392
Schistosoma mansoni hypothetical protein 0.0031 0.018 0.0213
Schistosoma mansoni hypothetical protein 0.0684 0.8432 1
Schistosoma mansoni microtubule-associated protein tau 0.0673 0.8291 0.9833
Schistosoma mansoni hypothetical protein 0.0031 0.018 0.0213
Schistosoma mansoni lamin 0.0026 0.0117 0.0138
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0107 0.0409
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0407 0.0407
Brugia malayi intermediate filament protein 0.0026 0.0117 0.0447
Schistosoma mansoni hypothetical protein 0.0041 0.0297 0.0353
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0224 0.2612 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.1363 0.2083
Plasmodium vivax glutathione reductase, putative 0.0049 0.0407 0.1557
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.018 0.0213
Entamoeba histolytica hypothetical protein 0.0108 0.1155 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0107 0.0127
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0117 0.0024
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0224 0.2612 1
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0107 0.0409
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.161 0.6164
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.1155 0.1369
Brugia malayi CHE-14 protein 0.0042 0.0317 0.1212
Echinococcus granulosus expressed conserved protein 0.0092 0.0949 0.1126
Loa Loa (eye worm) hypothetical protein 0.0052 0.0436 0.1302
Loa Loa (eye worm) hypothetical protein 0.0098 0.1025 0.3653
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.2585 0.9895
Trypanosoma brucei trypanothione reductase 0.0049 0.0407 0.1557
Schistosoma mansoni hypothetical protein 0.0041 0.0297 0.0353
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0317 0.0375
Trypanosoma brucei GMP reductase 0.0224 0.2612 1
Schistosoma mansoni hypothetical protein 0.0041 0.0297 0.0353
Onchocerca volvulus Putative GMP reductase 0.0099 0.1034 1
Leishmania major guanosine monophosphate reductase 0.0224 0.2612 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.1204 0.461
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.161 0.161
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.1557 0.1557
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0407 0.1557
Schistosoma mansoni hypothetical protein 0.0031 0.018 0.0213
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0099 0.1034 0.3957
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0394 0.0467
Brugia malayi hypothetical protein 0.0108 0.1155 0.442
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.1034 0.3689
Plasmodium falciparum glutathione reductase 0.0049 0.0407 0.1557
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.1363 0.5216
Brugia malayi Thioredoxin reductase 0.0049 0.0407 0.1557
Schistosoma mansoni intermediate filament proteins 0.0026 0.0117 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0117 0.0024
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0117 0.0447
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0 0.5
Brugia malayi glutathione reductase 0.0049 0.0407 0.1557
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.1204 0.461
Trypanosoma cruzi GMP reductase 0.0224 0.2612 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0321 1
Entamoeba histolytica hypothetical protein 0.0108 0.1155 1
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.1557 0.1846
Loa Loa (eye worm) hypothetical protein 0.0042 0.0317 0.0823
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0277 1
Echinococcus multilocularis GPCR, family 2 0.0031 0.018 0.018
Leishmania major hypothetical protein, conserved 0.0221 0.2585 0.9895
Loa Loa (eye worm) glutathione reductase 0.0049 0.0407 0.1184
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0224 0.2612 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.1204 0.461
Loa Loa (eye worm) GMP reductase 0.0099 0.1034 0.369
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0224 0.2612 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.1034 0.3957
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0321 1
Echinococcus multilocularis musashi 0.0026 0.0117 0.0117
Brugia malayi Latrophilin receptor protein 2 0.0031 0.018 0.0687
Entamoeba histolytica hypothetical protein 0.0108 0.1155 1
Echinococcus granulosus microtubule associated protein 2 0.0673 0.8291 0.9833
Schistosoma mansoni patched 1 0.0042 0.0317 0.0375
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0224 0.2612 1
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.2585 0.9895
Schistosoma mansoni hypothetical protein 0.0108 0.1155 0.1369
Echinococcus granulosus lamin dm0 0.0026 0.0117 0.0138
Entamoeba histolytica hypothetical protein 0.0108 0.1155 1
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0107 0.3324
Treponema pallidum NADH oxidase 0.0017 0 0.5
Plasmodium falciparum thioredoxin reductase 0.0049 0.0407 0.1557
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0224 0.2612 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0407 0.1557
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0276
Echinococcus multilocularis tumor protein p63 0.0329 0.3949 0.3949
Schistosoma mansoni hypothetical protein 0.0684 0.8432 1
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0117 0.0024
Brugia malayi GMP reductase 0.0099 0.1034 0.3957
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.1363 0.5216
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.1025 0.1025
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.1204 0.108
Mycobacterium ulcerans hypothetical protein 0.0026 0.0107 0.0409
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0321 0.123
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.1044 0.1238
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0317 0.0823
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0107 0.0409
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.1034 0.3957
Echinococcus granulosus GPCR family 2 0.0031 0.018 0.0213
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0125 0.1363 0.5217
Trypanosoma cruzi GMP reductase 0.0224 0.2612 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.1204 0.461
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.1025 0.1215
Onchocerca volvulus 0.0048 0.0394 0.3023
Echinococcus multilocularis microtubule associated protein 2 0.0673 0.8291 0.8291
Toxoplasma gondii IMP dehydrogenas 0.0224 0.2612 1
Echinococcus multilocularis lamin 0.0026 0.0117 0.0117
Leishmania major trypanothione reductase 0.0049 0.0407 0.1557
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0224 0.2612 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0407 0.0482
Mycobacterium ulcerans hypothetical protein 0.0026 0.0107 0.0409
Echinococcus multilocularis expressed conserved protein 0.0092 0.0949 0.0949
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0224 0.2612 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.1204 0.461
Echinococcus granulosus lamin 0.0026 0.0117 0.0138
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0321 0.0381
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0107 0.0409
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0224 0.2612 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0031 0.018 0.0213
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0317 0.0317
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.018 0.018
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0099 0.1034 0.3957
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.1025 0.8519
Echinococcus multilocularis protein patched 0.0042 0.0317 0.0317
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0321 0.123
Loa Loa (eye worm) hypothetical protein 0.0099 0.1034 0.3689
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.018 0.0687
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.1155 0.1369
Echinococcus granulosus intermediate filament protein 0.0026 0.0117 0.0138
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0224 0.2612 0.3098
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0224 0.2612 0.2612
Echinococcus multilocularis lamin dm0 0.0026 0.0117 0.0117
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0277 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0317 0.9854
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0224 0.2612 0.3098
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0407 0.1184
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0224 0.2612 1
Schistosoma mansoni lamin 0.0026 0.0117 0.0138
Mycobacterium tuberculosis Probable reductase 0.0112 0.1204 0.461
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0321 0.123
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.1559 0.1849
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0125 0.1363 0.2085
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.1155 0.1155
Toxoplasma gondii thioredoxin reductase 0.0049 0.0407 0.1557
Loa Loa (eye worm) hypothetical protein 0.0068 0.0638 0.2109
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0638 0.2443
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0099 0.1034 0.3957
Loa Loa (eye worm) hypothetical protein 0.0048 0.0394 0.1132
Loa Loa (eye worm) acetyltransferase 0.0144 0.161 0.5994
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.2585 0.9895
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0107 0.0107
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.018 0.0276
Echinococcus granulosus tumor protein p63 0.0329 0.3949 0.4684

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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