Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0148 | 0.0445 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | DNA-directed DNA polymerase III | 0.0075 | 0.3324 | 0.3224 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.019 | 1 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0148 | 0.0148 |
Echinococcus granulosus | dna polymerase epsilon catalytic subunit a | 0.0025 | 0.0418 | 0.0418 |
Loa Loa (eye worm) | hypothetical protein | 0.019 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0148 | 0.0148 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0148 | 0.0148 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.1912 | 0.1791 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0418 | 0.0274 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0115 | 0.566 | 0.8837 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1091 | 0.1091 |
Echinococcus granulosus | DNA polymerase zeta catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Trichomonas vaginalis | DNA polymerase zeta catalytic subunit, putative | 0.0075 | 0.3324 | 0.3324 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0148 | 0.0148 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Leishmania major | trypanothione reductase | 0.0051 | 0.1912 | 0.1912 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1212 | 0.1212 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.6405 | 1 |
Trypanosoma brucei | DNA polymerase epsilon catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.019 | 1 | 1 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0148 | 0.0445 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0115 | 0.566 | 0.8837 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0148 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.1912 | 0.5752 |
Giardia lamblia | DNA polymerase epsilon, catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.019 | 1 | 1 |
Plasmodium vivax | DNA polymerase epsilon, catalytic subunit a, putative | 0.0025 | 0.0418 | 0.1256 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0025 | 0.0418 | 0.0418 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1212 | 0.1212 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.1912 | 0.5752 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0115 | 0.566 | 0.8837 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.019 | 1 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0148 | 0.0231 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.2065 | 0.1946 |
Schistosoma mansoni | DNA polymerase delta catalytic subunit | 0.0075 | 0.3324 | 0.3324 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0025 | 0.0418 | 0.1256 |
Toxoplasma gondii | DNA polymerase family B protein | 0.0025 | 0.0418 | 0.1256 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1212 | 0.108 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1212 | 0.1212 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0148 | 0.0148 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1212 | 0.108 |
Echinococcus granulosus | DNA polymerase delta catalytic subunit | 0.0075 | 0.3324 | 0.3324 |
Schistosoma mansoni | DNA polymerase zeta catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Plasmodium vivax | DNA polymerase zeta catalytic subunit, putative | 0.0025 | 0.0418 | 0.1256 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2065 | 0.1946 |
Brugia malayi | DNA polymerase family B containing protein | 0.0025 | 0.0418 | 0.0418 |
Trichomonas vaginalis | conserved hypothetical protein | 0.019 | 1 | 1 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0061 | 0.2529 | 0.2529 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.1912 | 0.1912 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1212 | 0.108 |
Trichomonas vaginalis | DNA polymerase delta catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Toxoplasma gondii | DNA polymerase | 0.0075 | 0.3324 | 1 |
Schistosoma mansoni | DNA polymerase epsilon catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0148 | 1 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.019 | 1 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0051 | 0.1912 | 0.1912 |
Brugia malayi | glutathione reductase | 0.0051 | 0.1912 | 0.1912 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0051 | 0.1912 | 0.1912 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0148 | 0.0148 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.1912 | 0.5752 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.6405 | 1 |
Trypanosoma cruzi | DNA polymerase delta catalytic subunit, putative | 0.0075 | 0.3324 | 0.3324 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1212 | 0.108 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.9471 | 0.9471 |
Echinococcus multilocularis | DNA polymerase delta catalytic subunit | 0.0075 | 0.3324 | 0.3324 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.1912 | 0.5752 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.1912 | 0.5752 |
Giardia lamblia | DNA polymerase delta, catalytic subunit | 0.0075 | 0.3324 | 0.3324 |
Echinococcus granulosus | geminin | 0.0181 | 0.9471 | 0.9471 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.9471 | 0.9471 |
Leishmania major | DNA polymerase delta catalytic subunit, putative | 0.0075 | 0.3324 | 0.3324 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.1912 | 0.1912 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.019 | 1 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0148 | 0.0148 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0115 | 0.566 | 0.8837 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0148 | 0.0148 |
Brugia malayi | DNA polymerase family B, exonuclease domain containing protein | 0.0025 | 0.0418 | 0.0418 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1212 | 0.1212 |
Plasmodium falciparum | DNA polymerase delta catalytic subunit | 0.0075 | 0.3324 | 1 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1212 | 0.1212 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1091 | 0.1091 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0148 | 1 |
Onchocerca volvulus | DNA polymerase delta catalytic subunit homolog | 0.0075 | 0.3324 | 1 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0148 | 0.0148 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0148 | 0.0148 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.019 | 1 | 1 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.019 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.1912 | 0.1791 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.019 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.019 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0148 | 0.0148 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.019 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.1912 | 0.1912 |
Trypanosoma cruzi | DNA polymerase epsilon catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Entamoeba histolytica | DNA polymerase delta catalytic subunit, putative | 0.0075 | 0.3324 | 0.3224 |
Brugia malayi | DNA polymerase delta catalytic subunit | 0.0075 | 0.3324 | 0.3324 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.019 | 1 | 1 |
Echinococcus multilocularis | dna polymerase epsilon catalytic subunit a | 0.0025 | 0.0418 | 0.0418 |
Trypanosoma brucei | DNA polymerase zeta catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.6405 | 1 |
Plasmodium vivax | DNA polymerase delta catalytic subunit, putative | 0.0075 | 0.3324 | 1 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase delta catalytic subunit, putative | 0.0075 | 0.3324 | 0.3324 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0051 | 0.1912 | 0.2985 |
Echinococcus multilocularis | DNA polymerase zeta catalytic subunit | 0.0025 | 0.0418 | 0.0418 |
Mycobacterium tuberculosis | Probable reductase | 0.0115 | 0.566 | 0.8837 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.2065 | 0.2065 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1091 | 0.0957 |
Echinococcus multilocularis | geminin | 0.0181 | 0.9471 | 0.9471 |
Leishmania major | DNA polymerase epsilon catalytic subunit, putative | 0.0025 | 0.0418 | 0.0418 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.019 | 1 | 1 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0115 | 0.566 | 0.8837 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.019 | 1 | 1 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0025 | 0.0418 | 0.1256 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.2065 | 0.2065 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.6405 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0148 | 0.0445 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0148 | 0.0148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.