Detailed information for compound 583757

Basic information

Technical information
  • TDR Targets ID: 583757
  • Name: dichloro(diphenyl)silane
  • MW: 253.199 | Formula: C12H10Cl2Si
  • H donors: 0 H acceptors: 0 LogP: 5.15 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cl[Si](c1ccccc1)(c1ccccc1)Cl
  • InChi: 1S/C12H10Cl2Si/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H
  • InChiKey: OSXYHAQZDCICNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dichlorodiphenylsilane
  • dichloro-di(phenyl)silane
  • 155684-38-1
  • 80-10-4
  • Diphenyl dichlorosilane
  • Diphenyldichlorosilane [UN1769] [Corrosive]
  • Diphenylsilyl dichloride
  • EINECS 201-251-0
  • HSDB 316
  • NSC 77110
  • TSL 8062
  • UN1769
  • NCGC00163994-01
  • Diphenyldichlorosilane
  • Diphenylsilicon dichloride
  • NSC77110
  • Silane, dichlorodiphenyl-
  • WLN: G-SI-GR&R
  • 440124_ALDRICH
  • Dow Corning product Z-1223
  • InChI=1/C12H10Cl2Si/c13-15(14,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10
  • D61504_ALDRICH
  • 4-16-00-01526 (Beilstein Handbook Reference)
  • AI3-51461
  • BRN 0609882
  • Dichlor-difenylsilan [Czech]

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi diacylglycerol kinase, putative 0.004 0 0.5
Trypanosoma cruzi Sphingosine kinase 0.004 0 0.5
Echinococcus multilocularis sphingosine kinase 1 0.1028 1 1
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.004 0 0.5
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.004 0 0.5
Schistosoma mansoni sphingosine kinase A B 0.1028 1 1
Echinococcus multilocularis muscleblind protein 1 0.0161 0.1223 0.1223
Trypanosoma cruzi Sphingosine kinase 0.004 0 0.5
Leishmania major diacylglycerol kinase-like protein 0.004 0 0.5
Schistosoma mansoni gabp alpha 0.0078 0.0384 0.0384
Plasmodium falciparum diacylglycerol kinase, putative 0.004 0 0.5
Brugia malayi Muscleblind-like protein 0.0161 0.1223 0.6142
Leishmania major sphingosine kinase A, B, putative 0.004 0 0.5
Trypanosoma cruzi diacylglycerol kinase, putative 0.004 0 0.5
Trichomonas vaginalis bmru protein, putative 0.004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.1028 1 1
Loa Loa (eye worm) RNA binding protein 0.0134 0.0948 0.0948
Trypanosoma cruzi hypothetical protein, conserved 0.004 0 0.5
Leishmania major diacylglycerol kinase, putative 0.004 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0948 0.0948
Echinococcus multilocularis muscleblind protein 0.0161 0.1223 0.1223
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0134 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0127 0.0876 0.0876
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.004 0 0.5
Leishmania major hypothetical protein, conserved 0.004 0 0.5
Trypanosoma brucei diacylglycerol kinase, putative 0.004 0 0.5
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.004 0 0.5
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0078 0.0384 0.0384
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0948 0.0948
Brugia malayi RNA recognition motif domain containing protein 0.0134 0.0948 0.4761
Trichomonas vaginalis diacylglycerol kinase, putative 0.004 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.004 0 0.5
Echinococcus multilocularis GA binding protein alpha chain 0.0078 0.0384 0.0384
Brugia malayi Fli-1 protein 0.0237 0.1991 1
Echinococcus granulosus tar DNA binding protein 0.0134 0.0948 0.0948
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.004 0 0.5
Schistosoma mansoni ets-related 0.0237 0.1991 0.1991
Mycobacterium tuberculosis Conserved protein 0.1028 1 1
Plasmodium vivax diacylglycerol kinase, putative 0.004 0 0.5
Trypanosoma brucei hypothetical protein, conserved 0.004 0 0.5
Loa Loa (eye worm) fli-1 protein 0.0237 0.1991 0.1991
Loa Loa (eye worm) hypothetical protein 0.0161 0.1223 0.1223
Trichomonas vaginalis sphingosine kinase, putative 0.004 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0948 0.0948
Echinococcus multilocularis tar DNA binding protein 0.0134 0.0948 0.0948
Loa Loa (eye worm) hypothetical protein 0.0067 0.0269 0.0269
Schistosoma mansoni sphingoid long chain base kinase 0.1028 1 1
Loa Loa (eye worm) TAR-binding protein 0.0134 0.0948 0.0948
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.004 0 0.5
Onchocerca volvulus Huntingtin homolog 0.0127 0.0876 1
Onchocerca volvulus Huntingtin homolog 0.0127 0.0876 1
Trichomonas vaginalis sphingosine kinase, putative 0.004 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0948 0.0948
Schistosoma mansoni tar DNA-binding protein 0.0134 0.0948 0.0948
Trypanosoma brucei Sphingosine kinase 0.004 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0127 0.0876 0.0876
Brugia malayi hypothetical protein 0.0127 0.0876 0.4402
Brugia malayi Ets-domain containing protein 0.0078 0.0384 0.1929
Toxoplasma gondii diacylglycerol kinase, putative 0.004 0 0.5
Trichomonas vaginalis diacylglycerol kinase, putative 0.004 0 0.5
Echinococcus granulosus GA binding protein alpha chain 0.0078 0.0384 0.0384
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.004 0 0.5
Echinococcus granulosus muscleblind protein 0.0161 0.1223 0.1223
Trichomonas vaginalis bmru protein, putative 0.004 0 0.5
Brugia malayi RNA binding protein 0.0134 0.0948 0.4761
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.004 0 0.5
Brugia malayi Ets-domain containing protein 0.0078 0.0384 0.1929
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.004 0 0.5
Entamoeba histolytica hypothetical protein, conserved 0.1028 1 1
Plasmodium falciparum diacylglycerol kinase, putative 0.004 0 0.5
Leishmania major hypothetical protein, conserved 0.004 0 0.5
Brugia malayi TAR-binding protein 0.0134 0.0948 0.4761
Loa Loa (eye worm) hypothetical protein 0.0161 0.1223 0.1223
Plasmodium vivax diacylglycerol kinase, putative 0.004 0 0.5
Mycobacterium ulcerans hypothetical protein 0.1028 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS assay for small molecule activators of the rat pregnane X receptor (rPXR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 54.4827 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0806 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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