TDR Targets

Basic information

Technical information

TDR Targets ID: 586043
Name: 1,3-benzothiazol-6-yl-[4-(1-piperidyl)phenyl] diazene
MW: 322.427 | Formula: C18H18N4S
H donors: 0 H acceptors: 1 LogP: 5.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C1CCN(CC1)c1ccc(cc1)N=Nc1ccc2c(c1)scn2
InChi: 1S/C18H18N4S/c1-2-10-22(11-3-1)16-7-4-14(5-8-16)20-21-15-6-9-17-18(12-15)23-13-19-17/h4-9,12-13H,1-3,10-11H2/b21-20+
InChiKey: JJHFCAQYAWOWNC-QZQOTICOSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1,3-benzothiazol-6-yl-(4-piperidin-1-ylphenyl)diazene
1,3-benzothiazol-6-yl-(4-piperidinophenyl)diazene
6-(4-N-piperidinylphenyl)azobenzothiazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0402	0.4762	0.829
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.0649	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0078	0.067	0.1167
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	0.5
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0019	0.0296
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.067	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.067	0.1167
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0649	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0078	0.067	0.116
Schistosoma mansoni	regulator of G protein signaling	0.0078	0.067	0.0957
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.0649	0.0919
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.029	0.3348	0.3258
Schistosoma mansoni	regulator of G protein signaling	0.0078	0.067	0.0957
Schistosoma mansoni	serine/threonine protein kinase	0.0368	0.433	0.748
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0368	0.433	0.4253
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0078	0.067	0.0544
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0078	0.067	0.116
Echinococcus granulosus	regulator of G protein signaling 3	0.0078	0.067	0.116
Schistosoma mansoni	regulator of G protein signaling	0.0078	0.067	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0078	0.067	0.1167
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0078	0.067	0.0957
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.048	0.5744	1
Echinococcus multilocularis	regulator of G protein signaling	0.0078	0.067	0.0544
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0402	0.4762	0.4691
Echinococcus granulosus	axis inhibition protein axin	0.0078	0.067	0.116
Brugia malayi	A-kinase anchor protein 10, precursor	0.0078	0.067	0.1167
Brugia malayi	hypothetical protein	0.0035	0.0133	0.0232
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0078	0.067	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0078	0.067	0.1167
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	0.5
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.048	0.5744	1
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0402	0.4762	0.829
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.067	0.5
Echinococcus multilocularis	regulator of G protein signaling 3	0.0078	0.067	0.0544
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0402	0.4762	1
Toxoplasma gondii	hypothetical protein	0.0026	0.0019	0.0296
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	0.5
Schistosoma mansoni	axis inhibition protein axin	0.0078	0.067	0.0957
Echinococcus multilocularis	regulator of G protein signaling 3	0.0078	0.067	0.0544
Leishmania major	hypothetical protein, conserved	0.0025	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.067	0.5
Brugia malayi	Muscleblind-like protein	0.0146	0.1536	0.2675
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.0318	0.5
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1536	0.2675
Schistosoma mansoni	regulator of G protein signaling	0.0078	0.067	0.0957
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0078	0.067	0.0957
Brugia malayi	hypothetical protein	0.0078	0.067	0.1167
Echinococcus granulosus	G protein coupled receptor kinase 1	0.029	0.3348	0.6945
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0	0.5
Echinococcus granulosus	regulator of G protein signaling 3	0.0078	0.067	0.116
Brugia malayi	PXA domain containing protein	0.0078	0.067	0.1167
Entamoeba histolytica	hypothetical protein	0.0078	0.067	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0019	0.0296
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.067	0.1167
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.067	0.5
Loa Loa (eye worm)	hypothetical protein	0.0078	0.067	0.1167
Echinococcus multilocularis	regulator of G protein signaling 7	0.0078	0.067	0.0544
Echinococcus granulosus	Regulator of G protein signaling 20	0.0078	0.067	0.116
Echinococcus granulosus	regulator of G protein signaling 7	0.0078	0.067	0.116
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0078	0.067	0.5
Echinococcus multilocularis	axis inhibition protein axin	0.0078	0.067	0.0544
Echinococcus granulosus	expressed protein	0.0078	0.067	0.116
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.1536	0.1422
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0078	0.067	0.1167
Entamoeba histolytica	hypothetical protein	0.0078	0.067	1
Schistosoma mansoni	serine/threonine protein kinase	0.048	0.5744	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0078	0.067	0.1167
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0078	0.067	0.0544
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.0649	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0368	0.433	0.7538
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0078	0.067	0.0957
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0649	0.113
Echinococcus granulosus	axis inhibition protein axin	0.0078	0.067	0.116
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	1
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1536	0.2675
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0402	0.4762	0.829
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	0.5
Echinococcus multilocularis	regulator of G protein signaling 7	0.0078	0.067	0.0544
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.0318	0.5
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0078	0.067	0.1167
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.0318	0.0187
Entamoeba histolytica	hypothetical protein	0.0078	0.067	1
Brugia malayi	PXA domain containing protein	0.0078	0.067	0.1167
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0	0.5
Echinococcus granulosus	muscleblind protein	0.0146	0.1536	0.3031
Echinococcus multilocularis	expressed protein	0.0078	0.067	0.0544
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.0649	0.1115
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.0649	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.0649	0.5
Echinococcus multilocularis	axis inhibition protein axin	0.0078	0.067	0.0544
Echinococcus multilocularis	muscleblind protein	0.0146	0.1536	0.1422
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.0649	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0368	0.433	0.9067
Schistosoma mansoni	axis inhibition protein axin	0.0078	0.067	0.0957
Brugia malayi	Probable ClpP-like protease	0.0076	0.0649	0.113
Loa Loa (eye worm)	PXA domain-containing protein	0.0078	0.067	0.1167
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.0318	0.4744
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.067	0.5
Brugia malayi	regulator of G-protein signaling rgs-7	0.0078	0.067	0.1167
Brugia malayi	hypothetical protein	0.0078	0.067	0.1167
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.0318	0.0399
Schistosoma mansoni	z-protein (S1r protein)	0.0078	0.067	0.0957
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.067	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0368	0.433	0.748
Schistosoma mansoni	regulator of G protein signaling	0.0078	0.067	0.0957
Loa Loa (eye worm)	RGS-3 protein	0.0078	0.067	0.1167

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by CAS
PubChem: 128635

Bibliographic References

No literature references available for this target.

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Detailed information for compound 586043