Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.067 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1536 | 0.2675 |
Brugia malayi | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0649 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.1115 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0368 | 0.433 | 0.748 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0078 | 0.067 | 0.116 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0078 | 0.067 | 0.0544 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0078 | 0.067 | 0.116 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0078 | 0.067 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1536 | 0.2675 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0649 | 0.0919 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0078 | 0.067 | 0.0957 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0649 | 1 |
Echinococcus multilocularis | axis inhibition protein axin | 0.0078 | 0.067 | 0.0544 |
Echinococcus multilocularis | A kinase anchor protein 10, mitochondrial | 0.0078 | 0.067 | 0.0544 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0078 | 0.067 | 0.1167 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0019 | 0.0296 |
Brugia malayi | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Echinococcus multilocularis | Regulator of G protein signaling 20 | 0.0078 | 0.067 | 0.0544 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.067 | 1 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0078 | 0.067 | 0.0544 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.029 | 0.3348 | 0.3258 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.5 |
Brugia malayi | PXA domain containing protein | 0.0078 | 0.067 | 0.1167 |
Echinococcus granulosus | axis inhibition protein axin | 0.0078 | 0.067 | 0.116 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0368 | 0.433 | 0.9067 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | regulator of G protein signaling 3 | 0.0078 | 0.067 | 0.116 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.067 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0318 | 0.5 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0078 | 0.067 | 0.0957 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.5 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0368 | 0.433 | 0.4253 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.5 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.1536 | 0.1422 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.067 | 0.5 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0078 | 0.067 | 0.1167 |
Trichomonas vaginalis | regulator of G protein signaling 5, rgs5, putative | 0.0078 | 0.067 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0078 | 0.067 | 0.0544 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Echinococcus granulosus | A kinase anchor protein 10 mitochondrial | 0.0078 | 0.067 | 0.116 |
Echinococcus multilocularis | regulator of G protein signaling 3 | 0.0078 | 0.067 | 0.0544 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0368 | 0.433 | 0.7538 |
Schistosoma mansoni | regulator of G protein signaling 17 19 20 (rgs17 19 20) | 0.0078 | 0.067 | 0.0957 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0649 | 1 |
Brugia malayi | A-kinase anchor protein 10, precursor | 0.0078 | 0.067 | 0.1167 |
Brugia malayi | PXA domain containing protein | 0.0078 | 0.067 | 0.1167 |
Echinococcus granulosus | expressed protein | 0.0078 | 0.067 | 0.116 |
Schistosoma mansoni | regulator of G protein signaling 3 rgs3 | 0.0078 | 0.067 | 0.0957 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0026 | 0.0019 | 0.0296 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0318 | 0.4744 |
Loa Loa (eye worm) | RGS-3 protein | 0.0078 | 0.067 | 0.1167 |
Echinococcus granulosus | Regulator of G protein signaling 20 | 0.0078 | 0.067 | 0.116 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0318 | 0.0187 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 1 |
Echinococcus granulosus | axis inhibition protein axin | 0.0078 | 0.067 | 0.116 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0078 | 0.067 | 0.1167 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.1536 | 0.2675 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0649 | 1 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0078 | 0.067 | 0.116 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Brugia malayi | regulator of G-protein signaling rgs-7 | 0.0078 | 0.067 | 0.1167 |
Schistosoma mansoni | axis inhibition protein axin | 0.0078 | 0.067 | 0.0957 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.1536 | 0.1422 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Schistosoma mansoni | axis inhibition protein axin | 0.0078 | 0.067 | 0.0957 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.067 | 0.5 |
Echinococcus multilocularis | regulator of G protein signaling | 0.0078 | 0.067 | 0.0544 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.0402 | 0.4762 | 0.829 |
Schistosoma mansoni | regulator of G protein signaling | 0.0078 | 0.067 | 0.0957 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0026 | 0.0019 | 0.0296 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.067 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.5 |
Schistosoma mansoni | regulator of G protein signaling | 0.0078 | 0.067 | 0.0957 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0318 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0649 | 0.113 |
Schistosoma mansoni | regulator of G protein signaling | 0.0078 | 0.067 | 0.0957 |
Schistosoma mansoni | regulator of G protein signaling | 0.0078 | 0.067 | 0.0957 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.048 | 0.5744 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0649 | 0.0523 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0402 | 0.4762 | 0.829 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.067 | 0.5 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.048 | 0.5744 | 1 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.029 | 0.3348 | 0.6945 |
Brugia malayi | Regulator of G protein signaling domain containing protein | 0.0078 | 0.067 | 0.1167 |
Entamoeba histolytica | hypothetical protein | 0.0078 | 0.067 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.067 | 0.1167 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0078 | 0.067 | 0.5 |
Loa Loa (eye worm) | PXA domain-containing protein | 0.0078 | 0.067 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0649 | 0.113 |
Echinococcus multilocularis | expressed protein | 0.0078 | 0.067 | 0.0544 |
Schistosoma mansoni | regulator of G protein signaling | 0.0078 | 0.067 | 0.0957 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.1536 | 0.3031 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0368 | 0.433 | 0.748 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0133 | 0.0232 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.0402 | 0.4762 | 0.4691 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0318 | 0.0399 |
Schistosoma mansoni | serine/threonine protein kinase | 0.048 | 0.5744 | 1 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.0402 | 0.4762 | 1 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0402 | 0.4762 | 0.829 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.