Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin b | 0.0606 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0234 | 0.1712 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0288 | 0.2933 | 0.2933 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0288 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | cysteine protease | 0.0288 | 0.2933 | 0.2205 |
Plasmodium vivax | vivapain-2 | 0.0288 | 0.2933 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0288 | 0.2933 | 0.2933 |
Brugia malayi | Cathepsin L-like precursor | 0.0288 | 0.2933 | 0.2933 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0288 | 0.2933 | 0.2933 |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0199 | 0.0933 | 0.3182 |
Onchocerca volvulus | Cathepsin L homolog | 0.0288 | 0.2933 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0288 | 0.2933 | 0.2205 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0199 | 0.0933 | 0.0933 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0199 | 0.0933 | 0.0933 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0288 | 0.2933 | 0.2933 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0199 | 0.0933 | 0.0933 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0288 | 0.2933 | 0.2933 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0288 | 0.2933 | 1 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0288 | 0.2933 | 0.2933 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0288 | 0.2933 | 0.2933 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0288 | 0.2933 | 0.2933 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0288 | 0.2933 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0234 | 0.1712 | 0.0859 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0199 | 0.0933 | 0.3182 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0288 | 0.2933 | 0.2933 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0234 | 0.1712 | 0.5836 |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0288 | 0.2933 | 0.2205 |
Brugia malayi | cathepsin L-like precursor | 0.0199 | 0.0933 | 0.0933 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0288 | 0.2933 | 0.2933 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0199 | 0.0933 | 0.0933 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0288 | 0.2933 | 0.2933 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0288 | 0.2933 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0288 | 0.2933 | 0.2933 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0234 | 0.1712 | 0.1712 |
Loa Loa (eye worm) | hypothetical protein | 0.0288 | 0.2933 | 0.2205 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0606 | 1 | 1 |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0234 | 0.1712 | 0.1712 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0288 | 0.2933 | 0.2205 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0288 | 0.2933 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0288 | 0.2933 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0288 | 0.2933 | 0.2933 |
Giardia lamblia | Cathepsin B precursor | 0.0234 | 0.1712 | 0.5 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0288 | 0.2933 | 0.2933 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0288 | 0.2933 | 0.2933 |
Giardia lamblia | Cathepsin B precursor | 0.0234 | 0.1712 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0199 | 0.0933 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0288 | 0.2933 | 0.2933 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0288 | 0.2933 | 0.2933 |
Leishmania major | cathepsin L-like protease | 0.0288 | 0.2933 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0606 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0606 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0606 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0288 | 0.2933 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0234 | 0.1712 | 0.5836 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0288 | 0.2933 | 0.2933 |
Onchocerca volvulus | 0.0288 | 0.2933 | 1 | |
Onchocerca volvulus | Cathepsin F homolog | 0.0288 | 0.2933 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0288 | 0.2933 | 0.2933 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0199 | 0.0933 | 0.0933 |
Loa Loa (eye worm) | ctsf protein | 0.0288 | 0.2933 | 0.2205 |
Leishmania major | cysteine peptidase A (CPA) | 0.0288 | 0.2933 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0288 | 0.2933 | 0.2933 |
Entamoeba histolytica | cysteine protease, putative | 0.0288 | 0.2933 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0199 | 0.0933 | 0.0933 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Echinococcus granulosus | cathepsin b | 0.0606 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0288 | 0.2933 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0606 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0288 | 0.2933 | 0.2933 |
Echinococcus multilocularis | cathepsin b | 0.0606 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0288 | 0.2933 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0288 | 0.2933 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | > 50 | 50% Cytostatic concentration required to inhibit human erythroleukemic (HEL) cell proliferartion | ChEMBL. | 9171871 |
EC50 (functional) | > 40 ug ml-1 | 50% effective concentration required to reduce cytomegalovirus (CMV AD-169 strain)-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 40 ug ml-1 | 50% effective concentration required to reduce cytomegalovirus (CMV Davis strain)-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 100 ug ml-1 | 50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK) VMW 1837 strain)-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 200 ug ml-1 | Effective concentration required to reduce sindbis virus-induced cytopathicity in vero cells | ChEMBL. | 9171871 |
EC50 (functional) | > 200 ug ml-1 | Effective concentration required to reduce coxsackie virus B4-induced cytopathicity in vero cells | ChEMBL. | 9171871 |
EC50 (functional) | > 200 ug ml-1 | Effective concentration required to reduce reovirus-1-induced cytopathicity in vero cells | ChEMBL. | 9171871 |
EC50 (functional) | > 400 ug ml-1 | 50% effective concentration required to reduce herpes simplex virus-1 (HSV-1 KOS strain)-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 400 ug ml-1 | 50% effective concentration required to reduce herpes simplex virus-2 (HSV-2 G strain)-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 400 ug ml-1 | 50% effective concentration required to reduce herpes simplex virus-1 (HSV- (TK) B2006 strain)-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 400 ug ml-1 | 50% effective concentration required to reduce vaccinia virus-induced cytopathicity | ChEMBL. | 9171871 |
EC50 (functional) | > 400 ug ml-1 | Effective concentration required to reduce vesicular stomatitis virus (VSV)-induced cytopathicity in vero cells | ChEMBL. | 9171871 |
EC50 (functional) | > 400 ug ml-1 | Effective concentration required to reduce parainfluenza-3-induced cytopathicity in vero cells | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against murine leukemia L1210 cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against murine mammary carcinoma FM3A cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against human lymphocyte Molt 4/clone 8 cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against human lymphocyte CEM cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against murine leukemia L1210 cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against murine mammary carcinoma FM3A cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against human lymphocyte Molt 4/clone 8 cell line | ChEMBL. | 9171871 |
IC50 (functional) | > 200 ug ml-1 | Cytostatic activity of the compound against human lymphocyte CEM cell line | ChEMBL. | 9171871 |
Inhibition (binding) | = 68.2 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 100.0 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 68.2 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 100.0 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 90.2 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 10.0 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 90.2 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 10.0 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 91 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 1.0 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 91 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 1.0 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 92.8 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 0.1 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 92.8 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 0.1 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 99.9 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 0.01 (microM) concentration | ChEMBL. | 9171871 |
Inhibition (binding) | = 99.9 % | Inhibition of human placental S-Adenosylhomocysteine hydrolase at 0.01 (microM) concentration | ChEMBL. | 9171871 |
MIC (functional) | > 400 | Minimum inhibitory concentration required to effect a microscopically visible change of cell morphology in human embryonic skin-muscle (E6SM) cell culture. | ChEMBL. | 9171871 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.