Detailed information for compound 588984

Basic information

Technical information
  • TDR Targets ID: 588984
  • Name: potassium benzenesulfonate
  • MW: 197.273 | Formula: C6H6KO3S
  • H donors: 0 H acceptors: 3 LogP: 0.59 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-]S(=O)(=O)c1ccccc1.[KH+]
  • InChi: 1S/C6H6O3S.K/c7-10(8,9)6-4-2-1-3-5-6;/h1-5H,(H,7,8,9);/q;+1/p-1
  • InChiKey: ABHHITAVUODQNA-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

  • potassium besylate
  • 934-55-4
  • EINECS 213-286-9
  • Potassium benzenesulphonate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi DNA polymerase delta catalytic subunit 0.0079 0.3861 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0079 0.3861 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.5976 0.8837
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.218 0.5462
Schistosoma mansoni hypothetical protein 0.0036 0.1151 0.1151
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0079 0.3861 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0026 0.0557 0.1442
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0156 0.0403
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0156 0.0403
Plasmodium vivax DNA polymerase alpha, putative 0.0026 0.0557 0.1442
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.218 0.5645
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0079 0.3861 0.3861
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0079 0.3861 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0156 0.0156
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0026 0.0557 0.1442
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.5976 0.8837
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0156 0.0156
Schistosoma mansoni hypothetical protein 0.0177 1 1
Mycobacterium tuberculosis Probable reductase 0.0113 0.5976 0.8837
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.2019 0.5027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.6763 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0074 0.3555 0.9205
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0079 0.3861 1
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0026 0.0557 0.1442
Echinococcus multilocularis geminin 0.0177 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0074 0.3555 0.3555
Plasmodium falciparum glutathione reductase 0.0049 0.2019 0.5228
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0026 0.0557 0.1442
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0074 0.3555 0.9205
Brugia malayi Thioredoxin reductase 0.0049 0.2019 0.5228
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0026 0.0557 0.1442
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0074 0.3555 0.3555
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.6763 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0074 0.3555 0.3555
Loa Loa (eye worm) hypothetical protein 0.0026 0.0557 0.1083
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0026 0.0557 0.1442
Entamoeba histolytica hypothetical protein 0.0038 0.128 0.3034
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0074 0.3555 0.9205
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.3555 0.9205
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0156 0.0403
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0026 0.0557 0.0557
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0156 0.0403
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0074 0.3555 0.9172
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0026 0.0557 0.0557
Schistosoma mansoni ap endonuclease 0.002 0.0156 0.0156
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0 0.5
Entamoeba histolytica hypothetical protein 0.0038 0.128 0.3034
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.1151 0.2982
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0156 1
Loa Loa (eye worm) glutathione reductase 0.0049 0.2019 0.5027
Leishmania major trypanothione reductase 0.0049 0.2019 0.5228
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.2019 0.2019
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0156 0.0403
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.2019 0.2019
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0156 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.6763 1
Plasmodium falciparum thioredoxin reductase 0.0049 0.2019 0.5228
Echinococcus granulosus ubiquitin specific protease 41 0.0074 0.3555 0.3555
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0079 0.3861 0.3861
Toxoplasma gondii DNA polymerase 0.0079 0.3861 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0074 0.3555 0.3555
Toxoplasma gondii thioredoxin reductase 0.0049 0.2019 0.5228
Schistosoma mansoni hypothetical protein 0.0177 1 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0074 0.3555 0.3555
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.128 0.128
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0079 0.3861 1
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0079 0.3861 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0074 0.3555 0.3555
Plasmodium vivax glutathione reductase, putative 0.0049 0.2019 0.5228
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0026 0.0557 0.0557
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0026 0.0557 0.1442
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0026 0.0557 0.1442
Brugia malayi hypothetical protein 0.0038 0.128 0.3315
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.3555 0.9205
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0064 0.2958 0.766
Entamoeba histolytica hypothetical protein 0.0038 0.128 0.3034
Trypanosoma brucei trypanothione reductase 0.0049 0.2019 0.5228
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0026 0.0557 0.1442
Trichomonas vaginalis conserved hypothetical protein 0.0074 0.3555 0.9205
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0026 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0052 0.218 0.5462
Brugia malayi DNA polymerase family B containing protein 0.0026 0.0557 0.1442
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0079 0.3861 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.6763 1
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0026 0.0557 0.1442
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0026 0.0557 0.1442
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0074 0.3555 0.9205
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0079 0.3861 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0156 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.218 0.5645
Entamoeba histolytica hypothetical protein 0.0038 0.128 0.3034
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.2019 0.5228
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0026 0.0557 0.1442
Schistosoma mansoni hypothetical protein 0.0038 0.128 0.128
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.128 0.128
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0156 0.0403
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.3555 0.9205
Toxoplasma gondii DNA polymerase family B protein 0.0026 0.0557 0.1442
Brugia malayi glutathione reductase 0.0049 0.2019 0.5228
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.128 0.128
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0026 0.0557 0.0557
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.2019 0.5228
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0026 0.0557 0.0557
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.5976 0.8837
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0026 0.0557 0.1442
Trichomonas vaginalis DNA polymerase II, putative 0.0026 0.0557 0.1442
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0079 0.3861 1
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0026 0.0557 0.1442
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0079 0.3861 0.3861
Brugia malayi DNA polymerase alpha catalytic subunit 0.0026 0.0557 0.1442
Toxoplasma gondii exonuclease III APE 0.002 0.0156 0.0403
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.3555 0.9172
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0074 0.3555 0.9205
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0026 0.0557 0.1442
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.5976 0.8837
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0156 0.0403
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0156 0.0403
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0026 0.0557 0.0557
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.2019 0.2985
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.0026 0.0557 0.1442
Loa Loa (eye worm) hypothetical protein 0.0036 0.1151 0.2687
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0079 0.3861 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0074 0.3555 0.3555
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0026 0.0557 0.0557
Schistosoma mansoni ap endonuclease 0.002 0.0156 0.0156
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0026 0.0557 0.0557
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.5976 0.8837
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0156 0.0403
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0156 0.0403

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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