Detailed information for compound 589372

Basic information

Technical information
  • TDR Targets ID: 589372
  • Name: 3,4-dichlorophenol
  • MW: 163.001 | Formula: C6H4Cl2O
  • H donors: 1 H acceptors: 1 LogP: 2.82 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C6H4Cl2O/c7-5-2-1-4(9)3-6(5)8/h1-3,9H
  • InChiKey: WDNBURPWRNALGP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 95-77-2
  • NSC 60648
  • C14462
  • 4,5-Dichlorophenol
  • NSC60648
  • Phenol, 3,4-dichloro-
  • InChI=1/C6H4Cl2O/c7-5-2-1-4(9)3-6(5)8/h1-3,9
  • 442375_SUPELCO
  • 36793_RIEDEL
  • NCGC00091625-01
  • D70406_ALDRICH
  • ZINC00388513
  • 4-06-00-00952 (Beilstein Handbook Reference)
  • BRN 1907693
  • CCRIS 5904
  • EINECS 202-450-5
  • HSDB 4247

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0021 0.0158 0.104
Echinococcus granulosus MAM 0.0016 0.0071 0.0071
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.008 0.008
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0187 0.2673 0.2673
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0182 0.2603 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0158 0.104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0158 0.0574
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0692 0.2359
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.008 0.1057 0.3943
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0378 0.7199
Leishmania major cathepsin L-like protease 0.0062 0.0773 0.2673
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0187 0.2673 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0378 0.07
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2471 0.2471
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0378 0.5
Brugia malayi SEA domain containing protein 0.0014 0.0054 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0158 0.0574
Onchocerca volvulus 0.0016 0.008 0.0261
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0378 0.1399
Onchocerca volvulus 0.0016 0.008 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0507 0.0507
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0378 0.0378
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0378 0.1147
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0378 0.0378
Brugia malayi hypothetical protein 0.0016 0.0073 0.0255
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Schistosoma mansoni coup transcription factor 0.0021 0.0158 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Trypanosoma cruzi GMP reductase 0.0187 0.2673 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0158 0.0158
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0102 0.1379 0.4501
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0102 0.1379 0.4501
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0187 0.2673 1
Onchocerca volvulus Cathepsin L homolog 0.0016 0.008 0.0261
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0378 0.0378
Onchocerca volvulus 0.0016 0.008 0.0261
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0158 0.0574
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0158 0.0158
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0378 0.0378
Trypanosoma cruzi GMP reductase 0.0187 0.2673 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0158 0.0158
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0024 0.0205 0.0749
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0158 0.0158
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0158 0.0158
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0158 0.104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0378 0.0378
Brugia malayi hypothetical protein 0.0043 0.0494 0.1834
Entamoeba histolytica hypothetical protein 0.0043 0.0494 1
Brugia malayi hypothetical protein 0.0016 0.0071 0.0246
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.008 0.008
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0158 0.0158
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0378 0.1147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0158 0.0574
Toxoplasma gondii IMP dehydrogenas 0.0187 0.2673 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0158 0.0158
Loa Loa (eye worm) ctsf protein 0.0016 0.008 0.0281
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0507 0.0507
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.008 0.008
Brugia malayi Protein kinase domain containing protein 0.0016 0.0071 0.0246
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0158 0.0158
Loa Loa (eye worm) hypothetical protein 0.0036 0.0378 0.1399
Brugia malayi Cathepsin L-like precursor 0.0016 0.008 0.0281
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0158 0.0574
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0773 0.2673
Schistosoma mansoni hypothetical protein 0.0043 0.0494 0.0494
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0773 0.2673
Schistosoma mansoni hypothetical protein 0.0014 0.0054 0.0054
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0494 0.0494
Leishmania major guanosine monophosphate reductase 0.0187 0.2673 1
Brugia malayi Cathepsin L-like precursor 0.0016 0.008 0.0281
Echinococcus granulosus cathepsin l1 0.0016 0.008 0.008
Onchocerca volvulus Putative GMP reductase 0.008 0.1057 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0158 0.0158
Brugia malayi nuclear receptor NHR-88 0.0021 0.0158 0.0574
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0507 0.1883
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0378 0.0378
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0158 0.0574
Brugia malayi Cathepsin L-like precursor 0.0016 0.008 0.0281
Echinococcus multilocularis cysteine protease 0.0016 0.008 0.008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0507 0.0507
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0378 0.115
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0005 0.0005
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0187 0.2673 1
Brugia malayi Inositol-1 0.0036 0.0378 0.1396
Entamoeba histolytica hypothetical protein 0.0043 0.0494 1
Leishmania major cathepsin L-like protease 0.0062 0.0773 0.2673
Echinococcus multilocularis MAM 0.0016 0.0071 0.0071
Brugia malayi Cathepsin L-like precursor 0.0016 0.008 0.0281
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0378 0.115
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0158 0.0158
Echinococcus granulosus geminin 0.0164 0.233 0.233
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.008 0.008
Brugia malayi Cathepsin L-like precursor 0.0016 0.008 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0158 0.0158
Trypanosoma brucei GMP reductase 0.0187 0.2673 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0158 0.0574
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0158 0.0158
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0158 0.0574
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0572 0.1898
Schistosoma mansoni hypothetical protein 0.0152 0.2146 0.2146
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0182 0.2603 0.9695
Echinococcus multilocularis cysteine protease 0.0016 0.008 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0205 0.0494
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0187 0.2673 1
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0158 0.0158
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.008 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0378 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0158 0.0158
Brugia malayi Muscle positioning protein 4 0.0014 0.0054 0.0183
Brugia malayi steroid hormone receptor 0.0021 0.0158 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0158 0.0574
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.008 0.0281
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0773 0.2673
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0158 0.0574
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0187 0.2673 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0187 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0378 0.9978
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0378 0.0378
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0158 0.0158
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0158 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0158 0.0574
Onchocerca volvulus 0.0016 0.0071 0.0166
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0005 0.0005
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0158 0.0158
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0205 0.0481
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.008 0.0281
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0187 0.2673 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0158 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Loa Loa (eye worm) TK/ALK protein kinase 0.0016 0.0071 0.0246
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0071
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0158 0.0158
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0158 0.0574
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0016 0.0071 0.0071
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0246
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.008 0.1057 0.3943
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0378 0.7183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0378 0.0378
Echinococcus multilocularis geminin 0.0164 0.233 0.233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0507 0.0507
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0507 0.0507
Leishmania major cathepsin L-like protease 0.0062 0.0773 0.2673
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0187 0.2673 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0378 0.0378
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.2146 0.2146
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0205 0.0494
Brugia malayi hypothetical protein 0.0024 0.0205 0.0749
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0246
Loa Loa (eye worm) hypothetical protein 0.0016 0.0071 0.0246
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0378 0.9978
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0183
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.2146 0.2146
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0494 0.0494
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.008 0.008
Loa Loa (eye worm) DOMON domain-containing protein 0.0014 0.0054 0.0183
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2471 0.2471
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0507 0.0507
Leishmania major hypothetical protein, conserved 0.0024 0.0205 0.0481
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.008 0.008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0164 0.233 0.233
Onchocerca volvulus 0.0016 0.008 0.0261
Onchocerca volvulus 0.0016 0.008 0.0261
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0378 0.115
Brugia malayi GMP reductase 0.008 0.1057 0.3943
Loa Loa (eye worm) GMP reductase 0.008 0.1057 0.3943
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0158 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0158 0.0574
Loa Loa (eye worm) inositol-1 0.0036 0.0378 0.1396
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0507 0.0507
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0378 0.9978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.008 0.008
Onchocerca volvulus Cathepsin L homolog 0.0016 0.008 0.0261
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0507 0.1883
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0378 1
Entamoeba histolytica hypothetical protein 0.0043 0.0494 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Loa Loa (eye worm) IMP dehydrogenase 1 0.0187 0.2673 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0205 0.0481
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0158 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0158 0.0574
Schistosoma mansoni inositol monophosphatase 0.0036 0.0378 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0158 0.0574
Onchocerca volvulus Cathepsin F homolog 0.0016 0.008 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0158 0.0574
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0158 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0158 0.0574
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0378 0.1147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Onchocerca volvulus 0.0016 0.008 0.0261
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0085 0.1127 0.3265
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0158 0.0158
Schistosoma mansoni hypothetical protein 0.0164 0.233 0.233
Brugia malayi nuclear hormone receptor 0.0021 0.0158 0.0574
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0158 0.0158
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0378 0.0703
Loa Loa (eye worm) cysteine protease 0.0016 0.008 0.0281
Entamoeba histolytica hypothetical protein 0.0043 0.0494 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0378 0.0378
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0773 0.2303
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0182 0.2603 1
Schistosoma mansoni microtubule-associated protein tau 0.0668 1 1
Onchocerca volvulus 0.0016 0.008 0.0261
Loa Loa (eye worm) fibroinase 0.0016 0.008 0.0281
Onchocerca volvulus 0.0016 0.0071 0.0166
Echinococcus multilocularis microtubule associated protein 2 0.0668 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0158 0.0158
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0378 0.0378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0158 0.0574
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0494 0.0494
Loa Loa (eye worm) hypothetical protein 0.0016 0.008 0.0281
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0158 0.0158
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0205 0.0481
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0158 0.0158
Brugia malayi Cathepsin L-like precursor 0.0016 0.008 0.0281
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0187 0.2673 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0183
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0378 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0187 0.2673 1
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0158 0.104
Brugia malayi ecdysteroid receptor 0.0021 0.0158 0.0574
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0085 0.1127 0.3428
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0158 0.0574
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0773 0.2673
Echinococcus multilocularis thyroid hormone receptor alpha 0.0173 0.2471 0.2471
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0378 0.1147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0158 0.0574
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0205 0.0494
Loa Loa (eye worm) hypothetical protein 0.0021 0.0158 0.0574
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0187 0.2673 0.2673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0158 0.0574
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0187 0.2673 0.2673

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.2213 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.2461 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.9665 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.1317 uM PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of estrogen receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.1632 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of androgen receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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