Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.1336 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0057 | 0.0057 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0162 | 0.0937 | 0.0937 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0162 | 0.0937 | 0.0937 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0059 | 0.0138 | 0.0138 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0048 | 0.0057 | 0.0057 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0162 | 0.0937 | 0.0937 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0802 | 0.5878 | 0.5878 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0802 | 0.5878 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0093 | 0.0158 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0048 | 0.0057 | 0.0057 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0802 | 0.5878 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0093 | 0.0158 |
Brugia malayi | Cytochrome P450 family protein | 0.006 | 0.0152 | 0.0152 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0343 | 0.2331 | 0.2331 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.018 | 0.1078 | 0.6343 |
Mycobacterium ulcerans | hypothetical protein | 0.018 | 0.1078 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1336 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0093 | 0.0093 |
Brugia malayi | MH2 domain containing protein | 0.0135 | 0.0731 | 0.0731 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0261 | 0.17 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0802 | 0.5878 | 0.5878 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0343 | 0.2331 | 0.2331 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0802 | 0.5878 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0093 | 0.0093 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0093 | 0.0158 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0093 | 0.0158 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0802 | 0.5878 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1336 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1336 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0111 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0683 | 0.4957 | 0.4957 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.006 | 0.0152 | 0.0152 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0093 | 0.0158 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0343 | 0.2331 | 0.2331 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0048 | 0.0057 | 0.0057 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0343 | 0.2331 | 0.2331 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0135 | 0.0731 | 0.0731 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0093 | 0.0158 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0093 | 0.0158 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0135 | 0.0731 | 0.0731 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 0 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 1.77 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 1.9 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 2.24 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 13 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 20 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 2.68 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -6 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 13 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 20 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 102 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.11 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.76869 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.