Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Methionine aminopeptidase MapB (map) (peptidase M) | 0.0029 | 0.422 | 0.5 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0029 | 0.422 | 0.422 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0029 | 0.422 | 0.5 |
Mycobacterium tuberculosis | Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) | 0.0029 | 0.422 | 0.5 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0029 | 0.422 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase | 0.0045 | 1 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0045 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0029 | 0.422 | 0.422 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0023 | 0.2295 | 0.5 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0045 | 1 | 1 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0045 | 1 | 1 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0029 | 0.422 | 1 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0045 | 1 | 1 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0045 | 1 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0029 | 0.422 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0045 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.0029 | 0.422 | 0.422 |
Schistosoma mansoni | methionyl aminopeptidase 1 (M24 family) | 0.0029 | 0.422 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0045 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0029 | 0.422 | 0.2499 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0029 | 0.422 | 0.422 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0045 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.2295 | 0.5 | |
Mycobacterium ulcerans | methionine aminopeptidase | 0.0029 | 0.422 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0029 | 0.422 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0023 | 0.2295 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0045 | 1 | 1 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0045 | 1 | 1 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0045 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0023 | 0.2295 | 0.5 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0029 | 0.422 | 0.5 |
Mycobacterium ulcerans | methionine aminopeptidase MapB | 0.0029 | 0.422 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 1 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 6.1 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 6.91 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 7.69 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
Inhibition (functional) | = 46 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition (functional) | = 100 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
Inhibition frequency index (IFI) (functional) | = 9.77 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 1 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 46 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.16 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
XC50 (functional) | = 0.6986 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.