Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0871 | 0.4506 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0252 | 0.0871 | 0.1567 |
Mycobacterium leprae | PROBABLE CONSERVED LIPOPROTEIN LPQI | 0.0228 | 0.0673 | 0.5 |
Trypanosoma cruzi | endo-beta-N-acetylglucosaminidase, putative | 0.0147 | 0 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0228 | 0.0673 | 0.3267 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.135 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.0224 | 0.0463 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0816 | 0.5561 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0871 | 0.4506 |
Leishmania major | glycosyl hydrolase-like protein | 0.0147 | 0 | 0.5 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0166 | 0.015 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0871 | 0.4506 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0228 | 0.0673 | 0.3267 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0871 | 0.4506 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0816 | 0.5561 | 1 |
Trypanosoma cruzi | endo-beta-N-acetylglucosaminidase, putative | 0.0147 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein LpqI | 0.0228 | 0.0673 | 0.5 |
Trichomonas vaginalis | beta-hexosaminidase, putative | 0.0228 | 0.0673 | 0.3267 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0358 | 0.1751 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0871 | 0.4506 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0358 | 0.1751 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.0224 | 0.0463 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.135 | 1 | 1 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0816 | 0.5561 | 1 |
Trypanosoma brucei | endo-beta-N-acetylglucosaminidase, putative | 0.0147 | 0 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0252 | 0.0871 | 0.4506 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0252 | 0.0871 | 0.1567 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 6.86 | Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter | ChEMBL. | 11931612 |
Log 1/C (binding) | = 6.86 | Inhibition of [3H]-dopamine uptake in HEK293 cells expressing recombinant Dopamine transporter | ChEMBL. | 11931612 |
pKD (binding) | = 7.14 | Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 8.29 | Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 7.14 | Inhibition of [125I]-RTI-55 binding to human SERT in clonal cells | ChEMBL. | 11931612 |
pKD (binding) | = 8.29 | Inhibition of radioligand [125I]-RTI-55 binding to human Dopamine transporter in clonal cells | ChEMBL. | 11931612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.