Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | References | |
Homo sapiens | protease, serine, 2 (trypsin 2) | References | |
Homo sapiens | protease, serine, 3 | Starlite/ChEMBL | References |
Homo sapiens | tryptase gamma 1 | References | |
Homo sapiens | tryptase delta 1 | Starlite/ChEMBL | References |
Homo sapiens | tryptase alpha/beta 1 | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | tryptase gamma 1 | 321 aa | 334 aa | 26.9 % |
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 3 | 261 aa | 234 aa | 25.2 % |
Schistosoma mansoni | cercarial elastase (S01 family) | protease, serine, 2 (trypsin 2) | 247 aa | 240 aa | 25.8 % |
Brugia malayi | Trypsin family protein | tryptase alpha/beta 1 | 275 aa | 288 aa | 25.4 % |
Brugia malayi | Trypsin family protein | tryptase delta 1 | 242 aa | 204 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | phosphatidylinositol 4,5 bisphosphate 3 kinase | 0.1466 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0371 | 0.0698 | 0.0471 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.1466 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0614 | 0.2763 | 0.3306 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.0698 | 0.0836 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0947 | 0.5595 | 1 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0919 | 0.5357 | 0.9555 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0614 | 0.2763 | 0.0005 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0947 | 0.5595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.0698 | 0.0836 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0457 | 0.143 | 0.5 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0947 | 0.5595 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0614 | 0.2763 | 0.4713 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0614 | 0.2759 | 0.4706 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0947 | 0.5595 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0754 | 0.3951 | 0.6931 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0317 | 0.0238 | 0.0426 |
Onchocerca volvulus | 0.0371 | 0.0698 | 1 | |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0651 | 0.3074 | 0.5294 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0651 | 0.3074 | 0.5294 |
Brugia malayi | Protein kinase domain containing protein | 0.0614 | 0.2763 | 0.4713 |
Trichomonas vaginalis | AGC family protein kinase | 0.0614 | 0.2763 | 0.4713 |
Trichomonas vaginalis | AGC family protein kinase | 0.0614 | 0.2763 | 0.4713 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0614 | 0.2763 | 0.2586 |
Brugia malayi | Trypsin family protein | 0.0371 | 0.0698 | 0.0859 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0371 | 0.0698 | 0.0471 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.042 | 0.1115 | 0.1637 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0519 | 0.1951 | 0.3197 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0754 | 0.3951 | 0.6931 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0614 | 0.2763 | 0.4713 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.1273 | 0.8356 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0947 | 0.5595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0334 | 0.0382 | 0.0457 |
Trichomonas vaginalis | AGC family protein kinase | 0.0614 | 0.2763 | 0.4713 |
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0947 | 0.5595 | 1 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0614 | 0.2763 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0614 | 0.2759 | 0.3302 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0317 | 0.0238 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0947 | 0.5595 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0614 | 0.2763 | 0.3306 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.00085 uM | Inhibition of Tryptase in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 0.00085 uM | Inhibition of Tryptase in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 4.67 uM | Inhibition of trypsin in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 4.67 uM | Inhibition of trypsin in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 20.8 uM | Inhibition of thrombin in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 20.8 uM | Inhibition of thrombin in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 62.2 uM | Inhibition plasmin in human mast cells | ChEMBL. | 11425524 |
Ki (binding) | = 62.2 uM | Inhibition plasmin in human mast cells | ChEMBL. | 11425524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.