Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Dopamine receptor | 475 aa | 405 aa | 33.3 % |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Dopamine receptor | 475 aa | 398 aa | 34.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.03 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.03 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.03 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.03 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | 0.03 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | 0.03 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.03 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.03 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | 0.03 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.03 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.03 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.03 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 71 mg kg-1 | Suppression of conditional avoidance after peroral administration | ChEMBL. | 2875184 |
IC50 (binding) | > 10 uM | Binding affinity for dopamine receptor in rat striatal membrane using [3H]-haloperidol as radioligand | ChEMBL. | 2875184 |
IC50 (binding) | > 10 uM | Binding affinity for dopamine receptor in rat striatal membrane using [3H]-haloperidol as radioligand | ChEMBL. | 2875184 |
MED (functional) | = 100 mg kg-1 | Ability to inhibit locomotor activity using ataxia test. | ChEMBL. | 2875184 |
MED (functional) | = 100 mg kg-1 | Ability to inhibit locomotor activity using ataxia test. | ChEMBL. | 2875184 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.