TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 322.318 | Formula: C17H14N4O3
H donors: 1 H acceptors: 3 LogP: 3.61 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc2c(c1)nccc2NN=Cc1cccc(c1)N(=O)=O
InChi: 1S/C17H14N4O3/c1-24-14-5-6-15-16(7-8-18-17(15)10-14)20-19-11-12-3-2-4-13(9-12)21(22)23/h2-11H,1H3,(H,18,20)
InChiKey: CISBMECUZMVLQO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0225	0.0225
Schistosoma mansoni	metabotropic glutamate receptor	0.0158	0.1502	0.1502
Echinococcus granulosus	tyrosine kinase	0.003	0.013	0.013
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0061	0.0061
Echinococcus granulosus	nmda type glutamate receptor	0.003	0.013	0.013
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.0947	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0296	0.0296
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0296	0.0296
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0039	0.0225	0.0225
Brugia malayi	PHD-finger family protein	0.002	0.002	0.002
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0564	0.0564
Echinococcus multilocularis	rho associated protein kinase	0.0142	0.1326	0.1326
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0197	0.0197
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Brugia malayi	jmjC domain containing protein	0.0071	0.0564	0.0564
Schistosoma mansoni	hypothetical protein	0.0019	0.0003	0.0003
Echinococcus granulosus	Niemann Pick C1 protein	0.0143	0.1346	0.1346
Echinococcus granulosus	peregrin	0.0057	0.0416	0.0416
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0053	0.0368	0.0368
Echinococcus granulosus	atrial natriuretic peptide receptor	0.003	0.013	0.013
Onchocerca volvulus		0.003	0.013	0.0541
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0368	0.3768	0.3768
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0039	0.0225	0.0225
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0057	0.0416	0.0416
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0296	0.0296
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.0947	1	1
Echinococcus granulosus	glutamate receptor 2	0.003	0.013	0.013
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.0899	0.0899
Echinococcus granulosus	dnaJ subfamily B	0.0417	0.4293	0.4293
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0271	0.2724	0.2724
Echinococcus granulosus	expressed conserved protein	0.0094	0.0817	0.0817
Toxoplasma gondii	AGC kinase	0.0039	0.0225	0.0225
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0265	0.0265
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0061	0.0061
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0061	0.0061
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.0947	1	1
Echinococcus multilocularis	glutamate receptor 2	0.003	0.013	0.013
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0039	0.0225	0.0225
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0039	0.0225	0.0225
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.0883	0.0883
Entamoeba histolytica	hypothetical protein	0.0037	0.0197	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0053	0.037	0.037
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.0947	1	1
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Plasmodium vivax	protein-S-isoprenylcysteine O-methyltransferase, putative	0.0947	1	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.003	0.013	0.013
Echinococcus granulosus	cpg binding protein	0.0031	0.0135	0.0135
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0019	0.0003	0.0003
Onchocerca volvulus	Poor gastrulation protein homolog	0.0053	0.0368	0.2425
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0061	0.0061
Echinococcus multilocularis	glutamate receptor 2	0.003	0.013	0.013
Loa Loa (eye worm)	protein-S isoprenylcysteine O-methyltransferase	0.0947	1	1
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.0883	0.0826
Loa Loa (eye worm)	hypothetical protein	0.002	0.002	0.002
Leishmania major	protein kinase A catalytic subunit	0.0039	0.0225	0.0225
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0225	0.0225
Brugia malayi	CHE-14 protein	0.0043	0.0265	0.0265
Schistosoma mansoni	serine/threonine protein kinase	0.0142	0.1326	0.1326
Schistosoma mansoni	hypothetical protein	0.0172	0.1657	0.1657
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0039	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0265	0.0265
Mycobacterium ulcerans	hypothetical protein	0.0414	0.4254	1
Echinococcus multilocularis		0.0947	1	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.0416	0.0416
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0039	0.0225	0.0225
Echinococcus multilocularis	expressed conserved protein	0.0094	0.0817	0.0817
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Echinococcus multilocularis	dnaJ subfamily B	0.0417	0.4293	0.4293
Trypanosoma brucei	prenyl protein specific carboxyl methyltransferase	0.0947	1	1
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0039	0.0225	0.0225
Toxoplasma gondii	AGC kinase	0.0039	0.0225	0.0225
Trypanosoma cruzi	prenyl protein specific carboxyl methyltransferase, putative	0.0947	1	1
Brugia malayi	jmjC domain containing protein	0.0187	0.1815	0.1815
Schistosoma mansoni	metabotropic glutamate receptor	0.0271	0.2724	0.2724
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0083	0.0696	0.0696
Entamoeba histolytica	hypothetical protein	0.003	0.013	0.0069
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0296	0.0296
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.003	0.013	0.013
Onchocerca volvulus		0.0142	0.1326	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.0883	0.0883
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.002	0.0022	0.0022
Schistosoma mansoni	cpg binding protein	0.0031	0.0135	0.0135
Echinococcus granulosus	GPCR family 3 C terminal	0.0053	0.0368	0.0368
Plasmodium falciparum	phd finger protein, putative	0.0057	0.0416	0.0416
Onchocerca volvulus	Alhambra homolog	0.0057	0.0416	0.2809
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0265	0.0265
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0197	0.0197
Echinococcus granulosus	rho-associated protein kinase 1	0.0142	0.1326	0.1326
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.003	0.013	0.013
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.003	0.013	0.013
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Schistosoma mansoni	glutamate receptor NMDA	0.003	0.013	0.013
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.003	0.013	0.0541
Giardia lamblia	PHD finger protein 15	0.0057	0.0416	0.0196
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.003	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0417	0.4293	0.4293
Echinococcus multilocularis	receptor type guanylyl cyclase	0.003	0.013	0.013
Brugia malayi	PHD-finger family protein	0.0057	0.0416	0.0416
Trichomonas vaginalis	protein-S isoprenylcysteine O-methyltransferase, putative	0.0947	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0197	0.0197
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.002	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0296	0.0296
Brugia malayi	hypothetical protein	0.003	0.013	0.013
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0061	0.0061
Echinococcus multilocularis	jumonji domain containing protein	0.0079	0.0657	0.0657
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.002	0.0018	0.0018
Echinococcus granulosus	lysine specific demethylase 5A	0.0071	0.0564	0.0564
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0061	0.5
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.013	0.013
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0265	0.0041
Brugia malayi	Bromodomain containing protein	0.0057	0.0416	0.0416
Plasmodium falciparum	protein-S-isoprenylcysteine O-methyltransferase, putative	0.0947	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0039	0.0225	0.0165
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0039	0.0225	0.0225
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0296	0.0296
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0039	0.0217	0.0217
Onchocerca volvulus		0.003	0.013	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0856	0.0856
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.003	0.013	0.013
Echinococcus multilocularis	Niemann Pick C1 protein	0.0143	0.1346	0.1346
Toxoplasma gondii	PHD-finger domain-containing protein	0.0057	0.0416	0.0416
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	0.0439	0.4527	0.4527
Schistosoma mansoni	hypothetical protein	0.0042	0.0249	0.0249
Trypanosoma cruzi	extracellular receptor, putative	0.003	0.013	0.013
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0039	0.0225	0.0225
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0416	0.0416
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0039	0.0225	0.0225
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0061	0.5
Schistosoma mansoni	hypothetical protein	0.0057	0.0416	0.0416
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0296	0.0296
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.0883	0.0883
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0057	0.0416	0.0416
Schistosoma mansoni	hypothetical protein	0.0037	0.0197	0.0197
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0187	0.1815	0.1815
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.003	0.013	0.013
Schistosoma mansoni	cpg binding protein	0.0031	0.0135	0.0135
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0039	0.0217	0.0217
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0399	0.4096	0.4096
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.003	0.013	0.013
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.003	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0042	0.0249	0.0249
Schistosoma mansoni	tyrosine kinase	0.003	0.013	0.013
Entamoeba histolytica	prenyl cysteine carboxyl methyltransferase, putative	0.0947	1	1
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0003	0.0003
Schistosoma mansoni	tyrosine kinase	0.003	0.013	0.013
Giardia lamblia	Isoprenylcysteine carboxyl methyltransferase	0.0947	1	1
Mycobacterium tuberculosis	Conserved hypothetical membrane protein	0.0414	0.4254	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.047	0.047
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0039	0.0225	0.0225
Echinococcus multilocularis	nmda type glutamate receptor	0.003	0.013	0.013
Echinococcus granulosus	PHD finger protein rhinoceros	0.0057	0.0416	0.0416
Leishmania major	prenyl protein specific carboxyl methyltransferase, putative	0.0947	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0061	0.0061
Brugia malayi	F/Y-rich N-terminus family protein	0.0028	0.0099	0.0099
Schistosoma mansoni	protein-s-isoprenylcysteine o-methyltransferase	0.0947	1	1
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0039	0.0225	0.0225
Schistosoma mansoni	serine/threonine protein kinase	0.0039	0.0225	0.0225
Echinococcus granulosus	protein S isoprenylcysteine O methyltransferase	0.0947	1	1
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0039	0.0225	0.0225
Brugia malayi	hypothetical protein	0.0037	0.0197	0.0197
Brugia malayi	Protein kinase domain containing protein	0.0439	0.4527	0.4527
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0296	0.0296
Toxoplasma gondii	PHD-finger domain-containing protein	0.0019	0.0003	0.0003
Echinococcus granulosus	glutamate receptor 2	0.003	0.013	0.013
Schistosoma mansoni	patched 1	0.0043	0.0265	0.0265
Schistosoma mansoni	jumonji domain containing protein	0.0149	0.1401	0.1401
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0368	0.0368
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0039	0.0225	0.0225
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0399	0.4096	0.4096
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0187	0.1815	0.1815
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0225	0.0225
Onchocerca volvulus		0.0141	0.1318	0.9937
Leishmania major	extracellular receptor, putative	0.003	0.013	0.013
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0825	0.868	0.868
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0265	0.0265
Onchocerca volvulus		0.0029	0.0117	0.0441
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0061	0.0061
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0026	0.0081	0.0081
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.003	0.013	0.013
Entamoeba histolytica	hypothetical protein	0.0037	0.0197	0.0136
Echinococcus multilocularis	tyrosine kinase	0.003	0.013	0.013
Echinococcus multilocularis	cpg binding protein	0.0031	0.0135	0.0135
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0399	0.0399
Entamoeba histolytica	hypothetical protein	0.0037	0.0197	0.0136
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0071	0.0564	0.0564
Loa Loa (eye worm)	glutamate receptor	0.0324	0.329	0.329
Brugia malayi	Receptor family ligand binding region containing protein	0.0083	0.0696	0.0696
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0296	0.0296
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0271	0.2724	0.2724
Toxoplasma gondii	isoprenylcysteine carboxyl methyltransferase (icmt) family protein	0.0947	1	1
Echinococcus multilocularis	peregrin	0.0057	0.0416	0.0416
Loa Loa (eye worm)	jmjC domain-containing protein	0.0118	0.1071	0.1071
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0039	0.0225	0.0225
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.003	0.013	0.013
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.01	0.0883	0.0883
Echinococcus granulosus	geminin	0.0172	0.1657	0.1657
Echinococcus multilocularis	protein patched	0.0043	0.0265	0.0265
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0061	0.0061
Brugia malayi	Receptor family ligand binding region containing protein	0.003	0.013	0.013
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Echinococcus granulosus	jumonji domain containing protein	0.0079	0.0657	0.0657
Schistosoma mansoni	hypothetical protein	0.0042	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0399	0.4096	0.4096
Loa Loa (eye worm)	RGC/RGC protein kinase	0.003	0.013	0.013
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0324	0.329	0.329
Brugia malayi	Guanylyl cyclase protein 23	0.003	0.013	0.013
Schistosoma mansoni	cpg binding protein	0.0029	0.0117	0.0117
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0117	0.0117
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0022	0.0022
Schistosoma mansoni	hypothetical protein	0.0042	0.0249	0.0249
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0265	0.0265
Loa Loa (eye worm)	PHD-finger family protein	0.0057	0.0416	0.0416
Brugia malayi	AF-10 protein	0.0019	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0061	0.0061
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0294	0.2962	0.2962
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0053	0.0368	0.2425
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0019	0.0003	0.0003
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0053	0.0368	0.0368
Brugia malayi	metabotropic glutamate receptor type 2	0.0158	0.1502	0.1502
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.0564	0.0564
Schistosoma mansoni	hypothetical protein	0.0053	0.0368	0.0368
Entamoeba histolytica	hypothetical protein	0.0037	0.0197	0.0136
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0039	0.0225	0.0165
Echinococcus multilocularis	lysine specific demethylase 5A	0.0069	0.0546	0.0546
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0331	0.0331
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0083	0.0696	0.0696
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Schistosoma mansoni	protein kinase	0.003	0.013	0.013
Plasmodium vivax	hypothetical protein, conserved	0.0057	0.0416	0.0416
Loa Loa (eye worm)	hypothetical protein	0.003	0.013	0.013
Loa Loa (eye worm)	glutamate receptor	0.0127	0.1174	0.1174
Echinococcus multilocularis	geminin	0.0172	0.1657	0.1657
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.003	0.013	0.013
Schistosoma mansoni	hypothetical protein	0.0172	0.1657	0.1657

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition frequency index (IFI) (functional)	= 1.44	Inhibition Frequency Index (IFI)	GSK.	20485427
Percent growth inhibition (functional)	= -10 %	Percent inhibition of HepG2 growth (at 10 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 5 %	Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 99 %	Percent inhibition of P. falciparum Dd2 growth (at 2 uM)	GSK.	20485427
Percent growth inhibition (functional)	= 101 %	Percent inhibition of P. falciparum 3D7 growth (at 2 uM)	GSK.	20485427
XC50 (functional)	= 6.07	XC50 determination of P. falciparum 3D7 growth	GSK.	20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 603193