Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0039 | 0.0225 | 0.0225 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0296 | 0.0296 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0271 | 0.2724 | 0.2724 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0061 | 0.0061 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.0399 | 0.0399 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0057 | 0.0416 | 0.0416 |
Brugia malayi | Protein kinase domain containing protein | 0.0439 | 0.4527 | 0.4527 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0053 | 0.0368 | 0.0368 |
Echinococcus granulosus | peregrin | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Plasmodium vivax | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0019 | 0.0003 | 0.0003 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0331 | 0.0331 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 0.0696 | 0.0696 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0564 | 0.0564 |
Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.0019 | 0.0003 | 0.0003 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0039 | 0.0225 | 0.0225 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0061 | 0.0061 |
Toxoplasma gondii | AGC kinase | 0.0039 | 0.0225 | 0.0225 |
Plasmodium vivax | hypothetical protein, conserved | 0.002 | 0.0022 | 0.0022 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Onchocerca volvulus | Alhambra homolog | 0.0057 | 0.0416 | 0.2809 |
Toxoplasma gondii | isoprenylcysteine carboxyl methyltransferase (icmt) family protein | 0.0947 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0026 | 0.0081 | 0.0081 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.003 | 0.013 | 0.013 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0061 | 0.0061 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0028 | 0.0099 | 0.0099 |
Onchocerca volvulus | 0.0029 | 0.0117 | 0.0441 | |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.0083 | 0.0696 | 0.0696 |
Echinococcus granulosus | protein S isoprenylcysteine O methyltransferase | 0.0947 | 1 | 1 |
Giardia lamblia | Isoprenylcysteine carboxyl methyltransferase | 0.0947 | 1 | 1 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.003 | 0.013 | 0.013 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0061 | 0.0061 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0296 | 0.0296 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0143 | 0.1346 | 0.1346 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0158 | 0.1502 | 0.1502 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.002 | 0.0018 | 0.0018 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0143 | 0.1346 | 0.1346 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1657 | 0.1657 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.01 | 0.0883 | 0.0883 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0197 | 0.0197 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0417 | 0.4293 | 0.4293 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0271 | 0.2724 | 0.2724 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.0083 | 0.0696 | 0.0696 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0296 | 0.0296 |
Mycobacterium ulcerans | hypothetical protein | 0.0414 | 0.4254 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Brugia malayi | AF-10 protein | 0.0019 | 0.0003 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.0197 | 0.0197 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.047 | 0.047 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0061 | 0.0061 |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0296 | 0.0296 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0564 | 0.0564 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0197 | 0.0197 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0439 | 0.4527 | 0.4527 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0039 | 0.0217 | 0.0217 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0079 | 0.0657 | 0.0657 |
Plasmodium vivax | hypothetical protein, conserved | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Trypanosoma cruzi | extracellular receptor, putative | 0.003 | 0.013 | 0.013 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0265 | 0.0265 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0225 | 0.0225 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0296 | 0.0296 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0061 | 0.0061 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0265 | 0.0265 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.003 | 0.013 | 0.013 |
Brugia malayi | PHD-finger family protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0142 | 0.1326 | 0.1326 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Toxoplasma gondii | AGC kinase | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.0368 | 0.0368 |
Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.0019 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0856 | 0.0856 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0265 | 0.0265 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0265 | 0.0265 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0142 | 0.1326 | 0.1326 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0039 | 0.0225 | 0.0225 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0296 | 0.0296 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0399 | 0.4096 | 0.4096 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0118 | 0.1071 | 0.1071 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0249 | 0.0249 |
Echinococcus granulosus | expressed conserved protein | 0.0094 | 0.0817 | 0.0817 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0368 | 0.3768 | 0.3768 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0053 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | protein-S isoprenylcysteine O-methyltransferase | 0.0947 | 1 | 1 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | jumonji domain containing protein | 0.0149 | 0.1401 | 0.1401 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0265 | 0.0265 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0039 | 0.0225 | 0.0225 |
Echinococcus granulosus | jumonji domain containing protein | 0.0079 | 0.0657 | 0.0657 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0296 | 0.0296 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0271 | 0.2724 | 0.2724 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0368 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Brugia malayi | hypothetical protein | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0057 | 0.0416 | 0.0416 |
Giardia lamblia | PHD finger protein 15 | 0.0057 | 0.0416 | 0.0196 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0564 | 0.0564 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0296 | 0.0296 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0003 | 0.0003 |
Leishmania major | extracellular receptor, putative | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0265 | 0.0265 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0197 | 0.0197 |
Leishmania major | prenyl protein specific carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0057 | 0.0416 | 0.0416 |
Schistosoma mansoni | protein-s-isoprenylcysteine o-methyltransferase | 0.0947 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0399 | 0.4096 | 0.4096 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0416 | 0.0416 |
Brugia malayi | PHD-finger family protein | 0.002 | 0.002 | 0.002 |
Echinococcus multilocularis | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Brugia malayi | Guanylyl cyclase protein 23 | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0265 | 0.0041 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0187 | 0.1815 | 0.1815 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0083 | 0.0696 | 0.0696 |
Loa Loa (eye worm) | glutamate receptor | 0.0324 | 0.329 | 0.329 |
Echinococcus multilocularis | peregrin | 0.0057 | 0.0416 | 0.0416 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0061 | 0.0061 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0061 | 0.5 |
Onchocerca volvulus | 0.0142 | 0.1326 | 1 | |
Brugia malayi | Receptor family ligand binding region containing protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0225 | 0.0225 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.003 | 0.013 | 0.013 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | protein kinase | 0.003 | 0.013 | 0.013 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0117 | 0.0117 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0117 | 0.0117 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.013 | 0.013 |
Trypanosoma brucei | prenyl protein specific carboxyl methyltransferase | 0.0947 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0039 | 0.0225 | 0.0165 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0294 | 0.2962 | 0.2962 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0069 | 0.0546 | 0.0546 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0019 | 0.0003 | 0.0003 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.0197 | 0.0197 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0053 | 0.0368 | 0.2425 |
Plasmodium falciparum | protein-S-isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus multilocularis | geminin | 0.0172 | 0.1657 | 0.1657 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0039 | 0.0225 | 0.0225 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0039 | 0.0225 | 0.0225 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Mycobacterium tuberculosis | Conserved hypothetical membrane protein | 0.0414 | 0.4254 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0265 | 0.0265 |
Brugia malayi | Bromodomain containing protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | glutamate receptor 2 | 0.003 | 0.013 | 0.013 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.0564 | 0.0564 |
Echinococcus granulosus | nmda type glutamate receptor | 0.003 | 0.013 | 0.013 |
Onchocerca volvulus | 0.003 | 0.013 | 0.0541 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.01 | 0.0883 | 0.0883 |
Echinococcus multilocularis | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0053 | 0.0368 | 0.2425 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0296 | 0.0296 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Echinococcus granulosus | geminin | 0.0172 | 0.1657 | 0.1657 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0158 | 0.1502 | 0.1502 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0135 | 0.0135 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.1657 | 0.1657 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.01 | 0.0883 | 0.0826 |
Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.002 | 0.0018 | 0.0018 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0053 | 0.0368 | 0.0368 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0187 | 0.1815 | 0.1815 |
Schistosoma mansoni | hypothetical protein | 0.0417 | 0.4293 | 0.4293 |
Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.002 | 0.0022 | 0.0022 |
Echinococcus granulosus | dnaJ subfamily B | 0.0417 | 0.4293 | 0.4293 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0039 | 0.0225 | 0.0225 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0057 | 0.0416 | 0.0416 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0825 | 0.868 | 0.868 |
Entamoeba histolytica | prenyl cysteine carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0061 | 0.5 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0399 | 0.4096 | 0.4096 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0225 | 0.0225 |
Echinococcus multilocularis | expressed conserved protein | 0.0094 | 0.0817 | 0.0817 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.037 | 0.037 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0117 | 0.0117 |
Echinococcus multilocularis | rho associated protein kinase | 0.0142 | 0.1326 | 0.1326 |
Schistosoma mansoni | glutamate receptor NMDA | 0.003 | 0.013 | 0.013 |
Trichomonas vaginalis | protein-S isoprenylcysteine O-methyltransferase, putative | 0.0947 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.003 | 0.013 | 0.0069 |
Trypanosoma cruzi | prenyl protein specific carboxyl methyltransferase, putative | 0.0947 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0057 | 0.0416 | 0.0416 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0324 | 0.329 | 0.329 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0039 | 0.0217 | 0.0217 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0039 | 0.0225 | 0.0165 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0039 | 0.0225 | 0.0225 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.01 | 0.0883 | 0.0883 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.003 | 0.013 | 0.0541 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0197 | 0.0136 |
Leishmania major | protein kinase A catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.0899 | 0.0899 |
Onchocerca volvulus | 0.003 | 0.013 | 0.0541 | |
Plasmodium falciparum | phd finger protein, putative | 0.0057 | 0.0416 | 0.0416 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.0883 | 0.0883 |
Echinococcus multilocularis | 0.0947 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.002 | 0.002 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0039 | 0.0225 | 0.0225 |
Schistosoma mansoni | tyrosine kinase | 0.003 | 0.013 | 0.013 |
Loa Loa (eye worm) | glutamate receptor | 0.0127 | 0.1174 | 0.1174 |
Brugia malayi | jmjC domain containing protein | 0.0187 | 0.1815 | 0.1815 |
Onchocerca volvulus | 0.0141 | 0.1318 | 0.9937 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition frequency index (IFI) (functional) | = 1.44 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
Percent growth inhibition (functional) | = -10 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 5 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 99 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
Percent growth inhibition (functional) | = 101 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
XC50 (functional) | = 6.07 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.