Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | pyruvate kinase 2, putative | 0.00107725 | 0.00935525 | 0.207672 |
Schistosoma mansoni | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Leishmania major | pyruvate kinase | 0.00219369 | 0.0450481 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.00152879 | 0.023791 | 0.024333 |
Leishmania major | pyruvate kinase | 0.00219369 | 0.0450481 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0460745 |
Loa Loa (eye worm) | hypothetical protein | 0.00219369 | 0.0450481 | 0.0450481 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.00219369 | 0.0450481 | 0.0450481 |
Echinococcus granulosus | zinc finger protein | 0.00152879 | 0.023791 | 0.024333 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.00219369 | 0.0450481 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.00219369 | 0.0450481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00152879 | 0.023791 | 0.023791 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.00219369 | 0.0450481 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.00219369 | 0.0450481 | 1 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.00219369 | 0.0450481 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyKII | 0.00107725 | 0.00935525 | 0.207672 |
Giardia lamblia | Pyruvate kinase | 0.00219369 | 0.0450481 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0460745 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.00152879 | 0.023791 | 0.024333 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.00219369 | 0.0450481 | 0.0450481 |
Schistosoma mansoni | zinc finger protein | 0.00152879 | 0.023791 | 0.024333 |
Echinococcus multilocularis | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0460745 |
Loa Loa (eye worm) | hypothetical protein | 0.00154883 | 0.0244318 | 0.0244318 |
Entamoeba histolytica | pyruvate kinase, putative | 0.00154883 | 0.0244318 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0320638 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.00219369 | 0.0450481 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0460745 |
Echinococcus granulosus | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.00219369 | 0.0450481 | 0.0450481 |
Loa Loa (eye worm) | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0450481 |
Schistosoma mansoni | bromodomain containing protein | 0.00152879 | 0.023791 | 0.024333 |
Echinococcus multilocularis | zinc finger protein | 0.00152879 | 0.023791 | 0.024333 |
Mycobacterium ulcerans | pyruvate kinase | 0.00219369 | 0.0450481 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Plasmodium falciparum | pyruvate kinase 2 | 0.00107725 | 0.00935525 | 0.207672 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.00219369 | 0.0450481 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.00176131 | 0.0312247 | 0.0319361 |
Loa Loa (eye worm) | hypothetical protein | 0.0320638 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.00152879 | 0.023791 | 0.024333 |
Loa Loa (eye worm) | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0450481 |
Loa Loa (eye worm) | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0450481 |
Brugia malayi | Bromodomain containing protein | 0.00152879 | 0.023791 | 0.023791 |
Echinococcus multilocularis | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0460745 |
Trypanosoma brucei | pyruvate kinase 1 | 0.00219369 | 0.0450481 | 1 |
Echinococcus granulosus | E3 ubiquitin protein ligase TRIM33 | 0.0313671 | 0.977724 | 1 |
Brugia malayi | PHD-finger family protein | 0.00152879 | 0.023791 | 0.023791 |
Plasmodium vivax | pyruvate kinase, putative | 0.00219369 | 0.0450481 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.00219369 | 0.0450481 | 0.0450481 |
Echinococcus granulosus | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Schistosoma mansoni | pyruvate kinase | 0.00219369 | 0.0450481 | 0.0460745 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.00154883 | 0.0244318 | 0.0244318 |
Chlamydia trachomatis | pyruvate kinase | 0.00219369 | 0.0450481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00152879 | 0.023791 | 0.023791 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.00219369 | 0.0450481 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.00219369 | 0.0450481 | 0.0450481 |
Echinococcus granulosus | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.00219369 | 0.0450481 | 1 |
Onchocerca volvulus | 0.0320638 | 1 | 1 | |
Echinococcus multilocularis | E3 ubiquitin protein ligase TRIM33 | 0.0313671 | 0.977724 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.00107725 | 0.00935525 | 0.00956839 |
Schistosoma mansoni | transcription intermediary factor 1-related | 0.0313671 | 0.977724 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 100 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 100 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 2.934 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 2.934 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | > 9.84 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | > 9.84 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.