Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0191705 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.00288202 | 0.0284555 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 7 | 0.00288202 | 0.0284555 | 1 |
Entamoeba histolytica | hypothetical protein | 0.00288202 | 0.0284555 | 0.5 |
Schistosoma mansoni | multidrug resistance protein | 0.00288202 | 0.0284555 | 0.5 |
Loa Loa (eye worm) | ABC transporter transmembrane region family protein | 0.00288202 | 0.0284555 | 0.0280771 |
Schistosoma mansoni | multidrug resistance protein | 0.00288202 | 0.0284555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191705 | 1 | 1 |
Trypanosoma brucei | multidrug resistance protein E | 0.00288202 | 0.0284555 | 0.5 |
Echinococcus granulosus | multidrug resistance associated protein 1 | 0.00288202 | 0.0284555 | 1 |
Leishmania major | p-glycoprotein e | 0.00288202 | 0.0284555 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0191705 | 1 | 1 |
Schistosoma mansoni | multidrug resistance protein | 0.00288202 | 0.0284555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00287549 | 0.0280662 | 0.0276876 |
Trypanosoma cruzi | multidrug resistance protein E, putative | 0.00288202 | 0.0284555 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 6, putative | 0.00288202 | 0.0284555 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 7 | 0.00288202 | 0.0284555 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0191705 | 1 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Echinococcus multilocularis | multidrug resistance associated protein 1 | 0.00288202 | 0.0284555 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0191705 | 1 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.00288202 | 0.0284555 | 1 |
Entamoeba histolytica | multidrug resistance protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Giardia lamblia | ABC transporter, putative | 0.00288202 | 0.0284555 | 1 |
Giardia lamblia | Multidrug resistance-associated protein 1 | 0.00288202 | 0.0284555 | 1 |
Leishmania major | ATP-binding cassette protein subfamily C, member 1, putative | 0.00288202 | 0.0284555 | 0.5 |
Brugia malayi | ABC transporter transmembrane region family protein | 0.00288202 | 0.0284555 | 0.5 |
Leishmania major | pentamidine resistance protein 1 | 0.00288202 | 0.0284555 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Entamoeba histolytica | ABC transporter, putative | 0.00288202 | 0.0284555 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 5, putative | 0.00288202 | 0.0284555 | 0.5 |
Leishmania major | ATP-binding cassette protein subfamily C, member 2, putative | 0.00288202 | 0.0284555 | 0.5 |
Giardia lamblia | MRP-like ABC transporter | 0.00288202 | 0.0284555 | 1 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.00288202 | 0.0284555 | 1 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Trypanosoma cruzi | multidrug resistance-associated protein, putative | 0.00288202 | 0.0284555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00288202 | 0.0284555 | 0.0280771 |
Brugia malayi | multidrug resistance related protein 1 | 0.00288202 | 0.0284555 | 0.5 |
Trypanosoma brucei | p-glycoprotein | 0.00288202 | 0.0284555 | 0.5 |
Trypanosoma brucei | multidrug resistance-associated protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Leishmania major | ABC-thiol transporter | 0.00288202 | 0.0284555 | 0.5 |
Entamoeba histolytica | ATP-binding cassette protein, putative | 0.00288202 | 0.0284555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00288202 | 0.0284555 | 0.0280771 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
CC50 (functional) | > 7.92 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
CC50 | > 7.92 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
EC50 (functional) | = 0.1371 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.1371 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
EC50 (functional) | = 0.2261 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
EC50 (functional) | = 0.2261 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
IFI promiscuity index | = 0.01869 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 18579783 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.