Detailed information for compound 610991

Basic information

Technical information
  • TDR Targets ID: 610991
  • Name: 4-chloro-3-nitro-N-(2,2,6,6-tetramethylpiperi din-4-yl)benzenesulfonamide
  • MW: 375.871 | Formula: C15H22ClN3O4S
  • H donors: 2 H acceptors: 4 LogP: 2.7 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cc(ccc1Cl)S(=O)(=O)NC1CC(C)(C)NC(C1)(C)C
  • InChi: 1S/C15H22ClN3O4S/c1-14(2)8-10(9-15(3,4)18-14)17-24(22,23)11-5-6-12(16)13(7-11)19(20)21/h5-7,10,17-18H,8-9H2,1-4H3
  • InChiKey: NIEKKAFDUVQADE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-chloro-3-nitro-N-(2,2,6,6-tetramethyl-4-piperidyl)benzenesulfonamide
  • 4-chloro-3-nitro-N-(2,2,6,6-tetramethyl-4-piperidinyl)benzenesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0179 0.0179
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4693 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1193 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.1193 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.3065 0.5139
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.1193 0.5
Echinococcus granulosus lamin 0.0026 0.1344 0.2793
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.1193 0.5
Brugia malayi RNA binding protein 0.0062 0.4693 0.4596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.3065 0.5139
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 1 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.4693 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.3065 0.6497
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.4693 0.4693
Echinococcus multilocularis musashi 0.0026 0.1344 0.2793
Echinococcus multilocularis lamin 0.0026 0.1344 0.2793
Onchocerca volvulus 0.0026 0.1344 0.5
Brugia malayi hypothetical protein 0.0016 0.0357 0.0181
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4693 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1193 0.5
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4693 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.1193 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.1298 0.1298
Loa Loa (eye worm) TAR-binding protein 0.0062 0.4693 0.4693
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4693 1
Echinococcus granulosus intermediate filament protein 0.0026 0.1344 0.2793
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.3065 0.5139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.3065 0.6497
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.1193 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.3065 0.6497
Brugia malayi intermediate filament protein 0.0026 0.1344 0.1186
Leishmania major hypothetical protein, conserved 0.0025 0.1193 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.3065 0.3065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.3065 0.6497
Loa Loa (eye worm) RNA binding protein 0.0062 0.4693 0.4693
Loa Loa (eye worm) hypothetical protein 0.0013 0.0046 0.0046
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.4693 0.4596
Loa Loa (eye worm) intermediate filament protein 0.0026 0.1344 0.1344
Schistosoma mansoni tar DNA-binding protein 0.0062 0.4693 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.3065 0.2938
Loa Loa (eye worm) hypothetical protein 0.0026 0.1344 0.1344
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.1344 0.1186
Echinococcus granulosus lamin dm0 0.0026 0.1344 0.2793
Echinococcus multilocularis lamin dm0 0.0026 0.1344 0.2793
Loa Loa (eye worm) hypothetical protein 0.0025 0.1193 0.1193
Onchocerca volvulus 0.0026 0.1344 0.5
Echinococcus multilocularis tar DNA binding protein 0.0062 0.4693 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.1344 0.1344
Brugia malayi TAR-binding protein 0.0062 0.4693 0.4596
Brugia malayi hypothetical protein 0.0025 0.1193 0.1032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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