Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0173 | 0.5 |
Entamoeba histolytica | anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative | 0.0027 | 0.0173 | 0.5 |
Onchocerca volvulus | Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog | 0.0027 | 0.0173 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0619 | 0.0619 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial | 0.0027 | 0.0173 | 0.5 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0027 | 0.0173 | 0.5 |
Brugia malayi | pyruvate dehydrogenase phosphatase regulatory subunit precursor | 0.0027 | 0.0173 | 0.0138 |
Loa Loa (eye worm) | glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0173 | 0.0173 |
Trypanosoma brucei | FAD dependent oxidoreductase, putative | 0.0027 | 0.0173 | 0.5 |
Onchocerca volvulus | Dimethylglycine dehydrogenase, mitochondrial homolog | 0.0027 | 0.0173 | 0.5 |
Echinococcus multilocularis | glycerol 3 phosphate dehydrogenase | 0.0027 | 0.0173 | 0.0823 |
Echinococcus granulosus | FAD dependent oxidoreductase domain containing protein | 0.0027 | 0.0173 | 0.0823 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0.0173 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0063 | 0.1364 | 1 |
Mycobacterium ulcerans | D-amino acid oxidase Aao | 0.0323 | 1 | 1 |
Leishmania major | glycerol-3-phosphate dehydrogenase-like protein | 0.0027 | 0.0173 | 0.5 |
Brugia malayi | cDNA sequence BC016226 | 0.0027 | 0.0173 | 0.0138 |
Brugia malayi | dimethylglycine dehydrogenase, mitochondrial precursor, putative | 0.0027 | 0.0173 | 0.0138 |
Echinococcus granulosus | glycerol 3 phosphate dehydrogenase | 0.0027 | 0.0173 | 0.0823 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0027 | 0.0173 | 0.5 |
Brugia malayi | RE18450p | 0.0027 | 0.0173 | 0.0138 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0534 | 0.3603 |
Entamoeba histolytica | NAD(FAD)-dependent dehydrogenase, putative | 0.0027 | 0.0173 | 0.5 |
Chlamydia trachomatis | D-amino acid dehydrogenase | 0.0027 | 0.0173 | 0.5 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 20 | 0.0027 | 0.0173 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0063 | 0.1364 | 1 |
Echinococcus multilocularis | FAD dependent oxidoreductase domain containing protein | 0.0027 | 0.0173 | 0.0823 |
Schistosoma mansoni | fad oxidoreductase | 0.0027 | 0.0173 | 0.0173 |
Trypanosoma cruzi | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0027 | 0.0173 | 0.5 |
Plasmodium falciparum | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0.0173 | 0.5 |
Schistosoma mansoni | NAD dehydrogenase | 0.0027 | 0.0173 | 0.0173 |
Toxoplasma gondii | FAD-dependent glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0173 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0067 | 0.0067 |
Schistosoma mansoni | bromodomain containing protein | 0.0067 | 0.1488 | 0.1488 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0702 | 0.0702 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.0534 | 0.3603 |
Brugia malayi | Bromodomain containing protein | 0.0079 | 0.1897 | 1 |
Trypanosoma brucei | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0027 | 0.0173 | 0.5 |
Trypanosoma cruzi | FAD dependent oxidoreductase, putative | 0.0027 | 0.0173 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1748 | 0.1748 |
Trypanosoma cruzi | glycerol-3-phosphate dehydrogenase (FAD-dependent), putative | 0.0027 | 0.0173 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0173 | 0.5 |
Trypanosoma brucei | electron transfer flavoprotein-ubiquinone oxidoreductase, putative | 0.0027 | 0.0173 | 0.5 |
Plasmodium vivax | FAD-dependent glycerol-3-phosphate dehydrogenase, putative | 0.0027 | 0.0173 | 0.5 |
Schistosoma mansoni | glycerol-3-phosphate dehydrogenase | 0.0027 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0173 | 0.0173 |
Onchocerca volvulus | Putative fad oxidoreductase | 0.0027 | 0.0173 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0173 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.0617 | 0.2673 |
Schistosoma mansoni | d-amino acid oxidase | 0.0323 | 1 | 1 |
Mycobacterium tuberculosis | Probable D-amino acid oxidase Aao | 0.0296 | 0.9106 | 1 |
Schistosoma mansoni | fad oxidoreductase | 0.0027 | 0.0173 | 0.0173 |
Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0173 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0768 | 0.0768 |
Schistosoma mansoni | ATP:guanidino kinase (Smc74) | 0.0027 | 0.0173 | 0.0173 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0173 | 0.0173 |
Trypanosoma brucei | L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative | 0.0027 | 0.0173 | 0.5 |
Mycobacterium leprae | PROBABLE D-AMINO ACID OXIDASE AAO | 0.0323 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.