Detailed information for compound 613585

Basic information

Technical information
  • TDR Targets ID: 613585
  • Name: N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dih ydro-4H-thieno[5,4-c]pyridin-2-yl]-2,6-difluo robenzamide
  • MW: 441.517 | Formula: C22H17F2N3OS2
  • H donors: 1 H acceptors: 2 LogP: 5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1CCc2c(C1)sc(c2c1nc2c(s1)cccc2)NC(=O)c1c(F)cccc1F
  • InChi: 1S/C22H17F2N3OS2/c1-27-10-9-12-17(11-27)30-22(26-20(28)19-13(23)5-4-6-14(19)24)18(12)21-25-15-7-2-3-8-16(15)29-21/h2-8H,9-11H2,1H3,(H,26,28)
  • InChiKey: XGYSDJVERWJYGI-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-[3-(1,3-benzothiazol-2-yl)-6-methyl-5,7-dihydro-4H-thieno[5,4-c]pyridin-2-yl]-2,6-difluoro-benzamide
  • Oprea1_512894

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Trichomonas vaginalis glucose transporter, putative 0.0038 0.033 0.1973
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0069 0.0791 0.1036
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0196 0.2687 0.3595
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0121 0.0097
Schistosoma mansoni opsin-like receptor 0.0024 0.0121 0.0123
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.033 0.4056
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.033 0.1973
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0024 0.0121 0.0195
Echinococcus multilocularis PHD finger protein rhinoceros 0.021 0.2894 0.2877
Brugia malayi jmjC domain containing protein 0.0068 0.0779 0.0756
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0024 0.0121 0.0123
Brugia malayi Melatonin receptor type 1A 0.0024 0.0121 0.0097
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0024 0.0121 0.0097
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0324 0.0404
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0173 0.0201
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0173 1
Plasmodium falciparum hexose transporter 0.0122 0.1575 0.2094
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Brugia malayi jmjC domain containing protein 0.0068 0.0779 0.0756
Schistosoma mansoni amine GPCR 0.0024 0.0121 0.0123
Plasmodium falciparum protein kinase 6 0.0516 0.743 1
Brugia malayi ORL1-like opioid receptor 0.0024 0.0121 0.0097
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0068 0.0779 0.1557
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0324 0.0404
Trypanosoma cruzi hexose transporter, putative 0.0038 0.033 0.4056
Onchocerca volvulus 0.0024 0.0121 0.0338
Onchocerca volvulus 0.0024 0.0121 0.0338
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0068 0.0779 0.0756
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0121 0.0097
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0024 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Echinococcus granulosus G protein coupled receptor 139 0.0024 0.0121 0.0097
Schistosoma mansoni hypothetical protein 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Echinococcus multilocularis g-protein coupled receptor 0.0024 0.0121 0.0097
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0324 0.0404
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Plasmodium vivax hypothetical protein, conserved 0.021 0.2894 0.3875
Schistosoma mansoni neuropeptide receptor 0.0024 0.0121 0.0123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0121 0.0097
Schistosoma mansoni jumonji domain containing protein 0.0548 0.7898 1
Schistosoma mansoni hypothetical protein 0.0024 0.0121 0.0123
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0068 0.0779 0.0756
Schistosoma mansoni neuropeptide receptor 0.0024 0.0121 0.0123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0024 0.0039
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0323 0.03
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0024 0.0121 0.0195
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0289 0.0265
Echinococcus granulosus neuropeptide receptor A26 0.0024 0.0121 0.0097
Toxoplasma gondii facilitative glucose transporter GT1 0.0122 0.1575 0.3201
Echinococcus granulosus sex peptide receptor 0.0024 0.0121 0.0097
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0121 0.0123
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis lysine specific demethylase 6a 0.0068 0.0779 0.0756
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0324 0.0404
Schistosoma mansoni hypothetical protein 0.0024 0.0121 0.0123
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0121 0.0097
Brugia malayi G-protein coupled receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Brugia malayi Dopamine receptor protein 1 0.0024 0.0121 0.0097
Onchocerca volvulus 0.0024 0.0121 0.0338
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0024 0.0121 0.0097
Entamoeba histolytica protein kinase, putative 0.0037 0.0323 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0173 0.0149
Brugia malayi follicle stimulating hormone receptor 0.0024 0.0121 0.0097
Toxoplasma gondii PHD-finger domain-containing protein 0.021 0.2894 0.5922
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0121 0.0195
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0121 0.0097
Schistosoma mansoni amine GPCR 0.0024 0.0121 0.0123
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0173 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.033 0.3989
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0312 0.0365
Echinococcus granulosus jumonji domain containing protein 0.0293 0.4117 0.4103
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0121 0.0097
Schistosoma mansoni protein kinase 0.0037 0.0323 0.038
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Brugia malayi PHD-finger family protein 0.021 0.2894 0.2877
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0312 0.1003
Plasmodium vivax CDK-related protein kinase 6, putative 0.0516 0.743 1
Loa Loa (eye worm) hypothetical protein 0.021 0.2894 0.4653
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0121 0.0097
Schistosoma mansoni phd/f-box containing protein 0.0068 0.0779 0.0958
Echinococcus granulosus phd:f box containing protein 0.0068 0.0779 0.0756
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0024 0.0121 0.0123
Onchocerca volvulus 0.0024 0.0121 0.0338
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0173 0.0201
Trypanosoma cruzi hexose transporter, putative 0.0038 0.033 0.4056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Trypanosoma brucei glucose transporter 1E 0.0038 0.033 0.3989
Brugia malayi Dopamine receptor protein 2 0.0024 0.0121 0.0097
Brugia malayi putative neuropeptide receptor 0.0024 0.0121 0.0097
Schistosoma mansoni amine GPCR 0.0024 0.0121 0.0123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0121 0.0123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0121 0.0097
Schistosoma mansoni glucose transport protein 0.0122 0.1575 0.197
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0324 0.0404
Schistosoma mansoni glucose transport protein 0.0122 0.1575 0.197
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0299 0.0275
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.052
Brugia malayi AF-10 protein 0.0069 0.0791 0.0769
Brugia malayi neuropeptide F receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.003 0.021 0.0338
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.033 0.3989
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0024 0.0121 0.0195
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0024 0.0121 0.0097
Brugia malayi PHD-finger family protein 0.0069 0.0791 0.0769
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0121 0.0097
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0324 0.0617
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0173 0.0149
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus fmrfamide receptor 0.0024 0.0121 0.0097
Brugia malayi Serotonin receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0121 0.0097
Loa Loa (eye worm) glutamate receptor 0.0039 0.0354 0.0569
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0068 0.0779 0.9834
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0402 0.051
Leishmania major hypothetical protein, conserved 0.0068 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0779 0.1252
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0312 1
Brugia malayi G protein-coupled receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.0024 0.0121 0.0097
Echinococcus granulosus lysine specific demethylase 6a 0.0068 0.0779 0.0756
Echinococcus granulosus allatostatin A receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Brugia malayi Bromodomain containing protein 0.021 0.2894 0.2877
Echinococcus granulosus hypothetical protein 0.0024 0.0121 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0038 0.033 0.1973
Echinococcus granulosus 7tm_1 domain containing protein 0.0024 0.0121 0.0097
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0324 0.0617
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0312 0.1855
Echinococcus multilocularis phd:f box containing protein 0.0068 0.0779 0.0756
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis neuropeptide receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0121 0.0097
Echinococcus granulosus peregrin 0.021 0.2894 0.2877
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0779 0.1252
Echinococcus granulosus metabotropic glutamate receptor 2 0.0033 0.0259 0.0235
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0121 0.0123
Schistosoma mansoni biogenic amine receptor 0.0024 0.0121 0.0123
Schistosoma mansoni histamine h1 receptor 0.0024 0.0121 0.0123
Loa Loa (eye worm) jmjC domain-containing protein 0.0434 0.622 1
Onchocerca volvulus 0.0024 0.0121 0.0338
Echinococcus granulosus g protein coupled receptor 0.0024 0.0121 0.0097
Echinococcus granulosus g protein coupled receptor 0.0024 0.0121 0.0097
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Brugia malayi Dopamine receptor 0.0024 0.0121 0.0097
Onchocerca volvulus 0.0024 0.0121 0.0338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0024 0.0121 0.0123
Schistosoma mansoni neuropeptide receptor 0.0024 0.0121 0.0123
Onchocerca volvulus 0.0024 0.0121 0.0338
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0324 0.0404
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0124 0.0641
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0173 0.052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0312 0.0502
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis allatostatin A receptor 0.0024 0.0121 0.0097
Schistosoma mansoni jumonji/arid domain-containing protein 0.0255 0.3551 0.4479
Onchocerca volvulus 0.0024 0.0121 0.0338
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Schistosoma mansoni protein phosphatase 2C 0.0068 0.0779 0.0958
Onchocerca volvulus 0.0024 0.0121 0.0338
Schistosoma mansoni neuropeptide receptor 0.0024 0.0121 0.0123
Echinococcus multilocularis jumonji domain containing 1A 0.0068 0.0779 0.0756
Echinococcus multilocularis sex peptide receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0068 0.0779 0.1252
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Brugia malayi GnHR receptor homolog 0.0024 0.0121 0.0097
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0121 0.0097
Brugia malayi F/Y-rich N-terminus family protein 0.0069 0.0791 0.0769
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0113 1
Echinococcus granulosus PHD finger protein rhinoceros 0.021 0.2894 0.2877
Schistosoma mansoni hypothetical protein 0.0069 0.0791 0.0974
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0173 0.0961
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0024 0.0121 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Loa Loa (eye worm) jmjC domain-containing protein 0.0255 0.3551 0.5709
Onchocerca volvulus 0.0024 0.0121 0.0338
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus somatostatin receptor 0.0024 0.0121 0.0097
Onchocerca volvulus 0.0024 0.0121 0.0338
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0173 0.0308
Brugia malayi AKH receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis peregrin 0.021 0.2894 0.2877
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0689 1 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0324 0.0404
Brugia malayi larval opioid receptor 0.0024 0.0121 0.0097
Echinococcus granulosus peptide allatostatin:somatostatin 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0402 0.5003
Trypanosoma cruzi hexose transporter, putative 0.0038 0.033 0.4056
Schistosoma mansoni hypothetical protein 0.0024 0.0121 0.0123
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0024 0.0121 0.0123
Brugia malayi sulfakinin receptor protein 0.0024 0.0121 0.0097
Echinococcus multilocularis jumonji domain containing protein 0.0293 0.4117 0.4103
Schistosoma mansoni amine GPCR 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis G protein coupled receptor 139 0.0024 0.0121 0.0097
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0173 0.0189
Brugia malayi jmjC domain containing protein 0.0068 0.0779 0.0756
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0402 0.492
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0024 0.0121 0.0097
Echinococcus multilocularis JmjC domain containing protein 4 0.0068 0.0779 0.0756
Echinococcus multilocularis neuropeptide FF receptor 2 0.0024 0.0121 0.0097
Echinococcus granulosus orexin receptor type 2 0.0024 0.0121 0.0097
Echinococcus granulosus metabotropic glutamate receptor 5 0.0048 0.0489 0.0465
Schistosoma mansoni jumonji domain containing protein 0.0068 0.0779 0.0958
Echinococcus granulosus neuropeptides capa receptor 0.0024 0.0121 0.0097
Leishmania major glucose transporter, lmgt1 0.0038 0.033 0.4056
Loa Loa (eye worm) PHD-finger family protein 0.021 0.2894 0.4653
Loa Loa (eye worm) hypothetical protein 0.0069 0.0791 0.1272
Echinococcus granulosus alpha 1A adrenergic receptor 0.0024 0.0121 0.0097
Schistosoma mansoni amine GPCR 0.0024 0.0121 0.0123
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0323 0.052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0312 0.0288
Echinococcus multilocularis G-protein coupled receptor, putative 0.0024 0.0121 0.0097
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0024 0.0121 0.0123
Plasmodium falciparum phd finger protein, putative 0.021 0.2894 0.3875
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0024 0.0121 0.0097
Echinococcus multilocularis serotonin receptor 0.0024 0.0121 0.0097
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0068 0.0779 1
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0024 0.0121 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0024 0.0121 0.0097
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0779 0.1252
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0121 0.0123
Onchocerca volvulus Alhambra homolog 0.021 0.2894 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0068 0.0779 0.1252
Loa Loa (eye worm) melatonin receptor type 1A 0.0024 0.0121 0.0195
Brugia malayi Tachykinin-like peptides receptor 99D 0.0024 0.0121 0.0097
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0024 0.0121 0.0097
Leishmania major glucose transporter, lmgt3 0.0038 0.033 0.4056
Schistosoma mansoni hypothetical protein 0.0122 0.1575 0.197
Brugia malayi Cam kinase protein 1 0.0037 0.0323 0.03
Schistosoma mansoni hypothetical protein 0.021 0.2894 0.3645
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) neuropeptide F receptor 0.0024 0.0121 0.0195
Toxoplasma gondii PHD-finger domain-containing protein 0.021 0.2894 0.5922
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0024 0.0121 0.0097
Schistosoma mansoni growth hormone secretagogue receptor 0.0024 0.0121 0.0123
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0312 0.0288
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0024 0.0121 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0121 0.0195
Echinococcus multilocularis dro:myosuppressin receptor 0.0024 0.0121 0.0097
Echinococcus granulosus dro:myosuppressin receptor 0.0024 0.0121 0.0097
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0402 0.5003
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0324 0.0404
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0024 0.0121 0.0097
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Loa Loa (eye worm) hypothetical protein 0.0361 0.5125 0.824
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0048 0.0489 0.0465
Schistosoma mansoni biogenic amine (5HT) receptor 0.0024 0.0121 0.0123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0024 0.0121 0.0123
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0024 0.0039
Echinococcus granulosus neuropeptide s receptor 0.0024 0.0121 0.0097
Echinococcus granulosus neuropeptide receptor 0.0024 0.0121 0.0097
Schistosoma mansoni alpha-1 adrenergic receptor 0.0024 0.0121 0.0123
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0069 0.0791 0.1583
Brugia malayi jmjC domain containing protein 0.0255 0.3551 0.3535
Echinococcus granulosus JmjC domain containing protein 4 0.0068 0.0779 0.0756
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0024 0.0121 0.0195
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Schistosoma mansoni protein kinase 0.0037 0.0323 0.038
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0068 0.0779 0.0958
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0024 0.0121 0.0123
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0024 0.0121 0.0338
Entamoeba histolytica protein kinase, putative 0.0037 0.0323 1
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Schistosoma mansoni metabotropic glutamate receptor 0.0033 0.0259 0.0298
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Schistosoma mansoni phosphatidylserine receptor 0.0068 0.0779 0.0958
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Echinococcus multilocularis lysine specific demethylase 5A 0.0255 0.3551 0.3535
Trypanosoma cruzi hexose transporter 0.0038 0.033 0.4056
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0113 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0024 0.0121 0.0097
Brugia malayi putative neuropeptide receptor NPR1 0.0024 0.0121 0.0097
Echinococcus multilocularis neuropeptide Y receptor 0.0024 0.0121 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0323 0.038
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Brugia malayi G-protein coupled receptor 0.0024 0.0121 0.0097
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0791 0.1036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Plasmodium falciparum JmjC domain-containing protein, putative 0.0068 0.0779 0.1019
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0121 0.0123
Toxoplasma gondii PHD-finger domain-containing protein 0.0069 0.0791 0.1583
Echinococcus granulosus lysine specific demethylase 5A 0.0255 0.3551 0.3535
Schistosoma mansoni metabotropic glutamate receptor 0.0019 0.0055 0.0039
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0402 0.051
Brugia malayi neuropeptide F receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0024 0.0121 0.0097
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0196 0.2687 0.5495
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Echinococcus granulosus serotonin receptor 0.0024 0.0121 0.0097
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis serotonin receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) sugar transporter 0.0017 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0312 0.0502
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Plasmodium falciparum protein kinase 7 0.0344 0.487 0.6542
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.021 0.2894 0.3645
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0069 0.0791 1
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0033 0.0259 0.0235
Onchocerca volvulus Neuropeptide F receptor homolog 0.0024 0.0121 0.0338
Loa Loa (eye worm) sugar transporter 0.0122 0.1575 0.2533
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Schistosoma mansoni opsin-like receptor 0.0024 0.0121 0.0123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus neuropeptide receptor 0.0024 0.0121 0.0097
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Toxoplasma gondii protein kinase, putative 0.0344 0.487 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0689 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0121 0.0097
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0024 0.0121 0.0123
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0122 0.1575 0.1555
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus General substrate transporter 0.0104 0.1322 0.13
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0173 0.1976
Loa Loa (eye worm) hypothetical protein 0.0027 0.0173 0.0279
Schistosoma mansoni neuropeptide F-like receptor 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0324 0.0617
Schistosoma mansoni glucose transport protein 0.0122 0.1575 0.197
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0791 0.0974
Onchocerca volvulus 0.0024 0.0121 0.0338
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0323 0.03
Schistosoma mansoni myosin xvIII 0.0024 0.0121 0.0123
Echinococcus multilocularis orexin receptor type 2 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0048 0.0489 0.0785
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Echinococcus granulosus neuropeptide FF receptor 2 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Onchocerca volvulus 0.0024 0.0121 0.0338
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0173 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Echinococcus granulosus g-protein coupled receptor 0.0024 0.0121 0.0097
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0312 0.9253
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0173 0.3046
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0323 0.1927
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0323 0.052
Onchocerca volvulus 0.0024 0.0121 0.0338
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0434 0.052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Onchocerca volvulus 0.0024 0.0121 0.0338
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0323 0.03
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Schistosoma mansoni jumonji/arid domain-containing protein 0.0255 0.3551 0.4479
Brugia malayi jmjC domain containing protein 0.0068 0.0779 0.0756
Brugia malayi metabotropic glutamate receptor type 2 0.0019 0.0055 0.0031
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0068 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0402 0.0779
Echinococcus granulosus 7TM GPCR rhodopsin 0.0024 0.0121 0.0097
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0402 0.5003
Echinococcus multilocularis neuropeptides capa receptor 0.0024 0.0121 0.0097
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Echinococcus granulosus jumonji domain containing 1A 0.0068 0.0779 0.0756
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0312 0.0288
Brugia malayi hypothetical protein 0.0024 0.0121 0.0097
Brugia malayi RE15519p 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.033 0.3989
Trichomonas vaginalis sugar transporter, putative 0.0038 0.033 0.1973
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0024 0.0121 0.0123
Schistosoma mansoni adenoreceptor 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0121 0.0097
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0402 0.5003
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0024 0.0121 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.033 0.1973
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus granulosus neuropeptide Y receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Echinococcus granulosus g protein coupled receptor 0.0024 0.0121 0.0097
Echinococcus granulosus tachykinin peptides receptor 99D 0.0024 0.0121 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Onchocerca volvulus 0.0024 0.0121 0.0338
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0173 0.0189
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0024 0.0121 0.0097
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0323 0.3896
Echinococcus multilocularis General substrate transporter 0.0104 0.1322 0.13
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Trichomonas vaginalis sugar transporter, putative 0.0038 0.033 0.1973
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0077 0.0692
Echinococcus multilocularis fmrfamide receptor 0.0024 0.0121 0.0097
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0312 0.0288
Loa Loa (eye worm) TYRA-2 protein 0.0024 0.0121 0.0195
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0324 0.0404
Leishmania major protein kinase, putative 0.0037 0.0323 0.3962
Schistosoma mansoni biogenic amine receptor 0.0024 0.0121 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Loa Loa (eye worm) G-protein coupled receptor 0.0024 0.0121 0.0195
Plasmodium vivax JmjC domain containing protein 0.0068 0.0779 0.1019
Schistosoma mansoni protein kinase 0.0037 0.0323 0.038
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0173 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0122 0.1575 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0312 0.0365
Plasmodium vivax hexose transporter 0.0122 0.1575 0.2094
Brugia malayi Metabotropic glutamate receptor precursor. 0.0039 0.0354 0.033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Brugia malayi Sugar transporter family protein 0.0122 0.1575 0.1555
Giardia lamblia PHD finger protein 15 0.021 0.2894 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0024 0.0121 0.0123
Loa Loa (eye worm) hypothetical protein 0.0024 0.0121 0.0195
Onchocerca volvulus 0.0024 0.0121 0.0338
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0024 0.0121 0.0097
Brugia malayi Serotonin receptor 0.0024 0.0121 0.0097
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0024 0.0121 0.0097
Schistosoma mansoni neuropeptide f receptor 76f 0.0024 0.0121 0.0123
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0173 0.1976
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0289 0.0265
Leishmania major glucose transporter, lmgt2 0.0038 0.033 0.4056
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0122 0.1575 0.1555
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0069 0.0791 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0173 0.1943
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0068 0.0779 0.1557
Trypanosoma brucei glucose transporter, putative 0.0038 0.033 0.3989
Echinococcus multilocularis g protein coupled receptor 0.0024 0.0121 0.0097
Trichomonas vaginalis glucose transporter, putative 0.0038 0.033 0.1973
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0024 0.0121 0.0097
Schistosoma mansoni biogenic amine receptor 0.0024 0.0121 0.0123
Schistosoma mansoni opsin-like receptor 0.0024 0.0121 0.0123
Brugia malayi G protein-coupled receptor F59B2.13 0.0024 0.0121 0.0097
Echinococcus multilocularis neuropeptide receptor A26 0.0024 0.0121 0.0097
Trypanosoma brucei glucose transporter 2A 0.0038 0.033 0.3989
Echinococcus multilocularis somatostatin receptor 0.0024 0.0121 0.0097
Plasmodium falciparum mitogen-activated protein kinase 2 0.0196 0.2687 0.3595
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0024 0.0121 0.0097
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.